I. INTRODUCTIONMetallothioneins(MT) are ubiquitously distributed in animal and plant kingdoms. They are cysteine-rich proteins that specifically bind heavy metal ions, such as cadmium, zinc, mercury and copper. The hi...I. INTRODUCTIONMetallothioneins(MT) are ubiquitously distributed in animal and plant kingdoms. They are cysteine-rich proteins that specifically bind heavy metal ions, such as cadmium, zinc, mercury and copper. The high expression of the MT gene could be induced by heavy metals in vitro and in vivo. The first transgenic mice obtained by Palmiter et al. in 1982 were introduced with an exogenous growth hormnoe gene展开更多
1 Introduction Metallothioneins (MTs) are a family of low-molecular weight heavy metal binding proteins, unique in their high cystein content. MTs are ubiquitously distributed in the eukaryote from yeast to human. It ...1 Introduction Metallothioneins (MTs) are a family of low-molecular weight heavy metal binding proteins, unique in their high cystein content. MTs are ubiquitously distributed in the eukaryote from yeast to human. It is an experimental model emphasized during researching gene expression and regulation of animal cells. In order to provide inducible regulatory elements for transgenosis livestock, we cloned bovine MT genes. At least four members of bovine MT family have been discovered. In this note, one gene (bMTc) of展开更多
基金Project supported in part by a grant-in-aid from Rockefeller Foundation, New York.
文摘I. INTRODUCTIONMetallothioneins(MT) are ubiquitously distributed in animal and plant kingdoms. They are cysteine-rich proteins that specifically bind heavy metal ions, such as cadmium, zinc, mercury and copper. The high expression of the MT gene could be induced by heavy metals in vitro and in vivo. The first transgenic mice obtained by Palmiter et al. in 1982 were introduced with an exogenous growth hormnoe gene
基金Project partially supported by the Rockefeller Foundation.
文摘1 Introduction Metallothioneins (MTs) are a family of low-molecular weight heavy metal binding proteins, unique in their high cystein content. MTs are ubiquitously distributed in the eukaryote from yeast to human. It is an experimental model emphasized during researching gene expression and regulation of animal cells. In order to provide inducible regulatory elements for transgenosis livestock, we cloned bovine MT genes. At least four members of bovine MT family have been discovered. In this note, one gene (bMTc) of
