The thymus is the primary production site for a functional and self-tolerant T-cell repertoire.The establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TR...The thymus is the primary production site for a functional and self-tolerant T-cell repertoire.The establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T cells.Recent studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].展开更多
基金funded by the Wellcome Trust and the Royal Society(Grant Number 222623/Z/21/Z)KDJ is a Post-Doctoral Fellow supported by an MRC Programme Grant(MR/T029765/1)awarded to Professor Graham Anderson.
文摘The thymus is the primary production site for a functional and self-tolerant T-cell repertoire.The establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T cells.Recent studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].
