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Fine-tuned mesoporous covalent organic frameworks for highly efficient low molecular-weight proteins separation 被引量:1
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作者 Tienan Wang irfan azhar +7 位作者 Yuting Yang Yao Lu Yuyang Tian Nan Gao Fengchao Cui Li Yang Xiaofei Jing Guangshan Zhu 《Nano Research》 SCIE EI CSCD 2022年第5期4569-4574,共6页
Covalent organic frameworks(COFs)are prominent porous materials for molecules separation due to their desirable structures.However,very few COFs are reported for the separation of macromolecules such as low molecular-... Covalent organic frameworks(COFs)are prominent porous materials for molecules separation due to their desirable structures.However,very few COFs are reported for the separation of macromolecules such as low molecular-weight(MW)proteins.Here,two stable mesoporous COFs(Azo-COF and Tp-COF)with highly crystallized frameworks are synthesized,and their pore sizes are slightly-regulated via elaborate selection of pyrene knots and amino linkages.Benefiting from the pore size difference less than 4 ?,the tandem utilization of these two COFs exhibits efficiently size-selective separation ability towards low MW proteins cytochrome c and myoglobin with small MW difference of 2 kDa,in which protein adsorption possibilities are verified by computational calculations together with confocal laser scanning microscopy(CLSM).Furthermore,a simple COF-based separation device is designed and prepared to achieve effective and low-consumption proteins separation.This work has offered an optimized synthetic strategy for fine-tuned mesoporous COFs and expanded their applications on macromolecules separation. 展开更多
关键词 covalent organic frameworks mesoporous materials pore regulation SEPARATION low molecular-weight protein
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