Doping sites modulation of T-Nb_(2)O_(5) to achieve ultrafast lithium storage

Heteroatoms doping has been regarded as a promising route to modulate the physiochemical properties of electrode materials,in which the doping sites greatly influence the electrochemical performances.However,very few reports focus on enhancing the lithium storage performances of Nb_(2)O_(5) via heteroatoms doping,yet the effect of different doping sites remains unclear.Herein,nitrogen doping has been proposed to improve the fast-charging capability of orthorhombic Nb_(2)O_(5)(T-Nb_(2)O_(5))via a urea-assisted annealing process.Experimental data and theoretical calculation demonstrate that the N doping sites in T-Nb_(2)O_(5) can be tuned by the heating rate,in which substitutional N can increase the spacing of the Li^(+)transport layer as well as reduce the band gap,while interstitial N can provide an electron-rich environment for Li^(+)transport layer and then reduce the Li^(+)diffusion barrier.Arising from the synergistic effect of N doping at different sites,the N-doped T-Nb_(2)O_(5) without carbon coating delivers impressive rate performance(104.6 mA h g^(-1) at 25 C)as well as enhanced cycle stability with a retention of 70.5%over1000 cycles at 5 C.In addition,the assembled lithium ion capacitor exhibits a high energy density of46.6 Wh kg^(-1) even at high power density of 8.4 kW kg^(-1).

Competitive Redox Chemistries in Vanadium Niobium Oxide for Ultrafast and Durable Lithium Storage

Niobium pentoxide(Nb_(2)O_(5))anodes have gained increasing attentions for high-power lithium-ion batteries owing to the outstanding rate capability and high safety.However,Nb2O5 anode suffers poor cycle stability even after modified and the unrevealed mechanisms have restricted the practical applications.Herein,the over-reduction of Nb5+has been demonstrated to be the critical reason for the capacity loss for the first time.Besides,an effective competitive redox strategy has been developed to solve the rapid capacity decay of Nb_(2)O_(5),which can be achieved by the incorporation of vanadium to form a new rutile VNbO_(4)anode.The highly reversible V^(3+)/V^(2+)redox couple in VNbO_(4)can effectively inhibit the over-reduction of Nb^(5+).Besides,the electron migration from V^(3+)to Nb5+can greatly increase the intrinsic electronic conductivity for VNbO4.As a result,VNbO4 anode delivers a high capacity of 206.1 mAh g^(−1)at 0.1 A g^(−1),as well as remarkable cycle performance with a retention of 93.4%after 2000 cycles at 1.0 A g^(−1).In addition,the assembled lithium-ion capacitor demonstrates a high energy density of 44 Wh kg^(−1)at 5.8 kW kg^(−1).In summary,our work provides a new insight into the design of ultra-fast and durable anodes.

可切除胰腺癌的围手术期治疗与全程管理

胰腺癌是恶性程度和致死率极高的消化道恶性肿瘤。可切除胰腺癌是指可以通过手术达到根治性切除的胰腺癌,临床研究表明辅助化疗能延长可切除胰腺癌患者的生存期,但总体预后仍不乐观。目前国内缺乏一套规范的可切除胰腺癌患者全程管理模式。本文通过对可切除胰腺癌近20年来辅助治疗、新辅助治疗、分子靶向治疗、靶向肿瘤微环境的治疗如免疫治疗和肿瘤疫苗、特殊类型可切除胰腺癌的治疗进展进行综述,以期为临床医生对可切除胰腺癌患者的全程管理提供参考。

Exploring the Influences of Continuous Self-Management Education on the Self-Care Skills and Health Behavior of Patients with PICC Intubation

Objective:To analyze the effects of continuous self-management education on the selfcare ability and health behavior of patients with tumor through peripherally inserted central venous catheters(PICC).Methods:The period from August 2018 to August 2020 was used as the research time range,and the random number table method was used as the basis for grouping.80 patients with malignant tumors who regularly performed fixed catheter maintenance care in the PICC clinic of our hospital were admitted in the experimental group(given PICC specialist nursing,and implemented continuous self-management education),and 80 patients with PICC tube malignant tumors discharged from the superior hospital during this time range served as the control group(return to the original catheterization hospital from time to time or perform catheter maintenance care in the nursing clinic of our hospital).The self-care ability scores,health behavior scores,and complications during intubation between both groups were analyzed.Results:(1)There was no significant difference in self-care ability score and healthy behavior score between groups before the intervention,P>0.05;the self-care ability score and health behavior score of the research group were better than the control group after intervention,P<0.05;(2)After investigation,the incidence of complications in the research group(2.50%)was lower than that of the control group(10.00%),but there was no difference between the groups,P>0.05.Conclusion:Continuous self-management education has good effects on improving the self-care ability of tumor patients with PICC intubation.It can urge patients to maintain good health behaviors and reduce complications.It is worthy of promotion.

Green-Emitting Carbon Dots as Fluorescent Probe for Nitrite Detection

Nitrite(NO_(2)_(-))is a well-known inorganic pollutant in food and environment that can trigger severe environmental and healthy problems.Consequently,establishing accurate NO_(2)_(-)detection method is very important for food security,environment monitoring and human health.In this work,green fluorescent carbon dots(CDs)with a high fluorescence quantum yield(QY)of 36.13%are prepared for NO_(2)_(-)detection.The CDs are prepared by one-pot hydrothermal carbonization and polymerization of acriflavine.After carbonization,the anti-photobleaching property of CDs significantly enhanced compared to acriflavine.Under acidic conditions,the added of NO_(2)_(-)selectively induces the aggregation and fluorescence quenching of CDs.A good fluorescence linearity response in the range of 50 nM to 10μM can be developed for NO_(2)_(-)quantitative analysis,with a detection limit of 11.6 nM.Owing to the diazotization reaction of NO_(2)_(-)and the phenylamine groups on the surface of CDs,this method shows excellent selectivity compared to common ions and amino acids.Furthermore,the proposed method shows favorable results in the detection of real water and Cantonese style sausage sample.This study provides a simple and e fficient method for NO_(2)_(-)detection in food and environment.

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

Posterior capsular opacification(PCO),the most common complication after cataract surgery,is caused by the proliferation,migration and differentiation of residual lens epithelial cells(LECs)on the surface of the intraocular lens(IOL).Although drug-loaded IOLs have been successfully developed,the PCO prevention efficacy is still limited due to the lack of targeting and low bioavailability.In this investigation,an exosome-functionalized drug-loaded IOL was successfully developed for effective PCO prevention utilizing the homologous targeting and high biocompatibility of exosome.The exosomes derived from LECs were collected to load the anti-proliferative drug doxorubicin(Dox)through electroporation and then immobilized on the aminated IOLs surface through electrostatic interaction.In vitro experiments showed that significantly improved cellular uptake of Dox@Exos by LECs was achieved due to the targeting ability of exosome,compared with free Dox,thus resulting in superior anti-proliferation effect.In vivo animal investigations indicated that Dox@Exos-IOLs effectively inhibited the development of PCO and showed excellent intraocular biocompatibility.We believe that this work will provide a targeting strategy for PCO prevention through exosome-functionalized IOL.