The Dahutang tungsten polymetallic ore field is located north of the Nanling W-Sn polymetallic metallogenic belt and south of the Middle—Lower Yangtze River Valley Cu-Mo-Au-Fe porphyry-skarn belt.It is a newly discov...The Dahutang tungsten polymetallic ore field is located north of the Nanling W-Sn polymetallic metallogenic belt and south of the Middle—Lower Yangtze River Valley Cu-Mo-Au-Fe porphyry-skarn belt.It is a newly discovered ore field,and probably represents the largest tungsten mineralization district in the world.The Shimensi deposit is one of the mineral deposits in the Dahutang ore field,and is associated with Yanshanian granites intruding into a Neoproterozoic granodiorite batholith.On the basis of geologic studies,this paper presents new petrographic,microthermometric,laser Raman spectroscopic and hydrogen and oxygen isotopic studies of fluid inclusions from the Shimensi deposit.The results show that there are three types of fluid inclusions in quartz from various mineralization stages：liquid-rich two-phase fluid inclusions,vapor-rich two-phase fluid inclusions,and three-phase fluid inclusions containing a solid crystal,with the vast majority being liquid-rich two-phase fluid inclusions.In addition,melt and melt-fluid inclusions were also found in quartz from pegmatoid bodies in the margin of the Yanshanian intrusion.The homogenization temperatures of liquid-rich two-phase fluid inclusions in quartz range from 162 to 363℃ and salinities are 0.5wt%-9.5wt%NaCI equivalent.From the early to late mineralization stages,with the decreasing of the homogenization temperature,the salinity also shows a decreasing trend.The ore-forming fluids can be approximated by a NaCl-H_2O fluid system,with small amounts of volatile components including CO_2,CH_4 and N_2,as suggested by Laser Raman spectroscopic analyses.The hydrogen and oxygen isotope data show that δ5D_（V-smow） values of bulk fluid inclusions in quartz from various mineralization stages vary from-63.8‰ to-108.4‰,and the δ^（18）O_（H2O） values calculated from the δ^（18）O_（V-）smow values of quartz vary from-2.28‰ to 7.21‰.These H-O isotopic data are interpreted to indicate that the ore-forming fluids are mainly composed of magmatic water in the early stage,and meteoric water was added and participated in mineralization in the late stage.Integrating the geological characteristics and analytical data,we propose that the ore-forming fluids of the Shimensi deposit were mainly derived from Yanshanian granitic magma,the evolution of which resulted in highly differentiated melt,as recorded by melt and melt-fluid inclusions in pegmatoid quartz,and high concentrations of metals in the fluids.Cooling of the ore-forming fluids and mixing with meteoric water may be the key factors that led to mineralization in the Dahutang tungsten polymetallic ore field.展开更多
目的:筛选并分析影响成年大面积烧伤患者预后的危险因素及其预测预后的价值。方法:采用回顾性病例研究方法,纳入2013年1月-2022年1月,南京大学医学院附属鼓楼医院烧伤整形外科收治的76例成年大面积烧伤患者。根据患者的预后,分为存活组5...目的:筛选并分析影响成年大面积烧伤患者预后的危险因素及其预测预后的价值。方法:采用回顾性病例研究方法,纳入2013年1月-2022年1月,南京大学医学院附属鼓楼医院烧伤整形外科收治的76例成年大面积烧伤患者。根据患者的预后,分为存活组58例和死亡组18例,统计两组患者的临床基本资料及实验室检查结果:性别、年龄、烧伤原因、烧伤总面积,吸入性损伤情况、治疗期间是否行气管切开、CRRT等治疗;烧伤后第1、3天的中性粒细胞计数、淋巴细胞计数、血小板计数、中性粒细胞与淋巴细胞比值(Neutrophil to lymphocyte ratio,NLR)、血小板与淋巴细胞比值(Platelet to lymphocyte ratio,PLR);烧伤后第1天的C反应蛋白值、淋巴细胞与C反应蛋白比值(Lymphocyte-to-CRP ratio,LCR)及血肌酐值。通过二分类单因素和多因素Logistic回归分析,筛选出影响患者预后的危险因素和独立危险因素,并绘制患者死亡的独立危险因素对成年大面积烧伤患者预后预测的ROC曲线。结果:两组患者的烧伤总面积、合并吸入性损伤情况、有无行气管切开及CRRT治疗的比较,差异有统计学意义(P<0.05)。烧伤后第1天中性粒细胞计数、血小板计数、血肌酐值及烧伤后第3天血小板计数的比较,两组间差异有统计学意义(P<0.05)。二分类单因素Logistic回归分析显示,烧伤总面积、吸入性损伤、行气管切开、CRRT治疗、烧伤后第1天中性粒细胞计数、血小板计数、血肌酐值及烧伤后第3天血小板计数是成年大面积烧伤患者死亡的危险因素。多因素logistic回归分析显示,烧伤总面积与烧伤后第1天的血小板计数是成年大面积烧伤患者死亡的独立危险因素。烧伤总面积对76例成年大面积烧伤患者死亡预测的ROC曲线下面积为0.874(95%CI=0.785~0.962,P<0.001),其预测死亡的最佳阈值为83.5%TBSA,对应的灵敏度为72%,特异度为88%。烧伤总面积联合烧伤后第1天血小板计数对患者死亡预测的ROC曲线下面积为0.924(95%CI=0.847~1.000,P<0.001)。结论:烧伤总面积、烧伤后第1天血小板计数与成年大面积烧伤患者的预后密切相关,可作为评估此类患者预后的预测指标,当将二者联合考虑时对患者预后评估价值将会进一步提高,而NLR、PLR及LCR均不能很好地预测成年大面积烧伤患者的预后。展开更多
