Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Reversal of cancer drug resistance remains a critical challenge in chemotherapy.Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer.To overcome the intrinsic limitations in conventional mitochondrial targeting strategies,we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin(DOX)resistance in lung cancer.Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors.As a consequence,thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice.This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

帕金森病中的关键金属元素

随着我国人口日趋老龄化,老年退行性疾病呈高发态势,据估计当今我国帕金森病患者占世界一半左右。因此,帕金森病日益成为危害我国人民生命健康的突出问题之一。当前临床上对帕金森病无有效治愈手段,而且对于帕金森病的发病机制仍无定论。在诸多可能的诱因中,过渡金属元素的内稳态失衡和氧化应激,被认为与帕金森病相关。本文以生物体两种必需的过渡金属元素铁和铜为中心,介绍了与细胞内铁元素和铜元素代谢相关的信号通路和基因蛋白,并阐述了铁元素或铜元素稳态失衡对神经细胞造成损伤的可能机制。最后,介绍了同步辐射技术应用于帕金森病中元素分析和机制的研究进展,并展望了帕金森病中生物无机问题的未来研究方向。