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Synthesis of P,N-2,2'-biphenyl derivatives with central chirality
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作者 jean ludovic POULIQUEN Michael +2 位作者 BLANCHET Jérme LASNE Marie-Claire ROUDEN Jacques 《Science China Chemistry》 SCIE EI CAS 2010年第9期1907-1913,共7页
Enantiopure 2-(dicyclohexylphosphino)-1,1'-biphenyl derivatives substituted in the 2'-position by a chiral amino group were prepared.For the compound bearing an acyclic chiral chain,the key step was a Suzuki c... Enantiopure 2-(dicyclohexylphosphino)-1,1'-biphenyl derivatives substituted in the 2'-position by a chiral amino group were prepared.For the compound bearing an acyclic chiral chain,the key step was a Suzuki coupling between bromobenzeneboronic acid and N-Boc-iodoaniline whereas an aromatic nucleophilic substitution allowed the introduction of a chiral pyrrolidine in the 2'-position of the biphenyl backbone.The efficiency of the P,N-biphenyl pyrrolidine derivatives as ligands in Pd-catalyzed arylaminations compares well with that of DavePhos ligand. 展开更多
关键词 3-aminopyrrolidines SUZUKI coupling BIPHENYLS CHIRAL LIGAND arylamination
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