Reactive oxygen species(RoS)are essential for biological processes like cell signaling and chemical processes like organic oxidation.Moreover,the sufficient generation of RoS plays a significant role in targeted tumor...Reactive oxygen species(RoS)are essential for biological processes like cell signaling and chemical processes like organic oxidation.Moreover,the sufficient generation of RoS plays a significant role in targeted tumor treatments or oxidation of organics.Herein,a hydrazone-linked porphyrin covalent organic framework(Por-DETH-COF)is developed for red light-induced generation of ROS like singlet oxygen(^(1)O_(2))or superoxide(O_(2)·^(-))to undertake different but targeted oxidations.First,^(1)O_(2)is adopted in photodynamic therapy(PDT)for the oxidation of glioma cells.The PDT efficiency of Por-DETH-COF on the apoptosis of glioma cells is explored through flow cytometry and western blot assay.The apoptosis rate of glioma cells significantly increases over Por-DETH-COF under 660nm red light illumination,suggestive of the potency of^(1)O_(2).Second,O_(2)^(·-)is employed for the targeted oxidation of thiols.A series of thiols could be efficiently oxidized to corresponding disulfides over Por-DETH-COF under 660 nm red light illumination,indicative of the significance of O_(2)^(·-).This work highlights the potential of covalent organic frameworks in generating Ros for precise medical applications of complex chemical environments.展开更多
In order to facilitate high-precision and real-time Precise Point Positioning(PPP),the International GNSS(Global Navigation Satellite System)Service(IGS),BDS-3(BeiDou-3 Navigation Satellite System),and Galileo navigat...In order to facilitate high-precision and real-time Precise Point Positioning(PPP),the International GNSS(Global Navigation Satellite System)Service(IGS),BDS-3(BeiDou-3 Navigation Satellite System),and Galileo navigation satellite system(Galileo)have provided real-time satellite clock correction,which is updated at a high-frequency.However,the frequent updates pose the challenges of increasing the computational burden and compromising the timeliness of these correction parameters.To address this issue,an improved Real-Time Service(RTS)method is developed using an extrapolation algorithm and a linear model.The results indicate that a 1 h arc length of the satellite clock correction series is optimal for fitting a linear model of the RTS.With this approach,the 1 h extrapolation results for BDS-3 and Galileo are superior to 0.09 ns.Moreover,when these model coefficients are transmitted and updated at the intervals of 1,2,5,and 10 min,the corresponding PPP can converge at the centimeter-level.It is evident that these improved RTS methods outperform the current approach with high-frequency interval transmission,as they effectively mitigate the challenges associated with maintaining the timeliness of correction parameters.展开更多
Covalent organic frameworks（COFs） represent an emerging class of porous crystalline materials and have recently shown interesting applications from catalysis to optoelectronic devices.In this review,by covering most...Covalent organic frameworks（COFs） represent an emerging class of porous crystalline materials and have recently shown interesting applications from catalysis to optoelectronic devices.In this review,by covering most of the reported work,we summarized the research progress of two-dimensional（2D）porphyrin- and phthalocyanine-based COFs,with highlighting the synthesis of these 2D COFs via various dynamic covalent reactions and emphasizing their potential applications in different areas.展开更多
基金supported by the National Natural Science Foundation of China(No.22072108).
文摘Reactive oxygen species(RoS)are essential for biological processes like cell signaling and chemical processes like organic oxidation.Moreover,the sufficient generation of RoS plays a significant role in targeted tumor treatments or oxidation of organics.Herein,a hydrazone-linked porphyrin covalent organic framework(Por-DETH-COF)is developed for red light-induced generation of ROS like singlet oxygen(^(1)O_(2))or superoxide(O_(2)·^(-))to undertake different but targeted oxidations.First,^(1)O_(2)is adopted in photodynamic therapy(PDT)for the oxidation of glioma cells.The PDT efficiency of Por-DETH-COF on the apoptosis of glioma cells is explored through flow cytometry and western blot assay.The apoptosis rate of glioma cells significantly increases over Por-DETH-COF under 660nm red light illumination,suggestive of the potency of^(1)O_(2).Second,O_(2)^(·-)is employed for the targeted oxidation of thiols.A series of thiols could be efficiently oxidized to corresponding disulfides over Por-DETH-COF under 660 nm red light illumination,indicative of the significance of O_(2)^(·-).This work highlights the potential of covalent organic frameworks in generating Ros for precise medical applications of complex chemical environments.
基金This research is supported by the National Natural Science Foundation of China(NSFC)(Nos.42174019 and 41974025)the Fundamental Research Funds for the Central Universities.
文摘In order to facilitate high-precision and real-time Precise Point Positioning(PPP),the International GNSS(Global Navigation Satellite System)Service(IGS),BDS-3(BeiDou-3 Navigation Satellite System),and Galileo navigation satellite system(Galileo)have provided real-time satellite clock correction,which is updated at a high-frequency.However,the frequent updates pose the challenges of increasing the computational burden and compromising the timeliness of these correction parameters.To address this issue,an improved Real-Time Service(RTS)method is developed using an extrapolation algorithm and a linear model.The results indicate that a 1 h arc length of the satellite clock correction series is optimal for fitting a linear model of the RTS.With this approach,the 1 h extrapolation results for BDS-3 and Galileo are superior to 0.09 ns.Moreover,when these model coefficients are transmitted and updated at the intervals of 1,2,5,and 10 min,the corresponding PPP can converge at the centimeter-level.It is evident that these improved RTS methods outperform the current approach with high-frequency interval transmission,as they effectively mitigate the challenges associated with maintaining the timeliness of correction parameters.
基金supported by National Natural Science Foundation of China(No.21572170)the Research Fund for the Doctoral Program of Higher Education of China(No.20130141110008)+2 种基金the Outstanding Youth Foundation of Hubei Province(No.2015CFA045)the Beijing National Laboratory for Molecular Sciencesthe Open Foundation of State Key Laboratory of Electronic Thin Films and Integrated Devices(No.KFJJ201505)
文摘Covalent organic frameworks（COFs） represent an emerging class of porous crystalline materials and have recently shown interesting applications from catalysis to optoelectronic devices.In this review,by covering most of the reported work,we summarized the research progress of two-dimensional（2D）porphyrin- and phthalocyanine-based COFs,with highlighting the synthesis of these 2D COFs via various dynamic covalent reactions and emphasizing their potential applications in different areas.
