Temporal lobe seizures generate a large pool of new hippocampal neurons in the adult brain.Their role within the hyperexcitable neuronal network and how they are regulated by the immune response is unclear.Fractalkine...Temporal lobe seizures generate a large pool of new hippocampal neurons in the adult brain.Their role within the hyperexcitable neuronal network and how they are regulated by the immune response is unclear.Fractalkine and its receptor CX3CR1 constitute a chemokine pathway known to modulate the immune response in temporal lobe epilepsy.Here,6 weeks of intracerebroventricular infusion of anti-CX3CR1 antibody,starting 1 week after electrically induced prolonged seizures in the temporal lobe(status epilepticus(SE)),reduced microglial activation within the hippocampus.展开更多
基金supported by Swedish Research Council,ALF Grant,Zoega’s,Tore Nilson’s Foundation,and EU’s Seventh Framework Programme(FP7/20072013)(602102).
文摘Temporal lobe seizures generate a large pool of new hippocampal neurons in the adult brain.Their role within the hyperexcitable neuronal network and how they are regulated by the immune response is unclear.Fractalkine and its receptor CX3CR1 constitute a chemokine pathway known to modulate the immune response in temporal lobe epilepsy.Here,6 weeks of intracerebroventricular infusion of anti-CX3CR1 antibody,starting 1 week after electrically induced prolonged seizures in the temporal lobe(status epilepticus(SE)),reduced microglial activation within the hippocampus.
