Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury,although cognitive impairments have been reported in these patients.Spinal cord injury result...Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury,although cognitive impairments have been reported in these patients.Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents.Regarding the hippocampus,neurogenesis is reduced and reactive gliosis increased.These longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.展开更多
A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s me...A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.展开更多
文摘Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury,although cognitive impairments have been reported in these patients.Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents.Regarding the hippocampus,neurogenesis is reduced and reactive gliosis increased.These longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
文摘A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.
