Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the infection.We present a case study of one patient with nephrotic syndrome and membran...Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the infection.We present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in 2016.In early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of cyclosporine.After one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal region.The diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the drainage.We changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and voriconazole.However,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary resuscitation.During the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal function.The focal infection ultimately resolved during the subsequent three years.Neuro-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.展开更多
Traditional Indian medicine or Ayurveda(阿育吠陀)and Traditional Chinese Medicine remain the most ancient yet living traditions.These are the two great traditional medicines with rich philosophical,experiential,and ex...Traditional Indian medicine or Ayurveda(阿育吠陀)and Traditional Chinese Medicine remain the most ancient yet living traditions.These are the two great traditional medicines with rich philosophical,experiential,and experimental basis.Both the systems have been developed and enriched by thousands of years of practices,observations,and experiences.As India and China are neighbors,some exchange of medical ideas and practices might have occurred between the two nations since ancient times.Therefore,when the two traditional medicines are examined closely,many similarities become apparent in the theories and practices along with individual differences.展开更多
This was a rare case,in which clinical manifestation was a thymus area tumor accompanied by proteinuria,kidney dysfunction and kidney enlargement.Tumor biopsy and bone marrow examination failed to clarify its diagnosi...This was a rare case,in which clinical manifestation was a thymus area tumor accompanied by proteinuria,kidney dysfunction and kidney enlargement.Tumor biopsy and bone marrow examination failed to clarify its diagnosis.Renal biopsy revealed diffuse infiltra- tion by atypical lymphoid cells in renal interstitium.Immunoperoxidase studies demonstrated this case was non-Hodgkin's lymphoma (NHL)of the B cell type through the renal biopsy.展开更多
Conventional homeopathy and traditional Chinese medicine(TCM)are two popular alternative systems of medicine,which are practiced also in many countries outsidethe countries of origin.Homeopathy originated in Germany i...Conventional homeopathy and traditional Chinese medicine(TCM)are two popular alternative systems of medicine,which are practiced also in many countries outsidethe countries of origin.Homeopathy originated in Germany in the 19th century and spread throughout the world in spite of antagonism by theorthodox practitioners.It is a holistic medicine based on the principles of treatment where the remedy and the disease have similar symptoms,applies a single potentized medicine at a time,in minimum dose.TCM,also a holistic medicine originating in ancient China about 3000 years ago,has been developed and practiced through centuries till today as one of the most popular alternative medicines in the world.Both the systems ofmedicine have many differences in theories,principles and practices,but they have some important aspects in common.Both are holistic in approach,treating the whole patient,not the affected organs only;focusing on stimulating the intrinsic life principle to bring order,and on homeostasis and balance in the organism.In therapeutics,they may advantageously be applied as adjuvant to each other,producing synergistic effects.展开更多
基金funded by grants from the National Natural Science Foundation of China(Grant No.81570666)International Society of Nephrology Clinical Research Program(Grant No.18-01-0247)+3 种基金Program of Jiangsu Clinical Research Center(Grant No.BL2014084)Jiangsu Province Key Medical Personnel Project(Grant No.ZDRCA2016002)CKD Anemia Research Foundation from China International Medical Foundation(Grant No.Z-2017-24-2037)Outstanding Young and Middle-aged Talents Support Program of the First Affiliated Hospital of Nanjing Medical University(Jiangsu Province Hospital).
文摘Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the infection.We present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in 2016.In early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of cyclosporine.After one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal region.The diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the drainage.We changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and voriconazole.However,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary resuscitation.During the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal function.The focal infection ultimately resolved during the subsequent three years.Neuro-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.
基金Shanghai Planning of Philosophy and Science:2018ZJX007。
文摘Traditional Indian medicine or Ayurveda(阿育吠陀)and Traditional Chinese Medicine remain the most ancient yet living traditions.These are the two great traditional medicines with rich philosophical,experiential,and experimental basis.Both the systems have been developed and enriched by thousands of years of practices,observations,and experiences.As India and China are neighbors,some exchange of medical ideas and practices might have occurred between the two nations since ancient times.Therefore,when the two traditional medicines are examined closely,many similarities become apparent in the theories and practices along with individual differences.
文摘This was a rare case,in which clinical manifestation was a thymus area tumor accompanied by proteinuria,kidney dysfunction and kidney enlargement.Tumor biopsy and bone marrow examination failed to clarify its diagnosis.Renal biopsy revealed diffuse infiltra- tion by atypical lymphoid cells in renal interstitium.Immunoperoxidase studies demonstrated this case was non-Hodgkin's lymphoma (NHL)of the B cell type through the renal biopsy.
文摘Conventional homeopathy and traditional Chinese medicine(TCM)are two popular alternative systems of medicine,which are practiced also in many countries outsidethe countries of origin.Homeopathy originated in Germany in the 19th century and spread throughout the world in spite of antagonism by theorthodox practitioners.It is a holistic medicine based on the principles of treatment where the remedy and the disease have similar symptoms,applies a single potentized medicine at a time,in minimum dose.TCM,also a holistic medicine originating in ancient China about 3000 years ago,has been developed and practiced through centuries till today as one of the most popular alternative medicines in the world.Both the systems ofmedicine have many differences in theories,principles and practices,but they have some important aspects in common.Both are holistic in approach,treating the whole patient,not the affected organs only;focusing on stimulating the intrinsic life principle to bring order,and on homeostasis and balance in the organism.In therapeutics,they may advantageously be applied as adjuvant to each other,producing synergistic effects.