Acute recurrent pancreatitis is a clinical entity largely associated with pancreatic ductal obstruction. This latter includes congenital variants, of which pancreas divisum is the most frequent but also controversial,...Acute recurrent pancreatitis is a clinical entity largely associated with pancreatic ductal obstruction. This latter includes congenital variants, of which pancreas divisum is the most frequent but also controversial, chronic pancreatitis, tumors of the pancreaticobiliary junction and sphincter of Oddi dysfunction. This review summarizes current knowledge about diagnostic work-up and therapy of these conditions.展开更多
Background:Pancreatic-fluid collections are frequent sequelae of acute and chronic pancreatitis,and endoscopic drainage of these collections has gained acceptance as an alternative to surgical drainage.Methods:Patient...Background:Pancreatic-fluid collections are frequent sequelae of acute and chronic pancreatitis,and endoscopic drainage of these collections has gained acceptance as an alternative to surgical drainage.Methods:Patient data,collection characteristics,drainage technique,and outcomes were obtained through chart review and prospective follow-up for 116 patients with attempted endoscopic drainage of symptomatic pancreatic-fluid collections.Results:A total of 116 patients presented with fluid collections classified as acute fluid collection(n = 5),necrosis(n = 8),acute pseudocyst(n = 30),chronic pseudocyst(n = 64),and pancreatic abscess(n = 9).The median diameter of the collection drained was 60 mm(15-275 mm).Median follow-up after drainage was 21 months.The drainage technique was transpapillary in 15 patients,transmural in 60,and both in 41.Successful resolution of symptoms and collection occurred in 87.9%of cases.No difference in success rates was observed between patients with acute pancreatitis and those with chronic pancreatitis.However,drainage of organized necrosis was associated with a significantly higher failure rate than other collections.No significant differences were observed regarding success when disease,drainage technique,or site of drainage was considered.Complications occurred in 13 patients(11%),and there were 6 deaths in the 30 days after drainage,including one that was procedure related.Conclusions:Endoscopic drainage of pancreatic-fluid collections is successful in the majority of patients and is accompanied by an acceptable complication rate.展开更多
文摘Acute recurrent pancreatitis is a clinical entity largely associated with pancreatic ductal obstruction. This latter includes congenital variants, of which pancreas divisum is the most frequent but also controversial, chronic pancreatitis, tumors of the pancreaticobiliary junction and sphincter of Oddi dysfunction. This review summarizes current knowledge about diagnostic work-up and therapy of these conditions.
文摘Background:Pancreatic-fluid collections are frequent sequelae of acute and chronic pancreatitis,and endoscopic drainage of these collections has gained acceptance as an alternative to surgical drainage.Methods:Patient data,collection characteristics,drainage technique,and outcomes were obtained through chart review and prospective follow-up for 116 patients with attempted endoscopic drainage of symptomatic pancreatic-fluid collections.Results:A total of 116 patients presented with fluid collections classified as acute fluid collection(n = 5),necrosis(n = 8),acute pseudocyst(n = 30),chronic pseudocyst(n = 64),and pancreatic abscess(n = 9).The median diameter of the collection drained was 60 mm(15-275 mm).Median follow-up after drainage was 21 months.The drainage technique was transpapillary in 15 patients,transmural in 60,and both in 41.Successful resolution of symptoms and collection occurred in 87.9%of cases.No difference in success rates was observed between patients with acute pancreatitis and those with chronic pancreatitis.However,drainage of organized necrosis was associated with a significantly higher failure rate than other collections.No significant differences were observed regarding success when disease,drainage technique,or site of drainage was considered.Complications occurred in 13 patients(11%),and there were 6 deaths in the 30 days after drainage,including one that was procedure related.Conclusions:Endoscopic drainage of pancreatic-fluid collections is successful in the majority of patients and is accompanied by an acceptable complication rate.
