Background and Objective The morbidity of lower extremity atherosclerotic disease(LEAD)has increased year by year.Chronic stress attenuates the ability of angiogenesis and deteriorates the prognosis of LEAD.Chronic st...Background and Objective The morbidity of lower extremity atherosclerotic disease(LEAD)has increased year by year.Chronic stress attenuates the ability of angiogenesis and deteriorates the prognosis of LEAD.Chronic stress increases plasma and tissue DPP-4 activities in mice.DPP-4 plays an important role in angiogenesis.Therefore,we hypothesized that chronic stress exerted its cardiovascular effects by increasing DPP-4 activation.We investigated the role of DPP-4/GLP-1 axis in ischemiainduced neovascularization in mice under restraint stress.展开更多
Migraine is one of the most prevalent and disabling neurological disease,but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects.Acupuncture is a promising complementary therap...Migraine is one of the most prevalent and disabling neurological disease,but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects.Acupuncture is a promising complementary therapy,but further clinical evidence is needed.The influence of acupuncture on migraine is not an immediate effect,and its mechanism remains unclear.This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved.A randomized controlled trial was performed among 10 normal controls and 38 migraineurs.The migraineurs were divided into blank control,sham acupuncture,and acupuncture groups.Patients were subjected to two courses of treatment,and each treatment lasted for 5 days,with an interval of 1 day between the two courses.The effectiveness of treatment was evaluated using pain questionnaire.The functional magnetic resonance imaging(fMRI)data were analyzed for investigating brain changes induced by treatments.Blood plasma was collected for metabolomics and proteomics studies.Correlation and mediation analyses were performed to investigate the interaction between clinical,fMRI and omics changes.Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect,affected brain regions,and signaling pathways.The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress,reversal of brain energy imbalance,and regulation of inflammation.The brain regions of migraineurs affected by acupuncture include the lingual gyrus,default mode network,and cerebellum.The effect of acupuncture on patients’metabolites/proteins may precede that of the brain.展开更多
文摘Background and Objective The morbidity of lower extremity atherosclerotic disease(LEAD)has increased year by year.Chronic stress attenuates the ability of angiogenesis and deteriorates the prognosis of LEAD.Chronic stress increases plasma and tissue DPP-4 activities in mice.DPP-4 plays an important role in angiogenesis.Therefore,we hypothesized that chronic stress exerted its cardiovascular effects by increasing DPP-4 activation.We investigated the role of DPP-4/GLP-1 axis in ischemiainduced neovascularization in mice under restraint stress.
基金supported by grants from the Ten Thousand Talents Project of the Ministry of Science and Technology,the Young Qihuang Scholars Project of the National Administration of Traditional Chinese Medicine Program and the Beijing Young Talents Program.
文摘Migraine is one of the most prevalent and disabling neurological disease,but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects.Acupuncture is a promising complementary therapy,but further clinical evidence is needed.The influence of acupuncture on migraine is not an immediate effect,and its mechanism remains unclear.This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved.A randomized controlled trial was performed among 10 normal controls and 38 migraineurs.The migraineurs were divided into blank control,sham acupuncture,and acupuncture groups.Patients were subjected to two courses of treatment,and each treatment lasted for 5 days,with an interval of 1 day between the two courses.The effectiveness of treatment was evaluated using pain questionnaire.The functional magnetic resonance imaging(fMRI)data were analyzed for investigating brain changes induced by treatments.Blood plasma was collected for metabolomics and proteomics studies.Correlation and mediation analyses were performed to investigate the interaction between clinical,fMRI and omics changes.Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect,affected brain regions,and signaling pathways.The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress,reversal of brain energy imbalance,and regulation of inflammation.The brain regions of migraineurs affected by acupuncture include the lingual gyrus,default mode network,and cerebellum.The effect of acupuncture on patients’metabolites/proteins may precede that of the brain.
