Under the assumptions of triangular cross section channel and uniform stable flow, an analytical solution of the minimum ecological in-stream flow requirement （MEIFR） is deduced. Based on the analytical solution, th...Under the assumptions of triangular cross section channel and uniform stable flow, an analytical solution of the minimum ecological in-stream flow requirement （MEIFR） is deduced. Based on the analytical solution, the uncertainty of the wetted perimeter method is analyzed by comparing the two techniques for the determination of the critical point on the relationship curve between wetted perimeter, P and discharge, Q. It is clearly shown that the results of MEIFR based on curvature technique （corresponding to the maximum curvature） and slope technique （slope being 1） are significantly different. On the P-Q curve, the slope of the critical point with the maximum curvature is 0.39 and the MEIFR varied prominently with the change of the slope threshold. This indicates that if a certain value of the slope threshold is not available for slope technique, curvature technique may be a better choice. By applying the analytical solution of MEIFR in the losing rivers of the Western Route South-to-North Water Transfer Project in China, the MEIFR value via curvature technique is 2.5%-23.7% of the multi-year average annual discharge, while that for slope technique is 11%-105.7%. General conclusions would rely on the more detailed research for all kinds of cross-sections.展开更多
该患者为直肠癌多发转移[微卫星稳定(microsatellite stable,MSS)NRAS基因突变]且合并急性肠梗阻的复杂病例。在二线化学药物治疗失败后选择瑞戈非尼靶向治疗,部分病灶进展。继续联合应用程序性死亡蛋白-1(programmed cell death protei...该患者为直肠癌多发转移[微卫星稳定(microsatellite stable,MSS)NRAS基因突变]且合并急性肠梗阻的复杂病例。在二线化学药物治疗失败后选择瑞戈非尼靶向治疗,部分病灶进展。继续联合应用程序性死亡蛋白-1(programmed cell death protein-1,PD-1)抑制剂治疗后,疾病控制。同时该患者自三线治疗开始多数处于居家治疗状态,安全性好,极大地提高了依从性,为该类患者的临床治疗提供了思路。展开更多
基金National Natural Science Foundation of China, No. 90211007 No.50279049+1 种基金 Knowledge Innovation Project of IGSNRR, CAS, No.CXIOG-A04-12 No.CX10G-E01-08
文摘Under the assumptions of triangular cross section channel and uniform stable flow, an analytical solution of the minimum ecological in-stream flow requirement （MEIFR） is deduced. Based on the analytical solution, the uncertainty of the wetted perimeter method is analyzed by comparing the two techniques for the determination of the critical point on the relationship curve between wetted perimeter, P and discharge, Q. It is clearly shown that the results of MEIFR based on curvature technique （corresponding to the maximum curvature） and slope technique （slope being 1） are significantly different. On the P-Q curve, the slope of the critical point with the maximum curvature is 0.39 and the MEIFR varied prominently with the change of the slope threshold. This indicates that if a certain value of the slope threshold is not available for slope technique, curvature technique may be a better choice. By applying the analytical solution of MEIFR in the losing rivers of the Western Route South-to-North Water Transfer Project in China, the MEIFR value via curvature technique is 2.5%-23.7% of the multi-year average annual discharge, while that for slope technique is 11%-105.7%. General conclusions would rely on the more detailed research for all kinds of cross-sections.
文摘该患者为直肠癌多发转移[微卫星稳定(microsatellite stable,MSS)NRAS基因突变]且合并急性肠梗阻的复杂病例。在二线化学药物治疗失败后选择瑞戈非尼靶向治疗,部分病灶进展。继续联合应用程序性死亡蛋白-1(programmed cell death protein-1,PD-1)抑制剂治疗后,疾病控制。同时该患者自三线治疗开始多数处于居家治疗状态,安全性好,极大地提高了依从性,为该类患者的临床治疗提供了思路。
