In a recent paper published in Nature,York et al.reported that the anti-inflammatory cytokine interleukin(IL)-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation.Deletion of Il10 in mice,or gene...In a recent paper published in Nature,York et al.reported that the anti-inflammatory cytokine interleukin(IL)-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation.Deletion of Il10 in mice,or genetic mutation of IL10 in humans,predisposes to inflammatory bowel disease,which may be overcome by restoring homeostatic sphingolipid metabolism.展开更多
基金Ivan Zanoni is supported by NIH grants(2R01AI121066,2R01DK115217,1R01AI165505,1R01AI170632)the Lloyd J.Old STAR Program(CRI3888)holds an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund.
文摘In a recent paper published in Nature,York et al.reported that the anti-inflammatory cytokine interleukin(IL)-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation.Deletion of Il10 in mice,or genetic mutation of IL10 in humans,predisposes to inflammatory bowel disease,which may be overcome by restoring homeostatic sphingolipid metabolism.
