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外暴露组与呼吸道、皮肤过敏性疾病 被引量:3
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作者 Lorenzo Cecchi Gennaro D Amato +4 位作者 isabella annesi-maesano 高楠楠(翻译) 王俊(翻译) 刘鹏 徐凯峰(审校) 《中华临床免疫和变态反应杂志》 2018年第5期555-564,共10页
变态反应是由多种遗传和环境因素相互作用导致的复杂疾病。然而,过去几十年间变态反应发生率的增加是由同期的环境变化所致。目前,研究者认为变态反应性疾病的发生、发展和恶化都可通过暴露组学加以解释,即从妊娠开始个体所接受的特异... 变态反应是由多种遗传和环境因素相互作用导致的复杂疾病。然而,过去几十年间变态反应发生率的增加是由同期的环境变化所致。目前,研究者认为变态反应性疾病的发生、发展和恶化都可通过暴露组学加以解释,即从妊娠开始个体所接受的特异性和非特异性外部环境的暴露总量(外暴露组)及其对器官和细胞水平的影响(内暴露组)。在研究最深入的外暴露环境因素中,室内和室外空气变应原和空气污染物在变应原的炎性反应发病机制和变态反应性疾病的临床表现中发挥关键作用。气候变化、城市化和生物多样性的丧失会对主要的空气变应原和空气污染物的来源、排放和浓度造成影响,这将是现今和未来数十年变态反应患者的健康和生活质量所面临的最严峻的挑战之一。雷暴相关性哮喘是一个由多种环境因素作用引起的变态反应的生动例子,也可作为了解呼吸道过敏发病机制的体内模型。环境或生活方式引起的肠道和皮肤微生物组异常是变态反应性疾病的关键介质。更好地了解外暴露组对变态反应发展的影响对于敦促患者、卫生专业人员和政策制定者采取行动以减轻环境变化的影响,并适应环境变化具有重要意义。 展开更多
关键词 空气变应原 空气污染 气道高反应 变应原 哮喘 变应性皮炎 生物污染物 气候改变 生物多样性 外暴露组 微生物组 鼻炎 雷暴
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A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach 被引量:3
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作者 Mikhail Sofiev Yuliia Palamarchuk +15 位作者 Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl Christian Bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd isabella annesi-maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes Stephane Zeng Wienczyslawa Czarlewski Jean Bousquet 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第13期1561-1567,共7页
This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers.For decades,information available for the patients and allergologists consisted of pollen counts,whic... This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers.For decades,information available for the patients and allergologists consisted of pollen counts,which are vital but insufficient.New technology paves the way to substantial increase in amount and diversity of the data.This paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk index.This new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and predictions.The new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers. 展开更多
关键词 Pollen allergy Pollen season Google trends Pollen dispersion modeling System for Integrated modeLling of Atmospheric coMposition model Pollen index Air quality index
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Health effects of air pollution:a Southern European perspective 被引量:2
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作者 Giovanni Viegi Sandra Baldacci +6 位作者 Sara Maio Salvatore Fasola isabella annesi-maesano Francesco Pistelli Laura Carrozzi Stefania La Grutta Francesco Forastiere 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第13期1568-1574,共7页
Objective:To summarize the main updated evidence about the health effects of air pollution,with a special focus on Southern Europe.Data sources:Literature was obtained through PubMed Central and the official websites ... Objective:To summarize the main updated evidence about the health effects of air pollution,with a special focus on Southern Europe.Data sources:Literature was obtained through PubMed Central and the official websites of European Agencies and Scientific Societies.Study selection:Recent shreds of evidence about the health effects of air pollution coming from international reports and original research were collected and described in this review.Results:Air pollution is an avoidable risk factor that causes a huge burden for society,in terms of death,health disorders,and huge socio-economic costs.The southern European countries face a more threatening problem because they experience the effects of both anthropogenic pollutants and natural dusts(particulate matter[PM]).The European Environment Agency reported the number of premature deaths in the 28 countries of the European Union attributable to air pollutant exposure in the year 2016:374,000 for PM2.5,68,000 for nitrogen dioxide,and 14,000 for ozone.In Italy,time series and analytical epidemiological studies showed increased cardiorespiratory hospital admissions and mortality,as well as increased risk of respiratory diseases in people living in urban areas.Conclusions:Based on abundant evidence,the World Health Organization,which hosts the Global Alliance against Chronic Respiratory Diseases(GARD),the scientific respiratory societies,and the patients’associations,as well as others in the health sector,must increase their engagement in advocacy for clean air policies. 展开更多
关键词 ENVIRONMENT Respiratory disorders EPIDEMIOLOGY
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