An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound healing,and r...An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound healing,and real-time postoperative surveillance.The simulation of electronic skin(e-skin),which emulates the mechanical properties and functions of natural skin,holds significant potential for broad biomedical applications.Herein,a novel multi-responsive controlled-release e-skin(PADM-MX-Ag-Si@Dox)was developed using natural porcine dermal matrix,MXene nanosheets,silver nanowires(AgNWs),and mesoporous hollow silica microspheres(TSOHSiO_(2)@Dox)for drug-loading.The resulting e-skin exhibited temperature-,pH-,and electric-responsiveness due to the incorporation of TSOHSiO_(2)@Dox microspheres,which allowed for on-demand controlled-release of Dox.The biomimetic structure of porcine acellular dermal matrix(PADM)can significantly accelerate the wound healing process under the synergistic effect of electrical stimulation(ES).PADM-MX-Ag-Si@Dox has demonstrated remarkable antimicrobial and electrophysiological activities,thereby establishing a robust basis for enhancing wound healing and facilitating real-time postoperative tumor surveillance.Extensive in vitro and in vivo investigations have substantiated that the combined utilization of PADM-MX-Ag-Si@Dox and ES results in a proactive amalgamation of melanoma postoperative relapse prevention,wound healing,and real-time postoperative surveillance,thereby establishing a potent therapeutic approach for postoperative cancer adjuvant therapy and paving the way for novel precision medical care.展开更多
基金financial support from the National Natural Science Foundation of China(Nos.22278257 and 21804084)the Key Research and the Development Program of Shaanxi Province(No.2022GY-272)+1 种基金the Scientific Research Plan Projects of the Shaanxi Education Department(No.22JY013)the Young Talent Support Program Project of Shaanxi University of Science and Technology Association(No.20200424).
文摘An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound healing,and real-time postoperative surveillance.The simulation of electronic skin(e-skin),which emulates the mechanical properties and functions of natural skin,holds significant potential for broad biomedical applications.Herein,a novel multi-responsive controlled-release e-skin(PADM-MX-Ag-Si@Dox)was developed using natural porcine dermal matrix,MXene nanosheets,silver nanowires(AgNWs),and mesoporous hollow silica microspheres(TSOHSiO_(2)@Dox)for drug-loading.The resulting e-skin exhibited temperature-,pH-,and electric-responsiveness due to the incorporation of TSOHSiO_(2)@Dox microspheres,which allowed for on-demand controlled-release of Dox.The biomimetic structure of porcine acellular dermal matrix(PADM)can significantly accelerate the wound healing process under the synergistic effect of electrical stimulation(ES).PADM-MX-Ag-Si@Dox has demonstrated remarkable antimicrobial and electrophysiological activities,thereby establishing a robust basis for enhancing wound healing and facilitating real-time postoperative tumor surveillance.Extensive in vitro and in vivo investigations have substantiated that the combined utilization of PADM-MX-Ag-Si@Dox and ES results in a proactive amalgamation of melanoma postoperative relapse prevention,wound healing,and real-time postoperative surveillance,thereby establishing a potent therapeutic approach for postoperative cancer adjuvant therapy and paving the way for novel precision medical care.