The concepts of postmortem redistribution(PMR,F)factor,and“theoretical”PMR(Ft)–based upon a drug’s characteristic L/P ratio–have been defined to express the direct relationship between postmortem peripheral blood...The concepts of postmortem redistribution(PMR,F)factor,and“theoretical”PMR(Ft)–based upon a drug’s characteristic L/P ratio–have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration.This paper applies recent data describing liver/peripheral blood(L/P)ratios for many commonly detected drugs to assess these models,and provide a ranking of drugs’propensity for(and degree of)PMR.展开更多
文摘The concepts of postmortem redistribution(PMR,F)factor,and“theoretical”PMR(Ft)–based upon a drug’s characteristic L/P ratio–have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration.This paper applies recent data describing liver/peripheral blood(L/P)ratios for many commonly detected drugs to assess these models,and provide a ranking of drugs’propensity for(and degree of)PMR.
