Brillouin imaging(BI)for micromechanical characterization of tisues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells.Although ...Brillouin imaging(BI)for micromechanical characterization of tisues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells.Although the principles of BI imply its compatibility with in vivo and in situ measurements,the integntion of BI with a flexible catheter,capable of reaching the region of interest within the body,is yet to be reported.Here,for the first time,we experimentally investigate integration of the Brillouin spectroscope with standard optical fber components to achieve a Brillouin endoscope.The performance of single-fiber and dual-fiber endoscopes are demonstrated and analyzed.We show that a major challenge in construction of Bri louin endoscopes is the strong backward Brillouin scattering in the optical fiber and we present a dual-fiber geometry as a possible solution.Measurements of Brillouin spectra in test liquids(water,ethanol and glyoerol)ane demonstrated using the dual-fiber endoscope and its performance is analyzed numerically with the help of a beam propagation model.展开更多
基金support provided through Imperial College Research Fellowship Scheme (G53037).
文摘Brillouin imaging(BI)for micromechanical characterization of tisues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells.Although the principles of BI imply its compatibility with in vivo and in situ measurements,the integntion of BI with a flexible catheter,capable of reaching the region of interest within the body,is yet to be reported.Here,for the first time,we experimentally investigate integration of the Brillouin spectroscope with standard optical fber components to achieve a Brillouin endoscope.The performance of single-fiber and dual-fiber endoscopes are demonstrated and analyzed.We show that a major challenge in construction of Bri louin endoscopes is the strong backward Brillouin scattering in the optical fiber and we present a dual-fiber geometry as a possible solution.Measurements of Brillouin spectra in test liquids(water,ethanol and glyoerol)ane demonstrated using the dual-fiber endoscope and its performance is analyzed numerically with the help of a beam propagation model.
