OBJECTIVE:To explore the possible mechanism of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction(小续命汤,XXMD)in the treatment of Parkinson’s disease(PD).METHODS:C57BL/6 mice were randomly divided into ...OBJECTIVE:To explore the possible mechanism of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction(小续命汤,XXMD)in the treatment of Parkinson’s disease(PD).METHODS:C57BL/6 mice were randomly divided into eight groups(n=12),including blank group,model group,medication group,acupuncture group,high-dose XXMD group(XXMD-H),low-dose XXMD group(XXMD-L),acupuncture combined with high-dose XXMD group(A+H),and acupuncture combined with low-dose XXMD group(A+L).After treatment for 6 weeks,dopamine(DA)neurons and the pathological changes of tyrosine hydroxylase(TH)positive cells were observed.The enzyme-linked immunosorbent assay(ELISA)was used to measure the content of DA and the level of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor alpha(TNF-α).The m RNA level of PINK1 and Parkin and the protein expression of Nix,PINK1 and Parkin in the substantia nigra were also detected.RESULTS:Combination treatment effectively ameliorated the symptoms of PD.Compared with model group,combined treatment significantly up-regulated the protein expression of Nix,Parkin and PINK1 and the m RNA levels of PINK1 and Parkin in the substantia nigra(P<0.0001,P<0.001,P<0.01 or P<0.05).Furthermore,the levels of pro-inflammation cytokines were obviously decreased after combination therapy,while IL-10 content was increased remarkably(P<0.01).CONCLUSION:Compared with each treatment alone,combination therapy improved the pathological damage of DA neurons of PD mice more effectively.The possible mechanism may be attributed to the up-regulated level of mitochondrial autophagy and improved mitochondrial function.These results provide fresh insight into the mechanism of co-treatment with Tongdu Tiaoshen acupuncture and XXMD for PD.展开更多
The concept of the Solar Ring mission was gradually formed from L5/L4 mission concept, and the proposal of its pre-phase study was funded by the National Natural Science Foundation of China in November 2018 and then b...The concept of the Solar Ring mission was gradually formed from L5/L4 mission concept, and the proposal of its pre-phase study was funded by the National Natural Science Foundation of China in November 2018 and then by the Strategic Priority Program of Chinese Academy of Sciences in space sciences in May 2019. Solar Ring mission will be the first attempt to routinely monitor and study the Sun and inner heliosphere from a full 360-degree perspective in the ecliptic plane. The current preliminary design of the Solar Ring mission is to deploy six spacecraft, grouped in three pairs, on a sub-AU orbit around the Sun. The two spacecraft in each group are separated by about 30?and every two groups by about 120?. This configuration with necessary science payloads will allow us to establish three unprecedented capabilities:(1) determine the photospheric vector magnetic field with unambiguity,(2) provide 360-degree maps of the Sun and the inner heliosphere routinely, and(3) resolve the solar wind structures at multiple scales and multiple longitudes. With these capabilities, the Solar Ring mission aims to address the origin of solar cycle, the origin of solar eruptions, the origin of solar wind structures and the origin of severe space weather events. The successful accomplishment of the mission will advance our understanding of the star and the space environment that hold our life and enhance our capability of expanding the next new territory of human.展开更多
"Solar storm" has been commonly accepted by academic community and the public as a very popular scientific term. It is avivid description of violent ejections of a huge amount of magnetized plasma from the S..."Solar storm" has been commonly accepted by academic community and the public as a very popular scientific term. It is avivid description of violent ejections of a huge amount of magnetized plasma from the Sun as strong flare/CMEs, which sweepover into interplanetary space, develop, and affect our space environment. The solar storm could bring us disastrous spaceweather, destroy crucial technology, and cause a large-scale blackout. It is one of the natural disasters faced by modern humanbeings. Here we first briefly summarize the observational features of solar storms and introduce some key issues, and then wefocus on major advances in observational studies. We mainly introduce the efforts made by the Chinese scientists and comment on the challenges and opportunities that they are facing. In this era when scientific breakthroughs in solar storm studiescrucially depend on space-borne devices and large-aperture ground-based telescopes, the Chinese solar research communityneeds to develop its own major observational facilities and improve space weather forecasting abilities.展开更多
The flash spectra in the HeI D3 line were obtained during the 2008 total solar eclipse. This paper describes the instrument and the calibration of the obtained flash spectrum, and presents our initial results. The ave...The flash spectra in the HeI D3 line were obtained during the 2008 total solar eclipse. This paper describes the instrument and the calibration of the obtained flash spectrum, and presents our initial results. The average integrated intensity is Eave = 8.13×1013 erg·cm-1· s-1·ster-1 at h = 1100 km, which confirms that the HeI D3 emission is negatively correlated with the solar activity. The surface brightness reaches a maximum of F ave = 8.25×105 erg·cm-2·s-1·ster-1 at about h ≈ (1290 ± 75) km and then decreases exponentially with height when h >1800 km with an exponential index β = 1.63×10-8 cm-1.展开更多
基金Supported by National Natural Science Foundation of China:Study on the Mechanism of Regulating miR-124 by Tongdu Tiaoshen Acupuncture to Promote Neuroprotection in Cerebral Ischemia Reperfusion Injury(No.81973933)Natural Science Fund for Colleges and Universities in Anhui Province:Study on the Regulatory Mechanism of Tongdu Tiaoshen Acupuncture on Dopaminergic Neurons in Parkinson’s Disease Model Mice Based on Mitochondrial Autophagy(No.KJ2019A0475)。
