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结直肠癌术后辅助卡培他滨为基础化疗方案的临床疗效及相关药物基因组学分析 被引量:6
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作者 刘世举 张慧俭 +4 位作者 王金榜 杨会举 张新春 刘翔 刘佃温 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第17期889-893,共5页
目的:本研究旨在探讨结直肠癌(colorectal cancer,CRC)术后辅助卡培他滨为基础化疗方案的疗效及相关药物基因组学分析。方法:回顾性分析2010年1月至2017年6月河南中医药大学第三附属医院收治术后接受辅助化疗的CRC患者215例。收集外周... 目的:本研究旨在探讨结直肠癌(colorectal cancer,CRC)术后辅助卡培他滨为基础化疗方案的疗效及相关药物基因组学分析。方法:回顾性分析2010年1月至2017年6月河南中医药大学第三附属医院收治术后接受辅助化疗的CRC患者215例。收集外周血提取DNA用来进行胞苷脱氨酶(cytidine deaminase,CDD)多态性位点基因分型。另外,收集85例患者的化疗前外周血单核细胞(peripheral blood mononuclear cell,PBMC)提取RNA对CDD的m RNA表达水平进行测定。结果:215例患者具有良好的疗效。药物基因组学分析方面,发现CDD基因启动子区域的多态性位点-451C>A和疗效相关,该位点GA/AA和GG基因型患者的3年无疾病生存率(disease-free survival,DFS)分别为81.03%和62.42%,差异具有统计学意义(P=0.002)。两种基因型患者的5年总生存率(overall survival,OS)分别为72.41%和53.50%,差异具有统计学意义(P=0.016)。在85例患者外周血单核细胞的mRNA表达分析中发现,携带A等位基因的患者相对于GG型患者,外周血单核细胞中CDD的mRNA表达明显较高,差异具有统计学意义(P<0.001)。结论:卡培他滨为基础的化疗方案具有良好的治疗效果。CDD基因-451C>A位点可能通过影响该基因m RNA的表达使CRC患者从卡培他滨的治疗当中获益。 展开更多
关键词 结直肠癌 胞苷脱氨酶 多态性 疗效
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SWOT Analysis on Breeding R&D of Tropical Crops in China in the Context of Implementing UPOV Convention 1991 Act
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作者 Wenhui PU Dingchao DONG +1 位作者 Qiong LI huijian zhang 《Asian Agricultural Research》 2015年第8期11-15,共5页
This paper firstly reviewed development process of UPOV Conventions and briefly introduced current situation of protection of new tropical crop varieties in China. Using SWOT approach,it analyzed internal strengths,we... This paper firstly reviewed development process of UPOV Conventions and briefly introduced current situation of protection of new tropical crop varieties in China. Using SWOT approach,it analyzed internal strengths,weaknesses,external opportunities and threats of breeding R&D of tropical crops if implementing UPOV Convention 1991 Act in China. Internal strengths include rich resources,strategic significance of tropical crops,solid crop breeding foundation,and broad market prospect. Internal weaknesses include insufficient reserve of germplasm resources,weak R&D and protection of new varieties,low market level of breeding R&D entities,unreasonable structure,low input in breeding R&D,and weak protection awareness. Opportunities include bringing into play strengths of rich tropical plant resources,stimulating enthusiasm for new variety R&D and awareness for variety protection,promoting structural optimization of breeding input entities,raising technology level of breeding R&D,and promoting international cooperation of new variety protection. Threats include more strict restriction of intellectual property right,impact to weak fields of new variety R&D,and difficulty in implementing limitation of farmer privileges. Finally,it came up with four recommendations for breeding R&D of tropical crops in China in the contest of implementing UPOV Convention 1991 Act. 展开更多
关键词 SWOT analysis UPOV CONVENTION 1991 ACT TROPICAL cr
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