Dear Editor, The structure of eukaryotic promoter is modular, consisting of different sub-domains （Benfey et al., 1990）. Cross-talk among these sub-domains and effective combinatorial interac- tions between the spe...Dear Editor, The structure of eukaryotic promoter is modular, consisting of different sub-domains （Benfey et al., 1990）. Cross-talk among these sub-domains and effective combinatorial interac- tions between the specific cis-element/s with respective trans- factor/s usually control the strength and tissue specificity of the promoter. Further, specificity/inducibility of promoter can be modified by altering its genetic architecture through ＇cis-rearrangement＇ （Rushton et al., 2002） and ＇swapping of sub-domains＇ （Bhullar et al., 2003）. The fundamental motiva- tion behind developing such modified promoters lies in thebelief that the swapping/shuffling of the upstream activation sequences carrying a specific set of cis-elements that bind to a particular trans-factor from one promoter to the other con- taininq a TATA seauence that miaht result in a novel chimericregu!atory module,展开更多
文摘Dear Editor, The structure of eukaryotic promoter is modular, consisting of different sub-domains （Benfey et al., 1990）. Cross-talk among these sub-domains and effective combinatorial interac- tions between the specific cis-element/s with respective trans- factor/s usually control the strength and tissue specificity of the promoter. Further, specificity/inducibility of promoter can be modified by altering its genetic architecture through ＇cis-rearrangement＇ （Rushton et al., 2002） and ＇swapping of sub-domains＇ （Bhullar et al., 2003）. The fundamental motiva- tion behind developing such modified promoters lies in thebelief that the swapping/shuffling of the upstream activation sequences carrying a specific set of cis-elements that bind to a particular trans-factor from one promoter to the other con- taininq a TATA seauence that miaht result in a novel chimericregu!atory module,
