Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, anti-aging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, w...Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, anti-aging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory disorders. This work was carried out to investigate the skin whitening effects of Forsythia viridissima-prescription extract (a hydrolyzed extract of Hoechunyangkyeok-san: SID White HYC) on skin. The effects of SID White HYC were assessed the melanin contents in B161 melanoma cells and the pigmented equivalent with HMB45 and Fontana Masson staining in 3D skin model. Then, we examined the expression of major pigment enzymes regulating melanin synthesis and melanosome transport related proteins in B16F1 cells. SID White HYC significantly inhibited the melanin synthesis (56.7% and 30.6% inhibition at 100 μg/mL, intracellular and secreted, respectively) in B16F1 cells and 3D skin model. In addition, western blotting analysis showed that SID White HYC reduced the expression of melanin synthesis and melanosome transport related proteins in B16F1 cells. In clinical trials, the cream containing 0.05% SID White HYC showed skin depigmentation effect without any irritation. These results suggest that SID White HYC may be useful inhibition of melanogenesis and melanosome transport. Therefore, SID White HYC may have potential as a skin-whitening ingredient in cosmetics.展开更多
In a strip winding process,the sleeve is a hollow cylinder that is mounted between a strip coil and a mandrel to maintain uniform coil shape when the strip coil is very thin,but its deformation behavior has not been i...In a strip winding process,the sleeve is a hollow cylinder that is mounted between a strip coil and a mandrel to maintain uniform coil shape when the strip coil is very thin,but its deformation behavior has not been investigated before.Thus,a finite element（FE）model was presented to calculate the stress distribution in a sleeve and strip coil when 1-3mm-thick stainless steel was wound around the sleeve.The FE model was developed by extending aprevious model by adding a sleeve between the mandrel and strip,and by modifying the boundary and interaction conditions.The strip winding process was divided into an initial process and a steady-state process.During the initial process,the minimum and maximum pressure required on the belt wrapper to maintain coil shape by self-friction of the strip was calculated by the FE model when the belt wrapper is ejected at the end of the initial process.After the initial process,an analytical model of the steady-state process was established to calculate the stress distribution and was compared with the FE model to validate it.The suggested analytical model took 11 sto give the same stress distribution that the FE model took 30 dto produce.展开更多
During the thin strip coiling process, it is necessary to use a sleeve with a mandrel to prevent excessive deformation of the strip. Stress distribution in the sleeve and in the strip is an important factor that deter...During the thin strip coiling process, it is necessary to use a sleeve with a mandrel to prevent excessive deformation of the strip. Stress distribution in the sleeve and in the strip is an important factor that determines the quality of the coil. However, owing to the accumulation of high pressure, it is difficult to determine the stress distribution through experimentation. Thus, stress analysis of the strip coiling process was conducted. Finite element analysis was used to investigate the effects of the weight of the strip and the mandrel on the stress distribution and stress concentration near the starting point of the coil. The radial stress was predicted for a coil with a stacked thickness of 384 mm, which corresponds to a strip length of 1486 m, using the stress analysis model developed in a preceding research. A method was presented to reduce the weight and radial stress of a strip coil. It was found that the deformation of the sleeve can be reduced by decreasing the gap between the mandrel segments. The thickness of the sleeve can be reduced from 120 to 106 mm using the stress analysis results. Furthermore, coiling tension can be reduced by 44% compared to the existing value considering the interlayer slip of the strip coil.展开更多
文摘Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, anti-aging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory disorders. This work was carried out to investigate the skin whitening effects of Forsythia viridissima-prescription extract (a hydrolyzed extract of Hoechunyangkyeok-san: SID White HYC) on skin. The effects of SID White HYC were assessed the melanin contents in B161 melanoma cells and the pigmented equivalent with HMB45 and Fontana Masson staining in 3D skin model. Then, we examined the expression of major pigment enzymes regulating melanin synthesis and melanosome transport related proteins in B16F1 cells. SID White HYC significantly inhibited the melanin synthesis (56.7% and 30.6% inhibition at 100 μg/mL, intracellular and secreted, respectively) in B16F1 cells and 3D skin model. In addition, western blotting analysis showed that SID White HYC reduced the expression of melanin synthesis and melanosome transport related proteins in B16F1 cells. In clinical trials, the cream containing 0.05% SID White HYC showed skin depigmentation effect without any irritation. These results suggest that SID White HYC may be useful inhibition of melanogenesis and melanosome transport. Therefore, SID White HYC may have potential as a skin-whitening ingredient in cosmetics.
基金supported by the POSCO Research Project(2015Y011)from POSCO Engineering Solution Centerthe Korea Institute for Advancement of Technology(KIAT)grant funded by the Korea Government Ministry of Trade Industry and Energy(MOTIE).(2015 Establishment of GEM,No.H2001-13-1001)
文摘In a strip winding process,the sleeve is a hollow cylinder that is mounted between a strip coil and a mandrel to maintain uniform coil shape when the strip coil is very thin,but its deformation behavior has not been investigated before.Thus,a finite element（FE）model was presented to calculate the stress distribution in a sleeve and strip coil when 1-3mm-thick stainless steel was wound around the sleeve.The FE model was developed by extending aprevious model by adding a sleeve between the mandrel and strip,and by modifying the boundary and interaction conditions.The strip winding process was divided into an initial process and a steady-state process.During the initial process,the minimum and maximum pressure required on the belt wrapper to maintain coil shape by self-friction of the strip was calculated by the FE model when the belt wrapper is ejected at the end of the initial process.After the initial process,an analytical model of the steady-state process was established to calculate the stress distribution and was compared with the FE model to validate it.The suggested analytical model took 11 sto give the same stress distribution that the FE model took 30 dto produce.
文摘During the thin strip coiling process, it is necessary to use a sleeve with a mandrel to prevent excessive deformation of the strip. Stress distribution in the sleeve and in the strip is an important factor that determines the quality of the coil. However, owing to the accumulation of high pressure, it is difficult to determine the stress distribution through experimentation. Thus, stress analysis of the strip coiling process was conducted. Finite element analysis was used to investigate the effects of the weight of the strip and the mandrel on the stress distribution and stress concentration near the starting point of the coil. The radial stress was predicted for a coil with a stacked thickness of 384 mm, which corresponds to a strip length of 1486 m, using the stress analysis model developed in a preceding research. A method was presented to reduce the weight and radial stress of a strip coil. It was found that the deformation of the sleeve can be reduced by decreasing the gap between the mandrel segments. The thickness of the sleeve can be reduced from 120 to 106 mm using the stress analysis results. Furthermore, coiling tension can be reduced by 44% compared to the existing value considering the interlayer slip of the strip coil.
