点阵激光治疗斑秃的研究进展

斑秃是一种皮肤科常见的脱发疾病,可影响成人和儿童。目前的一线治疗方案为局部外用糖皮质激素或者局部注射糖皮质激素,但对部分病人来说疗效不佳并且可能引起皮肤萎缩等不良反应。近期,有研究证明点阵激光联合局部外用药物用于治疗斑秃是有效的。本文概述近些年点阵激光在斑秃治疗中的临床应用、作用机制。

Collaborative Optimization of Berth Allocation and Yard Storage in Container Terminals

Considering the interaction between the berth and the yard,this paper studies the collaborative optimization problem of berth allocation and yard storage from the point of the ships over a certain planning period.This collaborative optimization problem is formulated as the integer programming,which aims at minimizing the total truck travel distance.And decision variables are the berthing positions for visiting ships and the storage positions for export containers.Meanwhile,this paper demonstrates the complexity of the problem in theory.And the hybrid tabu genetic algorithm is designed to solve the problem to obtain the optimal berth allocation position and export container storage position.For this algorithm,the rule is applied to generate the initial feasible solutions,and the crossover and mutation operation are simultaneously applied to optimize the initial solutions.Finally,this paper discusses two different scenes:the same berth scene and the same ship scene.The influence of two different scenes on truck travel distance is analyzed by different numerical examples.Numerical examples’results show that the collaborative optimization of berth allocation and yard storage can effectively shorten the truck travel distance and improve the efficiency of terminal operation,which provides the decision support for terminal operators.

Laser-Driven Light Sources for Nanometrology Applications

Laser-driven light sources(LDLS)have ultrahigh-brightness and broad wavelength range.They are ideal radiation sources for optical metrology tools for advanced process control in semiconductor manufacturing.LDLS sources,with their advantages of 170 nm to 2100 nm wavelength range,have been widely adopted and are being used in volume manufacturing for spectroscopic ellipsometry(SE),spectroscopic scatterometry(SS),and white light interferometry(WLI)applications.Such applications are used to measure critical dimensions(CD),overlay(OVL),and film thickness.

Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs

Sepsis is a life-threatening organ dysfunction caused by the dysregulated response of the host to an infection, and treatments are limited. Recently, a novel selenium source, selenium-enriched Cardamine violifolia(SEC) has attracted much attention due to its anti-inflammatory and antioxidant properties, but little is known about its role in the treatment of sepsis. Here, we found that SEC alleviated LPS-induced intestinal damage, as indicated by improved intestinal morphology, and increased disaccharidase activity and tight junction protein expression. Moreover, SEC ameliorated the LPS-induced release of pro-inflammatory cytokines, as indicated by decreased IL-6 level in the plasma and jejunum. Moreover, SEC improved intestinal antioxidant functions by regulating oxidative stress indicators and selenoproteins. In vitro, TNF-α-challenged IPEC-1 cells were examined and showed that selenium-enriched peptides, which are the main functional components extracted from Cardamine violifolia(CSP), increased cell viability, decreased lactate dehydrogenase activity and improved cell barrier function. Mechanistically, SEC ameliorated LPS/TNF-α-induced perturbations in mitochondrial dynamics in the jejunum and IPEC-1 cells. Moreover, CSPmediated cell barrier function is primarily dependent on the mitochondrial fusion protein MFN2 but not MFN1. Taken together,these results indicate that SEC mitigates sepsis-induced intestinal injury, which is associated with modulating mitochondrial fusion.

Simultaneously enhancing the electronic and ionic conductivities of Li_(2)ZnTi_(3)O_(8)via modification with polyacrylonitrile-derived carbon for high-performance anodes

Polyacrylonitrile(PAN)with C≡N bonds can be converted to nitrogen-doped carbon during carbonization,which enhances electronic conductivity by compensating for the deficiency of the Li_(2)ZnTi_(3)O_(8)(LZTO)anode.In this study,LZTO was modified by carbonizing a homogeneous PAN/LZTO powder mixture at approximately 800℃for 5 h in nitrogen stream to uniformly coat nitrogen-doped carbon around the LZTO particles and to yield nitrogen-doped LZTO.PAN-60 exhibited a capacity retention of 74.8%as the current density increased from 0.1 to 1.6 A g−1,and had charge/discharge capacities of 250.1/250.8 mAh g−1 even after 1100 cycles at 0.5 A g−1.Structural and compositional analysis along with electrochemical tests showed that the uniform nitrogen-doped carbon coating and the nitrogen-doped LZTO favor electron transfer,while the defects induced by nitrogen-doping in LZTO promote Li-ion migration.The enhanced electronic and ionic conductivities are favorable to alleviate the polarization during cycling,and thus are responsible for the optimized performance.

Xylooligosaccharide attenuates lipopolysaccharide-induced intestinal injury in piglets via suppressing inflammation and modulating cecal microbial communities

Xylooligosaccharide(XOS)has been considered to be an effective prebiotic,but its exact mechanisms remain unknown.This research was conducted to evaluate the effects of XOS on pig intestinal bacterial community and mucosal barrier using a lipopolysaccharide(LPS)-caused gut damage model.Twenty-four weaned pigs were assigned to 4 treatments in a 2×2 factorial design involving diet(with or without XOS)and immunological challenge(saline or LPS).After 21 d of feeding 0%or 0.02%commercial XOS product,piglets were treated with saline or LPS.After that,blood,small intestinal mucosa and cecal digesta were obtained.Dietary XOS enhanced intestinal mucosal integrity demonstrated by higher villus height,villus height-to-crypt depth ratio,disaccharidase activities and claudin-1 protein expression and lower crypt depth.XOS also caused down-regulation of the gene expression of toll-like receptor 4 and nucleotide-binding oligomerization domain protein signaling,accompanied with decreased pro-inflammatory cytokines and cyclooxygenase 2 contents or mRNA expression and increased heat shock protein 70 mRNA and protein expression.Additionally,increased Bacteroidetes and decreased Firmicutes relative abundance were observed in the piglets fed with XOS.At the genus level,XOS enriched the relative abundance of beneficial bacteria,e.g.,Faecalibacterium,Lactobacillus,and Prevotella.Moreover,XOS enhanced short chain fatty acids contents and inhibited histone deacetylases.The correlation analysis of the combined datasets implied some potential connections between the intestinal microbiota and pro-inflammatory cytokines or cecal metabolites.These results suggest that XOS inhibits inflam-matory response and beneficially modifies microbes and metabolites of the hindgut to protect the in-testine from inflammation-related injury.

Distributive proper forcing axiom and a left-right dichotomy of Cichon's diagram

In this paper, we study distributive proper forcing axiom(DPFA) and prove its consistency with a dichotomy of the Cichon's diagram, relative to certain large cardinal assumption. Namely, we evaluate the cardinal invariants in Cichon's diagram with the first two uncountable cardinals in the way that the left-hand side has the least possible cardinality while the right-hand side has the largest possible value, and preserve the evaluation along the way of forcing DPFA.