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H1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus
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作者 YI-NONG CHEN YING-LIN CHEN +4 位作者 WAN-MING CHEN MINGCHIH CHEN BEN-CHANG SHIA jenq-yuh ko SZU-YUAN WU 《Oncology Research》 SCIE 2023年第1期23-34,共12页
This study aimed to examine the association between the use of H1-antihistamines(AHs)and head and neck cancer(HNC)risk in patients with type 2 diabetes mellitus(T2DM).Data from the National Health Insurance Research D... This study aimed to examine the association between the use of H1-antihistamines(AHs)and head and neck cancer(HNC)risk in patients with type 2 diabetes mellitus(T2DM).Data from the National Health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018.A propensity-score-matched cohort of 54,384 patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards regression.The results showed that the risk of HNC was significantly lower in AH users(adjusted hazard ratio:0.55,95%CI:0.48 to 0.64)and the incidence rate was also lower(5.16 vs.8.10 per 100,000 person-years).The lower HNC incidence rate in AH users(95%CI:0.63;0.55 to 0.73)suggests that AH use may reduce the risk of HNC in T2DM patients. 展开更多
关键词 Type 2 diabetes H1-Antihistamine Head and neck cancer INCIDENCE Incidence rate
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