基金supported by the Old Mine Prospecting Technology Innovation and Demonstration Projects of China Geological Survey(No.1212011220737)
文摘The Dahutang tungsten polymetallic ore field is located north of the Nanling W-Sn polymetallic metallogenic belt and south of the Middle—Lower Yangtze River Valley Cu-Mo-Au-Fe porphyry-skarn belt.It is a newly discovered ore field,and probably represents the largest tungsten mineralization district in the world.The Shimensi deposit is one of the mineral deposits in the Dahutang ore field,and is associated with Yanshanian granites intruding into a Neoproterozoic granodiorite batholith.On the basis of geologic studies,this paper presents new petrographic,microthermometric,laser Raman spectroscopic and hydrogen and oxygen isotopic studies of fluid inclusions from the Shimensi deposit.The results show that there are three types of fluid inclusions in quartz from various mineralization stages：liquid-rich two-phase fluid inclusions,vapor-rich two-phase fluid inclusions,and three-phase fluid inclusions containing a solid crystal,with the vast majority being liquid-rich two-phase fluid inclusions.In addition,melt and melt-fluid inclusions were also found in quartz from pegmatoid bodies in the margin of the Yanshanian intrusion.The homogenization temperatures of liquid-rich two-phase fluid inclusions in quartz range from 162 to 363℃ and salinities are 0.5wt%-9.5wt%NaCI equivalent.From the early to late mineralization stages,with the decreasing of the homogenization temperature,the salinity also shows a decreasing trend.The ore-forming fluids can be approximated by a NaCl-H_2O fluid system,with small amounts of volatile components including CO_2,CH_4 and N_2,as suggested by Laser Raman spectroscopic analyses.The hydrogen and oxygen isotope data show that δ5D_（V-smow） values of bulk fluid inclusions in quartz from various mineralization stages vary from-63.8‰ to-108.4‰,and the δ^（18）O_（H2O） values calculated from the δ^（18）O_（V-）smow values of quartz vary from-2.28‰ to 7.21‰.These H-O isotopic data are interpreted to indicate that the ore-forming fluids are mainly composed of magmatic water in the early stage,and meteoric water was added and participated in mineralization in the late stage.Integrating the geological characteristics and analytical data,we propose that the ore-forming fluids of the Shimensi deposit were mainly derived from Yanshanian granitic magma,the evolution of which resulted in highly differentiated melt,as recorded by melt and melt-fluid inclusions in pegmatoid quartz,and high concentrations of metals in the fluids.Cooling of the ore-forming fluids and mixing with meteoric water may be the key factors that led to mineralization in the Dahutang tungsten polymetallic ore field.
文摘目的:筛选并分析影响成年大面积烧伤患者预后的危险因素及其预测预后的价值。方法:采用回顾性病例研究方法,纳入2013年1月-2022年1月,南京大学医学院附属鼓楼医院烧伤整形外科收治的76例成年大面积烧伤患者。根据患者的预后,分为存活组58例和死亡组18例,统计两组患者的临床基本资料及实验室检查结果:性别、年龄、烧伤原因、烧伤总面积,吸入性损伤情况、治疗期间是否行气管切开、CRRT等治疗;烧伤后第1、3天的中性粒细胞计数、淋巴细胞计数、血小板计数、中性粒细胞与淋巴细胞比值(Neutrophil to lymphocyte ratio,NLR)、血小板与淋巴细胞比值(Platelet to lymphocyte ratio,PLR);烧伤后第1天的C反应蛋白值、淋巴细胞与C反应蛋白比值(Lymphocyte-to-CRP ratio,LCR)及血肌酐值。通过二分类单因素和多因素Logistic回归分析,筛选出影响患者预后的危险因素和独立危险因素,并绘制患者死亡的独立危险因素对成年大面积烧伤患者预后预测的ROC曲线。结果:两组患者的烧伤总面积、合并吸入性损伤情况、有无行气管切开及CRRT治疗的比较,差异有统计学意义(P<0.05)。烧伤后第1天中性粒细胞计数、血小板计数、血肌酐值及烧伤后第3天血小板计数的比较,两组间差异有统计学意义(P<0.05)。二分类单因素Logistic回归分析显示,烧伤总面积、吸入性损伤、行气管切开、CRRT治疗、烧伤后第1天中性粒细胞计数、血小板计数、血肌酐值及烧伤后第3天血小板计数是成年大面积烧伤患者死亡的危险因素。多因素logistic回归分析显示,烧伤总面积与烧伤后第1天的血小板计数是成年大面积烧伤患者死亡的独立危险因素。烧伤总面积对76例成年大面积烧伤患者死亡预测的ROC曲线下面积为0.874(95%CI=0.785~0.962,P<0.001),其预测死亡的最佳阈值为83.5%TBSA,对应的灵敏度为72%,特异度为88%。烧伤总面积联合烧伤后第1天血小板计数对患者死亡预测的ROC曲线下面积为0.924(95%CI=0.847~1.000,P<0.001)。结论:烧伤总面积、烧伤后第1天血小板计数与成年大面积烧伤患者的预后密切相关,可作为评估此类患者预后的预测指标,当将二者联合考虑时对患者预后评估价值将会进一步提高,而NLR、PLR及LCR均不能很好地预测成年大面积烧伤患者的预后。
