Background: Despite having a positive patch test reaction to para-phenylenediamine (PPD), some patients continue to dye their hair, while others are forced to give up or abandon this practice. This difference in patie...Background: Despite having a positive patch test reaction to para-phenylenediamine (PPD), some patients continue to dye their hair, while others are forced to give up or abandon this practice. This difference in patient behaviour could be due to the degree of sensitization. Objectives: To establish whether the ability to continue dyeing hair in PPD allergic patients is related to the strength of patch test reaction. To note differences in other clinical features in relation to the strength of patch test reaction. Methods We analysed retrospectively the patch test records of 400 sequential PPD-positive patients for the strength of patch test reaction (+, ++, +++) and different clinical features. Data were analysed using Cochran-Mantel-Haenszel χ2 tests. Results: There was a strong linear relationship between the strength of patch test reaction and continuation with hair dyeing. Patients were more likely to report a history of hair dye reaction with increasing strength of patch test reaction. There was no difference in strength of patch test reaction in relation to age, site of rash, occupation (hairdressing) or history of atopic eczema. Overall concomitant reactivity with related aromatic amine allergens (benzocaine,N-isopropyl-Nphenyl-para-phenylenediamine, para-aminobenzoic acid) was infrequent. Conclusions: Patients with stronger patch test reactions (++, +++) are more likely to have a clear history of reacting to hair dye and are less likely to still be dyeing their hair.展开更多
A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed i n the EUInventory of Fragrance Ingredients. Positive react...A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed i n the EUInventory of Fragrance Ingredients. Positive reactions were found to iso eugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzo ate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzy l isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl ace tate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl pheny lacetate but in none of those 6 positive to isoeugenyl methyl ether and in neith er of those 2 positive to benzylisoeugenyl ether. Concomitant contact allergy be tween isoeugenol and its derivatives may occur through chemical cross-reactivit y or local skin metabolism of the derivatives. It is more commonly observed with the esters rather than the ethers. Isoeugenyl acetate has been proposed as an a lternative to isoeugenol, but there is a high degree of concomit an treactivity with isoeugenol.展开更多
文摘Background: Despite having a positive patch test reaction to para-phenylenediamine (PPD), some patients continue to dye their hair, while others are forced to give up or abandon this practice. This difference in patient behaviour could be due to the degree of sensitization. Objectives: To establish whether the ability to continue dyeing hair in PPD allergic patients is related to the strength of patch test reaction. To note differences in other clinical features in relation to the strength of patch test reaction. Methods We analysed retrospectively the patch test records of 400 sequential PPD-positive patients for the strength of patch test reaction (+, ++, +++) and different clinical features. Data were analysed using Cochran-Mantel-Haenszel χ2 tests. Results: There was a strong linear relationship between the strength of patch test reaction and continuation with hair dyeing. Patients were more likely to report a history of hair dye reaction with increasing strength of patch test reaction. There was no difference in strength of patch test reaction in relation to age, site of rash, occupation (hairdressing) or history of atopic eczema. Overall concomitant reactivity with related aromatic amine allergens (benzocaine,N-isopropyl-Nphenyl-para-phenylenediamine, para-aminobenzoic acid) was infrequent. Conclusions: Patients with stronger patch test reactions (++, +++) are more likely to have a clear history of reacting to hair dye and are less likely to still be dyeing their hair.
文摘A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed i n the EUInventory of Fragrance Ingredients. Positive reactions were found to iso eugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzo ate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzy l isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl ace tate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl pheny lacetate but in none of those 6 positive to isoeugenyl methyl ether and in neith er of those 2 positive to benzylisoeugenyl ether. Concomitant contact allergy be tween isoeugenol and its derivatives may occur through chemical cross-reactivit y or local skin metabolism of the derivatives. It is more commonly observed with the esters rather than the ethers. Isoeugenyl acetate has been proposed as an a lternative to isoeugenol, but there is a high degree of concomit an treactivity with isoeugenol.
