Turkey wattle is a by-product generated during slaughter,which has a large amount of connective tissue and is a potential source of glycosaminoglycans(GAGs).This study aimed to extract GAGs from the turkey wattle(Mele...Turkey wattle is a by-product generated during slaughter,which has a large amount of connective tissue and is a potential source of glycosaminoglycans(GAGs).This study aimed to extract GAGs from the turkey wattle(Meleagris gallopavos)and investigate its anticoagulant activity,and its cytotoxic and antiproliferative activity in tumor cells.Chondroitin sulfate(CS-4 and CS-6)and dermatan sulfate(DS)present in the F-VII fraction and hyaluronic acid(HA)in the F-V fraction were identified.The HA showed a high molecular weight(1.0×10^(6) Da)and an apparent cytotoxic/antiproliferative effect against human hepatoma cells.F-VII fraction has an apparent cytotoxic/antiproliferative effect against renal adenoma cells and anticoagulant potential in vitro.The results achieved in this study demonstrated that wattle,a by-product of turkey industrialization,has the potential to be valued as a raw material for the extraction of GAGs with bioactive properties.展开更多
基金The authors would like to thank the Coordination for the Improvement of Higher Education Personnel Brazil(CAPES)for their support in this study.
文摘Turkey wattle is a by-product generated during slaughter,which has a large amount of connective tissue and is a potential source of glycosaminoglycans(GAGs).This study aimed to extract GAGs from the turkey wattle(Meleagris gallopavos)and investigate its anticoagulant activity,and its cytotoxic and antiproliferative activity in tumor cells.Chondroitin sulfate(CS-4 and CS-6)and dermatan sulfate(DS)present in the F-VII fraction and hyaluronic acid(HA)in the F-V fraction were identified.The HA showed a high molecular weight(1.0×10^(6) Da)and an apparent cytotoxic/antiproliferative effect against human hepatoma cells.F-VII fraction has an apparent cytotoxic/antiproliferative effect against renal adenoma cells and anticoagulant potential in vitro.The results achieved in this study demonstrated that wattle,a by-product of turkey industrialization,has the potential to be valued as a raw material for the extraction of GAGs with bioactive properties.
