Low carbohydrate diet(LCD)and nutrition is a very popular topic in the nutritional scientific literature.Main reason is that it is an old established therapy in intractable epilepsy and there are plenty of positive pr...Low carbohydrate diet(LCD)and nutrition is a very popular topic in the nutritional scientific literature.Main reason is that it is an old established therapy in intractable epilepsy and there are plenty of positive preclinical and sporadic clinical results in other disorders,including certain cancers.The problem is that a)the metabolic background of this therapy is not elucidated enough,b)animal studies and human experiences are sometimes divergent,c)there are negative human results and d)the clinical studies are not comparable because of the wide variety of study design and conclusion regarding the indication,the composition of diet and duration of treatment can not be drawn.This publication reviews the current situation and gives some hints to the solution.展开更多
文摘Low carbohydrate diet(LCD)and nutrition is a very popular topic in the nutritional scientific literature.Main reason is that it is an old established therapy in intractable epilepsy and there are plenty of positive preclinical and sporadic clinical results in other disorders,including certain cancers.The problem is that a)the metabolic background of this therapy is not elucidated enough,b)animal studies and human experiences are sometimes divergent,c)there are negative human results and d)the clinical studies are not comparable because of the wide variety of study design and conclusion regarding the indication,the composition of diet and duration of treatment can not be drawn.This publication reviews the current situation and gives some hints to the solution.
