Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach,however they cannot be absorbed in human body,which may cause a series of complications to influence f...Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach,however they cannot be absorbed in human body,which may cause a series of complications to influence further diagnosis.Magnesium and its alloy have great potential as surgical staples,because they can be degraded in human body and have good mechanical properties and biocompatibility.In this study,Mg-2Zn-0.5Nd(ZN20)alloy fine wires showed great potential as surgical staples.The ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%,respectively,which could be benefit for the deformation of the surgical staples from U-shape to B-shape.The bursting pressure of the wire was about 40 kPa,implying that it can supply sufficient mechanical support after anastomosis.Biochemical test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine wire.The residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the corrosion.The second phase had a negative influence on corrosion property due to galvanic corrosion.The corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire.展开更多
Good mechanical properties and corrosion resistance are the key factors for the application of biodegradable magnesium alloy wires as new medical implant materials.This study is aimed at investigating the influence of...Good mechanical properties and corrosion resistance are the key factors for the application of biodegradable magnesium alloy wires as new medical implant materials.This study is aimed at investigating the influence of micros true tural evolution on mechanical and corrosion properties of Mg-2 Zn-0.5 Nd alloy(ZN20) during room-temperature drawing.The decreases in the crosssectional area of ZN20 alloy during drawing refined the grains from 10 to 5 μm under the influence of cold deformation,the basal texture was rotated around radius direction,the basal texture became dominant,and the texture transformed from drawing direction(DD)//<2111> to a point between <2111> and <2110>parallel to DD.The ultimate tensile strength of the wire was increased by 44.7% compared with that of the extruded alloy due to grain boundary strengthening,hard orientation and work hardening during drawing process,while the elongation was decreased by 85% under the influence of work hardening.The corrosion resistance of the alloy was improved after drawing due to grain refinement,while it was sensitive to prismatic texture.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 52001034, 51871030)Changzhou Sci & Tech Program, China (No. CJ20200078)+2 种基金Natural Science Foundation of Jiangsu Higher Education Institutions of China (No. 20KJB430013)the Top-notch Academic Programs of Jiangsu Higher Education Institutions, China (TAPP)the Priority Academic Program Development of Jiangsu Higher Education Institutions, China (PAPD)
基金the Key Program of China on Biomedical Materials Research and Tissue Organ Replacement(No.2016YFC1101804,2016YFC1100604)National Natural Science Foundation of China(No.51971222,51801220).
文摘Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach,however they cannot be absorbed in human body,which may cause a series of complications to influence further diagnosis.Magnesium and its alloy have great potential as surgical staples,because they can be degraded in human body and have good mechanical properties and biocompatibility.In this study,Mg-2Zn-0.5Nd(ZN20)alloy fine wires showed great potential as surgical staples.The ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%,respectively,which could be benefit for the deformation of the surgical staples from U-shape to B-shape.The bursting pressure of the wire was about 40 kPa,implying that it can supply sufficient mechanical support after anastomosis.Biochemical test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine wire.The residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the corrosion.The second phase had a negative influence on corrosion property due to galvanic corrosion.The corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire.
基金financially supported by the National Key Research and Development Program of China(Nos.2016YFC1101804 and 2016YFC1100604)the National Natural Science Foundation of China(Nos.51971222 and 51801220)the Natural Science Foundation of Liaoning Province of China(No.2019-MS-326)。
文摘Good mechanical properties and corrosion resistance are the key factors for the application of biodegradable magnesium alloy wires as new medical implant materials.This study is aimed at investigating the influence of micros true tural evolution on mechanical and corrosion properties of Mg-2 Zn-0.5 Nd alloy(ZN20) during room-temperature drawing.The decreases in the crosssectional area of ZN20 alloy during drawing refined the grains from 10 to 5 μm under the influence of cold deformation,the basal texture was rotated around radius direction,the basal texture became dominant,and the texture transformed from drawing direction(DD)//<2111> to a point between <2111> and <2110>parallel to DD.The ultimate tensile strength of the wire was increased by 44.7% compared with that of the extruded alloy due to grain boundary strengthening,hard orientation and work hardening during drawing process,while the elongation was decreased by 85% under the influence of work hardening.The corrosion resistance of the alloy was improved after drawing due to grain refinement,while it was sensitive to prismatic texture.
