Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time,curent applications are mostly limited to research settings.This is due to ...Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time,curent applications are mostly limited to research settings.This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems.However,recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally limited only to the observation of single cells,but can be significantly enhanced to realize deep tissue imaging.To provide insight into how these two closely related fields can expand the limits of bio imaging,we review the recent progresses in their performance and applicable range of studies as well as potential future research directions to push the limits of deep tissuse imnaging.展开更多
基金supported by the National Research Foundation of Korea(Nos.2016R1C1B201530 and 2017M3C7A1044966)the Agency for Defense Development(UD170075FD)the TJ Park Foundation.
文摘Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time,curent applications are mostly limited to research settings.This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems.However,recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally limited only to the observation of single cells,but can be significantly enhanced to realize deep tissue imaging.To provide insight into how these two closely related fields can expand the limits of bio imaging,we review the recent progresses in their performance and applicable range of studies as well as potential future research directions to push the limits of deep tissuse imnaging.
