Porous hydroxyapatite （HA）-tricalcium phosphate （TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates （DCPD） were added at various ra...Porous hydroxyapatite （HA）-tricalcium phosphate （TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates （DCPD） were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity, the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity （- 85%） was observed in the Ca-P scaffold with the lowest HA （-7%） content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content （ - 85%）. X-ray diffraction showed that the extent of the fl-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores, which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and non- etched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.展开更多
基金supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A4A01014136)
文摘Porous hydroxyapatite （HA）-tricalcium phosphate （TCP） ceramic scaffolds were prepared using a screw-type extrusion method with polymer beads. HA and dicalcium phosphate dehydrates （DCPD） were added at various ratios to obtain different HA/TCP ratios in sintered ceramic scaffolds. To further enhance the pore interconnectivity and porosity, the developed porous ceramic scaffolds were etched with acid solutions. The maximum porosity （- 85%） was observed in the Ca-P scaffold with the lowest HA （-7%） content. On the other hand, the maximum compressive strength was noted in the scaffolds with the highest HA content （ - 85%）. X-ray diffraction showed that the extent of the fl-TCP to a-TCP phase transformation increased with decreasing HA/DCPD ratio. All HCl-etched scaffolds were observed to generate micropores, which improved the interconnectivity, while biomineralization was found to be the same for both the HCl-etched and non- etched scaffolds. In particular, hydrochloric acid etching is a promising method for improving the interconnectivity and porosity of the ceramic scaffolds.
