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慢性丙型肝炎患者的静止期乳糜泻:干扰素治疗对发病和临床预后的影响
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作者 Durante-Mangoni E. iardino p. +2 位作者 Resse M. L.E. Adinolfi 赵丽娜 《世界核心医学期刊文摘(胃肠病学分册)》 2005年第4期54-54,共1页
Goals: To assess the impact of interferon treatment on celiac disease onset in hepatitis C patients and to clarify its clinical relevance and outcome. Background: Hepatitis C is associated with autoimmunity, which can... Goals: To assess the impact of interferon treatment on celiac disease onset in hepatitis C patients and to clarify its clinical relevance and outcome. Background: Hepatitis C is associated with autoimmunity, which can be exacerbated by interferon treatment. Cases of celiac disease activation during interferon treatment have been reported. Study: Retrospective evaluation of 534 hepatitis C patients with or without symptoms compatible with celiac disease onset during interferon treatment and 225 controls. Anti-transglutaminase antibodies were assayed. HLA-DQA1 and -B1 loci were typed. Upper gastrointestinal endoscopy was applied to confirm the diagnosis in antibody positive patients. Results: Anti-transglutaminase antibodies were detected before treatment in 1.3%of hepatitis C patients and in 0.4%of controls (not significant). Eighty-six percent of patients with anti-transglutaminase antibodies showed activation of celiac disease while on interferon. Symptoms ranged from mild to severe, and interferon had to be discontinued in 2 of 7 (29%) patients. Symptoms disappeared in 6 of 7 patients after interferon withdrawal. Onset of symptoms compatible with celiac disease during interferon therapy was significantly associated with the presence of anti-transglutaminase antibodies (OR 53). Conclusions: In hepatitis C patients, the activation of silent celiac disease during interferon treatment is almost universal and should be suspected, but it uncommonly requires interferon treatment discontinuation. Symptoms subside after interferon withdrawal. 展开更多
关键词 丙型肝炎患者 干扰素治疗 乳糜泻 静止期 消化道内镜检查 谷氨酰胺转移酶 白细胞分化抗原 自身免疫 临床相关因素 无症状
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