文摘OBJECTIVE:To explore the possible mechanism of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction(小续命汤,XXMD)in the treatment of Parkinson’s disease(PD).METHODS:C57BL/6 mice were randomly divided into eight groups(n=12),including blank group,model group,medication group,acupuncture group,high-dose XXMD group(XXMD-H),low-dose XXMD group(XXMD-L),acupuncture combined with high-dose XXMD group(A+H),and acupuncture combined with low-dose XXMD group(A+L).After treatment for 6 weeks,dopamine(DA)neurons and the pathological changes of tyrosine hydroxylase(TH)positive cells were observed.The enzyme-linked immunosorbent assay(ELISA)was used to measure the content of DA and the level of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor alpha(TNF-α).The m RNA level of PINK1 and Parkin and the protein expression of Nix,PINK1 and Parkin in the substantia nigra were also detected.RESULTS:Combination treatment effectively ameliorated the symptoms of PD.Compared with model group,combined treatment significantly up-regulated the protein expression of Nix,Parkin and PINK1 and the m RNA levels of PINK1 and Parkin in the substantia nigra(P<0.0001,P<0.001,P<0.01 or P<0.05).Furthermore,the levels of pro-inflammation cytokines were obviously decreased after combination therapy,while IL-10 content was increased remarkably(P<0.01).CONCLUSION:Compared with each treatment alone,combination therapy improved the pathological damage of DA neurons of PD mice more effectively.The possible mechanism may be attributed to the up-regulated level of mitochondrial autophagy and improved mitochondrial function.These results provide fresh insight into the mechanism of co-treatment with Tongdu Tiaoshen acupuncture and XXMD for PD.
基金supported by the Strategic Priority Program of CAS (Grant Nos. XDB41000000 and XDA15017300)the National Natural Science Foundation of China (NSFC)(Grant No. 41842037)+5 种基金supported by the CAS Key Research Program of Frontier Sciences (Grant No. QYZDB-SSW-DQC015)the NSFC (Grant Nos. 417741784176113408841750110481 and 11925302)the NSFC (Grant No. 11790302)the NSFC (Grant No. 41627806)。
文摘The concept of the Solar Ring mission was gradually formed from L5/L4 mission concept, and the proposal of its pre-phase study was funded by the National Natural Science Foundation of China in November 2018 and then by the Strategic Priority Program of Chinese Academy of Sciences in space sciences in May 2019. Solar Ring mission will be the first attempt to routinely monitor and study the Sun and inner heliosphere from a full 360-degree perspective in the ecliptic plane. The current preliminary design of the Solar Ring mission is to deploy six spacecraft, grouped in three pairs, on a sub-AU orbit around the Sun. The two spacecraft in each group are separated by about 30?and every two groups by about 120?. This configuration with necessary science payloads will allow us to establish three unprecedented capabilities:(1) determine the photospheric vector magnetic field with unambiguity,(2) provide 360-degree maps of the Sun and the inner heliosphere routinely, and(3) resolve the solar wind structures at multiple scales and multiple longitudes. With these capabilities, the Solar Ring mission aims to address the origin of solar cycle, the origin of solar eruptions, the origin of solar wind structures and the origin of severe space weather events. The successful accomplishment of the mission will advance our understanding of the star and the space environment that hold our life and enhance our capability of expanding the next new territory of human.
基金supported by the National Basic Research Program of China (Grant Nos. 2011CB811402 and 2011CB811403)National Natural Science Foundation of China (Grant Nos. 11221063, 40890161 and 11173062)
文摘"Solar storm" has been commonly accepted by academic community and the public as a very popular scientific term. It is avivid description of violent ejections of a huge amount of magnetized plasma from the Sun as strong flare/CMEs, which sweepover into interplanetary space, develop, and affect our space environment. The solar storm could bring us disastrous spaceweather, destroy crucial technology, and cause a large-scale blackout. It is one of the natural disasters faced by modern humanbeings. Here we first briefly summarize the observational features of solar storms and introduce some key issues, and then wefocus on major advances in observational studies. We mainly introduce the efforts made by the Chinese scientists and comment on the challenges and opportunities that they are facing. In this era when scientific breakthroughs in solar storm studiescrucially depend on space-borne devices and large-aperture ground-based telescopes, the Chinese solar research communityneeds to develop its own major observational facilities and improve space weather forecasting abilities.
基金Supported by the National Natural Science Foundation of China (Grant Nos. 10843004, 10873038, and 10833007)the National Basic Research Program of China (Grant No. 2006CB806302)+1 种基金the CAS Project (Grant No. KJCX2-YW-T04)the China Meteorological Administration(Grant No. GYHY200706013)
文摘The flash spectra in the HeI D3 line were obtained during the 2008 total solar eclipse. This paper describes the instrument and the calibration of the obtained flash spectrum, and presents our initial results. The average integrated intensity is Eave = 8.13×1013 erg·cm-1· s-1·ster-1 at h = 1100 km, which confirms that the HeI D3 emission is negatively correlated with the solar activity. The surface brightness reaches a maximum of F ave = 8.25×105 erg·cm-2·s-1·ster-1 at about h ≈ (1290 ± 75) km and then decreases exponentially with height when h >1800 km with an exponential index β = 1.63×10-8 cm-1.
