Objective: To determine the asymptomatic dengue infection in adults of Pakistani population.Methods: This study was conducted in five major cities(Islamabad, Karachi, Lahore,Multan, and Peshawar) of Pakistan.A total o...Objective: To determine the asymptomatic dengue infection in adults of Pakistani population.Methods: This study was conducted in five major cities(Islamabad, Karachi, Lahore,Multan, and Peshawar) of Pakistan.A total of 5 230 adults aged 18 years and above without a history of dengue fever at any point in their life were enrolled from participating laboratories.Those who were confirmed for dengue previously were excluded.Of the total, 62.6%(n = 3 276) were male with an average age of 34.6 years.Participants were briefed about the objectives of the study, and written consent was obtained to perform dengue Ig G test using enzyme linked immunosorbent assay.The brief information related to age, gender and area was also taken on proforma.Results: Overall 32.3%(n = 1 691) was having asymptomatic dengue infection which was 67.5%(n = 756) in Karachi followed by 39.1%(n = 391) in Islamabad, 29.9%(n =316) in Lahore and 21%(n = 228) in Peshawar and none from Multan.More males were affected with asymptomatic dengue infection than females.The asymptomatic dengue infection was significantly higher in different cities; however, there was no significant difference with respect to age groups.Conclusions: The asymptomatic dengue infection is higher in cities i.e.Karachi,Islamabad and Lahore which are at risk of developing secondary dengue infections.There is a need of awareness among the public about secondary dengue infection.展开更多
Curcumin, a polyphenol (diferuloylmethane), is a derivative obtained from the Curcuma longa. It has many beneficial functions, including pain-killing, activity against reactive oxygen species, preventing inflammation ...Curcumin, a polyphenol (diferuloylmethane), is a derivative obtained from the Curcuma longa. It has many beneficial functions, including pain-killing, activity against reactive oxygen species, preventing inflammation and antibacterial activities, for which it has been used for centuries in Ayurvedic medication. The mechanisms showing curcumin activity involve a grouping of signaling pathways in the cell at multiple stages. Recently, the anticancer effects of curcumin were studied on different pathways, including the gene expression for cancer, its spread, the regulation of cell cycle, programmed cell death, and tumor expression. All these studies suggest enormous potential of curcumin in cancer therapy. It has many more potential benefits against cardiovascular diseases, reactive oxygen species, bacteria and fungi. The present review provides a brief description of the studies conducted and the information supportive to pharmaceutical activities of curcumin. It also considers anticancer applications and clinical benefits of nano-formulations of curcumin.展开更多
Reactive oxygen species damage cellular proteins and lipids or form DNA adducts when present in high concentration that promotes carcinogenic activities.Plants have been the primary therapy for such ailments since anc...Reactive oxygen species damage cellular proteins and lipids or form DNA adducts when present in high concentration that promotes carcinogenic activities.Plants have been the primary therapy for such ailments since ancient times.This paper reviews some medicinal plants having antioxidant activities useful for healing cancer,cardiovascular diseases and neuro-protection.A brief overview of the use of medicinal plants and their main constituents effective against reactive oxygen species-based diseases are presented.This overview will attract the interest of investigators aiming at the design of novel therapeutic approaches for the treatment of various reactive oxygen species-based conditions.展开更多
Moringa oleifera,rightly called as the miracle tree,is the extensively grown and highly valuable species of Moringaceae family.The tree has a pantropical distribution with nativity to Indian subcontinent.Nutritionally...Moringa oleifera,rightly called as the miracle tree,is the extensively grown and highly valuable species of Moringaceae family.The tree has a pantropical distribution with nativity to Indian subcontinent.Nutritionally and therapeutically,it is a highly valued plant.Vitamins,proteins,β-carotene,aminoacids and various phenolics such as β-sitosterol,caffeoylquinic acid,kaempferol,quercetin and zeatin with potential for nutritional and therapeutic applications are enriched in different plant parts.Different plant parts of this plant such as roots,leaves,bark,flowers,fruit of immature pods and seeds possess a number of therapeutic properties such as diuretic,antipyretic,antioxidant,anti-inflammatory,antihypertensive,antitumor,antiulcer,antispasmodic,antidiabetic,cholesterol lowering,hepatoprotective and antimicrobial activities,and are being operational in various traditional medicine system for curing different health problems.Moringa is higly beneficial in depression,malnutrition,general weakness and osteoporosis.The present review is intended to emphasize the phytochemical constitution,traditional medicinal uses along pharmacological properties with the purpose to create public awareness regarding therapeutic and nutritive potential of this multipurpose tree as well as to facilitate the pharmacists and the researchers to fill the gap by exploring novel therapeutic compounds that will,of course,be in favor of humanity.展开更多
