Carbon dots(CDs),a type of nanoparticle with excellent optical properties,good biocompatibility,and small size,are finding increasing application across the fields of biology and biomedicine.In recent years,biomass-de...Carbon dots(CDs),a type of nanoparticle with excellent optical properties,good biocompatibility,and small size,are finding increasing application across the fields of biology and biomedicine.In recent years,biomass-derived CDs with pharmacological activity(BP-CDs)derived from herbal medicines(HMs),HMs extracts and other natural products with demonstrated pharmaceutical activity have attracted particular attention.Herein,we review recent advances in the development of BP-CDs,covering the selection of biomass precursors,different methods used for the synthesis of BP-CDs from natural sources,and the purification of BP-CDs.Additionally,we summarize the many remarkable properties of BP-CDs including optical properties,biocompatibility and pharmaceutical efficacy.Moreover,the antibacterial,antiviral,anticancer,biosensing,bioimaging,and other applications of BP-CDs are reviewed.Thereafter,we discuss the advantages and disadvantages of BP-CDs and Western drug-derived CDs,highlighting the excellent performance of BP-CDs.Finally,based on the current state of research on BP-CDs,we suggest several aspects of BP-CDs that urgently need to be addressed and identify directions that should be pursued in the future.This comprehensive review on BP-CDs is expected to guide the precise design,preparation,and future development of BP-CDs,thereby advancing the application of BP-CDs in biomedicine.展开更多
基金supported by the National Natural Science Foundation of China(52122308)。
文摘Carbon dots(CDs),a type of nanoparticle with excellent optical properties,good biocompatibility,and small size,are finding increasing application across the fields of biology and biomedicine.In recent years,biomass-derived CDs with pharmacological activity(BP-CDs)derived from herbal medicines(HMs),HMs extracts and other natural products with demonstrated pharmaceutical activity have attracted particular attention.Herein,we review recent advances in the development of BP-CDs,covering the selection of biomass precursors,different methods used for the synthesis of BP-CDs from natural sources,and the purification of BP-CDs.Additionally,we summarize the many remarkable properties of BP-CDs including optical properties,biocompatibility and pharmaceutical efficacy.Moreover,the antibacterial,antiviral,anticancer,biosensing,bioimaging,and other applications of BP-CDs are reviewed.Thereafter,we discuss the advantages and disadvantages of BP-CDs and Western drug-derived CDs,highlighting the excellent performance of BP-CDs.Finally,based on the current state of research on BP-CDs,we suggest several aspects of BP-CDs that urgently need to be addressed and identify directions that should be pursued in the future.This comprehensive review on BP-CDs is expected to guide the precise design,preparation,and future development of BP-CDs,thereby advancing the application of BP-CDs in biomedicine.
