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Body color plasticity of Diaphorina citri reflects a response to environmental stress
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作者 Jiayao Fan Feng Shang +5 位作者 huimin pan Chenyang Yuan Tianyuan Liu Long Yi Jinjun Wang Wei Dou 《Insect Science》 SCIE CAS CSCD 2024年第3期937-952,共16页
Body color polyphenism is common in Diaphorina citri.Previous studies compared physiological characteristics in D.citri,but the ecological and biological significance of its body color polyphenism remains poorly under... Body color polyphenism is common in Diaphorina citri.Previous studies compared physiological characteristics in D.citri,but the ecological and biological significance of its body color polyphenism remains poorly understood.We studied the ecological and molecular effects of stressors related to body color in D.citri.Crowding or low temperature induced a high proportion of gray morphs,which had smaller bodies,lower body weight,and greater susceptibility to the insecticide dinotefuran.We performed transcriptomic and metabolomics analysis of 2 color morphs in D.citri.Gene expression dynamics revealed that the differentially expressed genes were predominantly involved in energy metabolism,including fatty acid metabolism,amino acid metabolism,and carbohydrate metabolism.Among these genes,plexin,glycosidase,phospholipase,take out,trypsin,and triacylglycerol lipase were differentially expressed in 2 color morphs,and 6 hsps(3 hsp70,hsp83,hsp90,hsp68)were upregulated in gray morphs.The metabolome data showed that blue morphs exhibited a higher abundance of fatty acid and amino acid,whereas the content of carbohydrates was elevated in gray morphs.This study partly explains the body color polyphenism of D.citri and provides insights into the molecular changes of stress response of D.citri. 展开更多
关键词 body color energy metabolism environmental stress phenotypic plasticity POLYPHENISM trade-off
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小鼠CDP-二酰基甘油合成酶-2(Cds2)肝脏特异性敲除导致线粒体功能受损并快速发展为非酒精性肝炎及肝纤维化 被引量:1
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作者 许捷思 陈思宇 +14 位作者 王威 林茜雯 徐扬 张少华 潘慧敏 梁晶晶 黄夏禾 王瑜 李婷 降雨强 汪迎春 丁梅 税光厚 杨洪远 黄勋 《Science Bulletin》 SCIE EI CSCD 2022年第3期299-314,共16页
非酒精性脂肪性肝病(NAFLD)包括单纯脂肪浸润和非酒精性脂肪性肝炎(NASH),继续发展可导致更为严重的肝纤维化、肝硬化和肝癌等.诱导肝脏从单纯脂肪浸润发展成NASH的机制还不是特别清楚.本研究构建了肝脏特异敲除CDP-二酰基甘油合成酶-2(... 非酒精性脂肪性肝病(NAFLD)包括单纯脂肪浸润和非酒精性脂肪性肝炎(NASH),继续发展可导致更为严重的肝纤维化、肝硬化和肝癌等.诱导肝脏从单纯脂肪浸润发展成NASH的机制还不是特别清楚.本研究构建了肝脏特异敲除CDP-二酰基甘油合成酶-2(Cds2)小鼠,并发现该小鼠快速产生肝脏脂肪大量储积、肝炎和肝纤维化等一系列肝脏病变.CDS2定位在线粒体相关内质网膜(MAM)上,敲除Cds2会导致线粒体功能受损和线粒体磷脂酰乙醇胺含量下降.肝脏过表达线粒体磷脂酰乙醇胺合成酶(Pisd)会增加线粒体磷脂酰乙醇胺含量,并减轻肝脏Cds2敲除小鼠肝损伤的表型.另外,过表达Cds2可以抵抗高脂喂食诱导的脂肪肝和肥胖.本研究揭示了小鼠肝脏Cds2生理功能,即Cds2可以调节线粒体磷脂含量和线粒体功能并继而影响NASH的快速发生. 展开更多
关键词 线粒体功能 脂肪浸润 小鼠肝损伤 磷脂酰乙醇胺 二酰基甘油 肝纤维化 肝脏病变 小鼠肝脏
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Data-Driven User Complaint Prediction for Mobile Access Networks 被引量:1
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作者 huimin pan Sheng Zhou +3 位作者 Yunjian Jia Zhisheng Niu Meng Zheng Lu Geng 《Journal of Communications and Information Networks》 2018年第3期9-19,共11页
In this paper,we present a user-complaint prediction system for mobile access networks based on network monitoring data.By applying machine-learning models,the proposed system can relate user complaints to network per... In this paper,we present a user-complaint prediction system for mobile access networks based on network monitoring data.By applying machine-learning models,the proposed system can relate user complaints to network performance indicators,alarm reports in a data-driven fashion,and predict the complaint events in a fine-grained spatial area within a specific time window.The proposed system harnesses several special designs to deal with the specialty in complaint prediction;complaint bursts are extracted using linear filtering and threshold detection to reduce the noisy fluctuation in raw complaint events.A fuzzy gridding method is also proposed to resolve the inaccuracy in verbally described complaint locations.Furthermore,we combine up-sampling with down-sampling to combat the severe skewness towards negative samples.The proposed system is evaluated using a real dataset collected from a major Chinese mobile operator,in which,events due to complaint bursts account approximately for only 0:3%of all recorded events.Re-sults show that our system can detect 30%of complaint bursts 3 h ahead with more than 80%precision.This will achieve a corresponding proportion of quality of experi-ence improvement if all predicted complaint events can be handled in advance through proper network maintenance. 展开更多
关键词 data-driven complaint prediction complaint location network management machine learning pipeline
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