Background. The term "clonal nevus" is used to describe a variant of melanocyt ic nevus that histologically exhibits a localized proliferation of pigmented epi thelioid dermal melanocytes within an otherwise...Background. The term "clonal nevus" is used to describe a variant of melanocyt ic nevus that histologically exhibits a localized proliferation of pigmented epi thelioid dermal melanocytes within an otherwise ordinary nevus (Ball NJ, Golitz LE. Melanocytic nevi with focal atypical epithelioid cell components:a review o f seventy-three cases. J Am Acad Dermatol 1994; 30:724-729). Reports to date have focused on the histologic appearance of these lesions. Aim. To characterize the clinical appearance of clonal nevi. Methods. Clinical and histologic examin ations were performed of a single clonal nevus from each of five patients (two m en and three women; age range, 37-80 years). Results. All nevi were round to ov al in shape with smooth, well-defined borders. They were uniformly tan to light brown in color, except for a single blue-gray to blue-black focus of hyperpig mentation. The diameters of the nevi ranged from 2.5 to 10 mm. In individual nev i, the hyperpigmented focus was either centrally or eccentrically located and me asured 1-2 mm in diameter. Histologically, these lesions showed banal melanocyt es associated with a localized proliferation of melanocytes with abundant pigmen ted cytoplasm in the dermis, admixed with melanophages. Conclusions. The appeara nce of clonal nevi-tan with a focus of blue-gray to blue-black pigmentation- allows one to recognize the lesion clinically.展开更多
文摘Background. The term "clonal nevus" is used to describe a variant of melanocyt ic nevus that histologically exhibits a localized proliferation of pigmented epi thelioid dermal melanocytes within an otherwise ordinary nevus (Ball NJ, Golitz LE. Melanocytic nevi with focal atypical epithelioid cell components:a review o f seventy-three cases. J Am Acad Dermatol 1994; 30:724-729). Reports to date have focused on the histologic appearance of these lesions. Aim. To characterize the clinical appearance of clonal nevi. Methods. Clinical and histologic examin ations were performed of a single clonal nevus from each of five patients (two m en and three women; age range, 37-80 years). Results. All nevi were round to ov al in shape with smooth, well-defined borders. They were uniformly tan to light brown in color, except for a single blue-gray to blue-black focus of hyperpig mentation. The diameters of the nevi ranged from 2.5 to 10 mm. In individual nev i, the hyperpigmented focus was either centrally or eccentrically located and me asured 1-2 mm in diameter. Histologically, these lesions showed banal melanocyt es associated with a localized proliferation of melanocytes with abundant pigmen ted cytoplasm in the dermis, admixed with melanophages. Conclusions. The appeara nce of clonal nevi-tan with a focus of blue-gray to blue-black pigmentation- allows one to recognize the lesion clinically.
