AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53Arg72Pro polymorphism and susceptibility to hepatoc...AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53Arg72Pro polymorphism and susceptibility to hepatocellular carcinoma (HCC) among Chinese population.METHODS: The p53 Arg72Pro genotypes were determined by PCR-based restriction fragment length polymorphism (RFLP) analysis in 507 HCC cases and 541 controls. Odds ratios (ORs) for HCC and 95% confidence intervals (CIs)from unconditional logistic regression models were used to evaluate relative risks. Potential risk factors were included in the logistic regression models as covariates in the multivariate analyses on genotype and HCC.RESULTS: The frequencies for Pro and Arg alleles were 44.5%, 55.5% in HCC cases, and 40.3% and 59.7% in controls, respectively. The Pro allele was significantly associated with the presence of HCC (P = 0.05) and had a higher risk for HCC (OR = 1.19, 95% CI 1.00-1.41) as compared with the Arg allele. After adjusted for potential risk factors, Arg/Pro heterozygotes had an 1.21-fold increased risk (95% CI 0.82-1.78, P = 0.34) of HCC compared with Arg homozygotes, whereas the risk for Pro homozygotes was 1.79 (95% CI 1.06-3.01, P = 0.03) times higher than that for Arg homozygotes. Pro-allele carriers had a higher relative risk of HCC than the Arg-only carriers (adjusted OR = 1.33, 95% CI 0.92-1.92, P = 0.13), although the difference was not statistically significant.CONCLUSION: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population. The p53 Arg72Pro polymorphism may be used as a stratification marker in screening individuals at a high risk of HCC.展开更多
Chandra observations of the Seyfert-2 galaxies NGC 2110 and NGC 7582 arepresented. With the superb spatial resolution of Chandra we found that in NGC 7582 the soft (≤2keV) and hard (2-10 keV) X-rays are emitted in di...Chandra observations of the Seyfert-2 galaxies NGC 2110 and NGC 7582 arepresented. With the superb spatial resolution of Chandra we found that in NGC 7582 the soft (≤2keV) and hard (2-10 keV) X-rays are emitted in different regions, consistent with the report by Xueet al. By comparing the present X-ray data with the previous infrared data, we determined that thesoft X-ray region is the site of starburst activities. We found no significant temporal variationsduring our observations. We confirm the previous finding that NGC 2110 and NGC 7582 areflat-spectrum sources. We argue that the flat spectra may result from a cold absorbing material suchas envisaged in the 'dual absorbed' model. Strong FeK_α emission feature is detected in 6～7keV.Its equivalent width is so large that it cannot be reproduced by using the Galactic column densityof ～ 10^(22) cm^(-2).展开更多
基金Supported by the National Natural Science Foundation of China,No. 30370645, by the Hundred Leading Scientists Program of the Public Health Sector of Shanghai, No, 98BR007
文摘AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53Arg72Pro polymorphism and susceptibility to hepatocellular carcinoma (HCC) among Chinese population.METHODS: The p53 Arg72Pro genotypes were determined by PCR-based restriction fragment length polymorphism (RFLP) analysis in 507 HCC cases and 541 controls. Odds ratios (ORs) for HCC and 95% confidence intervals (CIs)from unconditional logistic regression models were used to evaluate relative risks. Potential risk factors were included in the logistic regression models as covariates in the multivariate analyses on genotype and HCC.RESULTS: The frequencies for Pro and Arg alleles were 44.5%, 55.5% in HCC cases, and 40.3% and 59.7% in controls, respectively. The Pro allele was significantly associated with the presence of HCC (P = 0.05) and had a higher risk for HCC (OR = 1.19, 95% CI 1.00-1.41) as compared with the Arg allele. After adjusted for potential risk factors, Arg/Pro heterozygotes had an 1.21-fold increased risk (95% CI 0.82-1.78, P = 0.34) of HCC compared with Arg homozygotes, whereas the risk for Pro homozygotes was 1.79 (95% CI 1.06-3.01, P = 0.03) times higher than that for Arg homozygotes. Pro-allele carriers had a higher relative risk of HCC than the Arg-only carriers (adjusted OR = 1.33, 95% CI 0.92-1.92, P = 0.13), although the difference was not statistically significant.CONCLUSION: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population. The p53 Arg72Pro polymorphism may be used as a stratification marker in screening individuals at a high risk of HCC.
基金Supported by the National Natural Science Foundation of China.
文摘Chandra observations of the Seyfert-2 galaxies NGC 2110 and NGC 7582 arepresented. With the superb spatial resolution of Chandra we found that in NGC 7582 the soft (≤2keV) and hard (2-10 keV) X-rays are emitted in different regions, consistent with the report by Xueet al. By comparing the present X-ray data with the previous infrared data, we determined that thesoft X-ray region is the site of starburst activities. We found no significant temporal variationsduring our observations. We confirm the previous finding that NGC 2110 and NGC 7582 areflat-spectrum sources. We argue that the flat spectra may result from a cold absorbing material suchas envisaged in the 'dual absorbed' model. Strong FeK_α emission feature is detected in 6～7keV.Its equivalent width is so large that it cannot be reproduced by using the Galactic column densityof ～ 10^(22) cm^(-2).