文摘Objective: To determine the asymptomatic dengue infection in adults of Pakistani population.Methods: This study was conducted in five major cities(Islamabad, Karachi, Lahore,Multan, and Peshawar) of Pakistan.A total of 5 230 adults aged 18 years and above without a history of dengue fever at any point in their life were enrolled from participating laboratories.Those who were confirmed for dengue previously were excluded.Of the total, 62.6%(n = 3 276) were male with an average age of 34.6 years.Participants were briefed about the objectives of the study, and written consent was obtained to perform dengue Ig G test using enzyme linked immunosorbent assay.The brief information related to age, gender and area was also taken on proforma.Results: Overall 32.3%(n = 1 691) was having asymptomatic dengue infection which was 67.5%(n = 756) in Karachi followed by 39.1%(n = 391) in Islamabad, 29.9%(n =316) in Lahore and 21%(n = 228) in Peshawar and none from Multan.More males were affected with asymptomatic dengue infection than females.The asymptomatic dengue infection was significantly higher in different cities; however, there was no significant difference with respect to age groups.Conclusions: The asymptomatic dengue infection is higher in cities i.e.Karachi,Islamabad and Lahore which are at risk of developing secondary dengue infections.There is a need of awareness among the public about secondary dengue infection.
文摘Curcumin, a polyphenol (diferuloylmethane), is a derivative obtained from the Curcuma longa. It has many beneficial functions, including pain-killing, activity against reactive oxygen species, preventing inflammation and antibacterial activities, for which it has been used for centuries in Ayurvedic medication. The mechanisms showing curcumin activity involve a grouping of signaling pathways in the cell at multiple stages. Recently, the anticancer effects of curcumin were studied on different pathways, including the gene expression for cancer, its spread, the regulation of cell cycle, programmed cell death, and tumor expression. All these studies suggest enormous potential of curcumin in cancer therapy. It has many more potential benefits against cardiovascular diseases, reactive oxygen species, bacteria and fungi. The present review provides a brief description of the studies conducted and the information supportive to pharmaceutical activities of curcumin. It also considers anticancer applications and clinical benefits of nano-formulations of curcumin.
文摘Reactive oxygen species damage cellular proteins and lipids or form DNA adducts when present in high concentration that promotes carcinogenic activities.Plants have been the primary therapy for such ailments since ancient times.This paper reviews some medicinal plants having antioxidant activities useful for healing cancer,cardiovascular diseases and neuro-protection.A brief overview of the use of medicinal plants and their main constituents effective against reactive oxygen species-based diseases are presented.This overview will attract the interest of investigators aiming at the design of novel therapeutic approaches for the treatment of various reactive oxygen species-based conditions.
文摘Moringa oleifera,rightly called as the miracle tree,is the extensively grown and highly valuable species of Moringaceae family.The tree has a pantropical distribution with nativity to Indian subcontinent.Nutritionally and therapeutically,it is a highly valued plant.Vitamins,proteins,β-carotene,aminoacids and various phenolics such as β-sitosterol,caffeoylquinic acid,kaempferol,quercetin and zeatin with potential for nutritional and therapeutic applications are enriched in different plant parts.Different plant parts of this plant such as roots,leaves,bark,flowers,fruit of immature pods and seeds possess a number of therapeutic properties such as diuretic,antipyretic,antioxidant,anti-inflammatory,antihypertensive,antitumor,antiulcer,antispasmodic,antidiabetic,cholesterol lowering,hepatoprotective and antimicrobial activities,and are being operational in various traditional medicine system for curing different health problems.Moringa is higly beneficial in depression,malnutrition,general weakness and osteoporosis.The present review is intended to emphasize the phytochemical constitution,traditional medicinal uses along pharmacological properties with the purpose to create public awareness regarding therapeutic and nutritive potential of this multipurpose tree as well as to facilitate the pharmacists and the researchers to fill the gap by exploring novel therapeutic compounds that will,of course,be in favor of humanity.
