Intraocular pressure(IOP)is a key clinical parameter in glaucoma management.However,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lac...Intraocular pressure(IOP)is a key clinical parameter in glaucoma management.However,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a year.Here we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home environment.When excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP.NIR light is minimally absorbed by tissue and is not perceived visually.The sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm Hg.Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits.Implanted sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.展开更多
Photonic crystal(PhC)phosphor,in which the phosphor material is periodically modulated for an enhancement in color-conversion efficiency via resonant absorption of excitation photons,is a paradigm-shifting structural ...Photonic crystal(PhC)phosphor,in which the phosphor material is periodically modulated for an enhancement in color-conversion efficiency via resonant absorption of excitation photons,is a paradigm-shifting structural phosphor platform.Two-dimensional(2D)square-lattice PhC phosphor is currently considered the most advanced platform because of not only its high efficiency,but also its immunity to excitation polarization.In the present study,two major modifications are made to further improve the performance of the 2D PhC phosphor:increasing the refractive index contrast and planarizing the surface.The index contrast is improved by replacing the PhC backbone material with TiO_(2)whereas the surface planarization is achieved by removing excessive colloidal quantum dots from the surface.In comparison with the reference phosphor,the upgraded PhC phosphor exhibits~59 times enhanced absorption(in simulations)and~7 times enhanced emission(in experiments),both of which are unprecedentedly high.Our results not only brighten the viability and applicability of the PhC phosphor but also spur the phosphor development through structural engineering of phosphor materials.展开更多
基金The project was funded by the National Institute of Health(NIH)EY024582the Basic Science Research Program through the National Research Foundation of Korea(NRF)under the Ministry of Education(NRF-2013R1A6A3A03026384).
文摘Intraocular pressure(IOP)is a key clinical parameter in glaucoma management.However,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a year.Here we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home environment.When excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP.NIR light is minimally absorbed by tissue and is not perceived visually.The sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm Hg.Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits.Implanted sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.
基金This work was supported by Samsung Electronics Co,Ltd.(10201209-07856-01)Y.P.acknowledges the support by the Ministry of Science and ICT under the National R&D Program(NRF-2021R1F1A1062182)+1 种基金also by the Ministry of Education under the Basic Science Research Program(NRF-2020R1A6A1A03047771)the both programs were funded through the National Research Foundation of Korea(NRF).
文摘Photonic crystal(PhC)phosphor,in which the phosphor material is periodically modulated for an enhancement in color-conversion efficiency via resonant absorption of excitation photons,is a paradigm-shifting structural phosphor platform.Two-dimensional(2D)square-lattice PhC phosphor is currently considered the most advanced platform because of not only its high efficiency,but also its immunity to excitation polarization.In the present study,two major modifications are made to further improve the performance of the 2D PhC phosphor:increasing the refractive index contrast and planarizing the surface.The index contrast is improved by replacing the PhC backbone material with TiO_(2)whereas the surface planarization is achieved by removing excessive colloidal quantum dots from the surface.In comparison with the reference phosphor,the upgraded PhC phosphor exhibits~59 times enhanced absorption(in simulations)and~7 times enhanced emission(in experiments),both of which are unprecedentedly high.Our results not only brighten the viability and applicability of the PhC phosphor but also spur the phosphor development through structural engineering of phosphor materials.
