Drying Kinetics and Energy Consumption in Vacuum Drying Process with Microwave and Radiant Heating

The general objective of this work is to analyze energy input in a vacuum process with the incorporation of microwave heating. Thus, necessary criteria for designing an efficient freeze-drying operation are considered through the analysis of strategies based on the combination of different intensities of radiant and microwave heating.The other aim of this research topic is to study the kinetics of drying in relation to mass transfer parameters.Five freeze-drying strategies using both heating systems were used. Consequently, energy input could be related to diffusivity coefficients, temperature and pressure profiles during dehydration of the product and analyzed in comparison to a conventional freeze-drying process.

用真空度和加热功率的双重控制缩短药液的冷冻干燥时间

在抗菌素及其它药品的生产过程中,一种常用方法是将药瓶中的冻液冷冻干燥,首先用一个球模型描述了冻核逐渐变小的冷冻干燥过程,模拟了对脱水物质能产生最大温度驱动力,而且质量和设备性能都已给定情况下的冷冻干燥工艺,指出双重控制真空度和加热功率是一种可行的冷冻干燥方法。利用这种方法,常规那种在药瓶中进行冷冻干燥所需要的冷冻干燥时间可明显缩短。最后讨论了用该操怍方法出现的一些问题。