Adult T-cell leukaemia/lymphoma is alymphopro life rativedis ord eraetiologi call yassociated with human T-cell lymphotropic virus type I infection. A cutan eous lesion often develops in the disease, and in rare cases...Adult T-cell leukaemia/lymphoma is alymphopro life rativedis ord eraetiologi call yassociated with human T-cell lymphotropic virus type I infection. A cutan eous lesion often develops in the disease, and in rare cases, is even the only m anifestation. Here we report a rare case of ‘cutaneous’adult T-cell leukaemia /lymphoma with neither atypical cells in the peripheral blood nor lymph node inv olvement. All nodular lesions were completely eliminated after local electron be am irradiation (20 Gy/nodule in total). To evaluate whether or not there were re sidual lymphoma cells in the skin, we performed PCR to detect clonal T cell rece ptor γgene rearrangements. The sample from the nodule before irradiation showed evidence of a rearranged band, which was not detected at the same site after tr eatment nor in any peripheral blood. The findings suggest that this procedure is useful for the evaluation of therapeutic effects and the early detection of lym phoma recurrence.展开更多
文摘Adult T-cell leukaemia/lymphoma is alymphopro life rativedis ord eraetiologi call yassociated with human T-cell lymphotropic virus type I infection. A cutan eous lesion often develops in the disease, and in rare cases, is even the only m anifestation. Here we report a rare case of ‘cutaneous’adult T-cell leukaemia /lymphoma with neither atypical cells in the peripheral blood nor lymph node inv olvement. All nodular lesions were completely eliminated after local electron be am irradiation (20 Gy/nodule in total). To evaluate whether or not there were re sidual lymphoma cells in the skin, we performed PCR to detect clonal T cell rece ptor γgene rearrangements. The sample from the nodule before irradiation showed evidence of a rearranged band, which was not detected at the same site after tr eatment nor in any peripheral blood. The findings suggest that this procedure is useful for the evaluation of therapeutic effects and the early detection of lym phoma recurrence.
