<strong>Objective: </strong><span style="font-family:""><span style="font-family:Verdana;">This study aimed to evaluate the feasibility, safety, and cosmetic outcomes o...<strong>Objective: </strong><span style="font-family:""><span style="font-family:Verdana;">This study aimed to evaluate the feasibility, safety, and cosmetic outcomes of percutaneous cryoablation (PCA) of breast intraductal carcinoma (IDC) lesions, as well as post-cryoablation magnetic resonance imaging (MRI) as a follow-up tool for detection of residual malignancies and local recurren</span><span><span style="font-family:Verdana;">ces. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Eight female patients underwent percutaneous ultrasound-</span></span><span style="font-family:Verdana;">guided cryoablation of breast IDC tumors under local anesthesia without subsequent resectio</span><span style="font-family:Verdana;">n. All patients received radiation- and endocrine therapies (RT, ET). The patients were followed using vacuum-assisted biopsy (VAB), mammography (MG), magnetic resonance imaging (MRI), and Moiré Topography for cosmetic outcomes. VAB was performed 6 months following cryoablation treatment for cases 1 and 2 (after starting radiation- and endocrine-therapies) or one month after PCA (cases 3, 4, 5, 6 and 7), prior to RT and ET. One patient declined VAB. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Mean age of the patients was 61.9 years, SD 7.7, ages range 53 - 72 years. Mean tumor size was 10.3 mm, SD 2.74, ranged 6.8 - 14.5 mm, median follow-up time was 28 months (range 13 - 34 months). No residual or recurrent malignancies were detected. </span><span style="font-family:Verdana;">One minor adverse event was observed: A skin redness in the ablated area;MRI at one-month post-cryotherapy showed various degrees of thermal burns in all patients in the pectoralis major muscle, which were not symptomatic and were resolved by 6 months following PCA. Decrease of fat necrosis areas in the vicinity of ablated ex-tumor was traced with MRI (mean size 54.9 mm, mean decrease after 2 years was 58%) and validated with VAB. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Per</span><span style="font-family:Verdana;">cutaneous cryoablation of early-stage low-risk breast cancer tumors smaller than 15 mm potentially presents a potential substitute for lumpectomy, o</span><span style="font-family:Verdana;">ffering encouraging short- to mid-term oncology results with good cosmesis outcomes. Patients would be able to benefit from local anesthesia in an outpatient setting and a shorter recovery period.</span></span>展开更多
The demand for gold has increased in the medical and industrial fields. Therefore, recycling this element has become essential. Although gold recovery using microbes has been investigated, there is a dearth of these s...The demand for gold has increased in the medical and industrial fields. Therefore, recycling this element has become essential. Although gold recovery using microbes has been investigated, there is a dearth of these studies on identifying the species that have a high gold recovering ability. Herein, gold (III) removal by microbial cells was investigated to obtain basic information on gold (III) removal from aqueous systems by biosorption and biomineralization. High amounts of gold were removed from the solution containing hydrogen tetrachloroaurate (III) by the tested microbial species, which included bacteria, fungi and yeasts. However, relatively less gold was recovered by biosorption using gram-positive bacteria, fungi, and yeasts than that by gram-negative bacteria. Therefore, we first examined gold (III) removal by biosorption and biomineralization by <i>Pseudomonas saccharophila</i>, which was able to remove the largest amounts of gold (III). Incubation time and other factors affecting gold removal were then examined. <i>P. saccharophila</i> removed about half the amount of gold (III) by biosorption and the remaining half by biomineralization.展开更多
文摘<strong>Objective: </strong><span style="font-family:""><span style="font-family:Verdana;">This study aimed to evaluate the feasibility, safety, and cosmetic outcomes of percutaneous cryoablation (PCA) of breast intraductal carcinoma (IDC) lesions, as well as post-cryoablation magnetic resonance imaging (MRI) as a follow-up tool for detection of residual malignancies and local recurren</span><span><span style="font-family:Verdana;">ces. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Eight female patients underwent percutaneous ultrasound-</span></span><span style="font-family:Verdana;">guided cryoablation of breast IDC tumors under local anesthesia without subsequent resectio</span><span style="font-family:Verdana;">n. All patients received radiation- and endocrine therapies (RT, ET). The patients were followed using vacuum-assisted biopsy (VAB), mammography (MG), magnetic resonance imaging (MRI), and Moiré Topography for cosmetic outcomes. VAB was performed 6 months following cryoablation treatment for cases 1 and 2 (after starting radiation- and endocrine-therapies) or one month after PCA (cases 3, 4, 5, 6 and 7), prior to RT and ET. One patient declined VAB. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Mean age of the patients was 61.9 years, SD 7.7, ages range 53 - 72 years. Mean tumor size was 10.3 mm, SD 2.74, ranged 6.8 - 14.5 mm, median follow-up time was 28 months (range 13 - 34 months). No residual or recurrent malignancies were detected. </span><span style="font-family:Verdana;">One minor adverse event was observed: A skin redness in the ablated area;MRI at one-month post-cryotherapy showed various degrees of thermal burns in all patients in the pectoralis major muscle, which were not symptomatic and were resolved by 6 months following PCA. Decrease of fat necrosis areas in the vicinity of ablated ex-tumor was traced with MRI (mean size 54.9 mm, mean decrease after 2 years was 58%) and validated with VAB. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Per</span><span style="font-family:Verdana;">cutaneous cryoablation of early-stage low-risk breast cancer tumors smaller than 15 mm potentially presents a potential substitute for lumpectomy, o</span><span style="font-family:Verdana;">ffering encouraging short- to mid-term oncology results with good cosmesis outcomes. Patients would be able to benefit from local anesthesia in an outpatient setting and a shorter recovery period.</span></span>
文摘The demand for gold has increased in the medical and industrial fields. Therefore, recycling this element has become essential. Although gold recovery using microbes has been investigated, there is a dearth of these studies on identifying the species that have a high gold recovering ability. Herein, gold (III) removal by microbial cells was investigated to obtain basic information on gold (III) removal from aqueous systems by biosorption and biomineralization. High amounts of gold were removed from the solution containing hydrogen tetrachloroaurate (III) by the tested microbial species, which included bacteria, fungi and yeasts. However, relatively less gold was recovered by biosorption using gram-positive bacteria, fungi, and yeasts than that by gram-negative bacteria. Therefore, we first examined gold (III) removal by biosorption and biomineralization by <i>Pseudomonas saccharophila</i>, which was able to remove the largest amounts of gold (III). Incubation time and other factors affecting gold removal were then examined. <i>P. saccharophila</i> removed about half the amount of gold (III) by biosorption and the remaining half by biomineralization.