Objective:To investigate the effects of Jiangan Xiaozhi Formula(JGXZ)on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease(NAFLD).Methods:Between September 2022 and December 2...Objective:To investigate the effects of Jiangan Xiaozhi Formula(JGXZ)on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease(NAFLD).Methods:Between September 2022 and December 2023,our hospital admitted a total of 58 patients with NAFLD.These patients were split into two groups at random:one for experimentation and the other for control.There were 27 patients in the experimental group at the end,compared to 26 in the control group,reasonable exercise,weight management,lipid regulation,and oral polyene phosphatidylcholine capsules(PPC).The experimental group received JGXZ in addition to the above treatments for 12 consecutive weeks.Changes in Traditional Chinese Medicine(TCM)syndrome scores,blood lipids,liver function indicators,the levels of oxidative stress markers,such as malondialdehyde(MDA),glutathione peroxidase(GSH-Px),and superoxide dismutase(SOD),as well as serum inflammatory factors,such as interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α),were measured both before and after treatment.Results:After treatment,both groups showed significant reductions in TCM syndrome scores(P<0.05)and improvements in blood lipids,liver function indicators,inflammatory factors,and oxidative stress markers(P<0.05).Improvements were noticeably better in the experimental group than in the control group.(P<0.05).Conclusion:JGXZ can significantly improve clinical symptoms,regulate blood lipids,and protect liver function in patients with NAFLD.Its mechanism may be related to inhibiting inflammatory responses and regulating the balance of the oxidation-antioxidation system.展开更多
This study investigates the temperature inversion phenomenon in the Zhujiang(Pearl) River Estuary(ZRE) using hydrological data collected in a summer cruise during July 6–17, 2015. The results suggest that temperature...This study investigates the temperature inversion phenomenon in the Zhujiang(Pearl) River Estuary(ZRE) using hydrological data collected in a summer cruise during July 6–17, 2015. The results suggest that temperature inversion occurred primarily near the salinity front, with an average temperature difference(ΔT) of 0.42°C between the inversion layer and the underlying water. The inversion layer was approximately 4 m thick on average, with an upper boundary at a depth of 1–6 m and a lower boundary at a depth of 3–10 m. Different mechanisms and dynamic processes were responsible for temperature inversion in different parts of the study area.(1) At the salinity front in the west of the ZRE, the measurements collected by CTD(conductivity,temperature, and depth) showed that the low-salinity water mass on the inner side of the front was approximately2°C cooler than the high-salinity water mass on the outer side. Temperature inversion occurred when the cooler low-salinity water overlapped the warmer high-salinity water near the front due to the driving force of the background flow.(2) Inversion layers occurred at the mouth of the Taiping waterway as a result of varying horizontal flow between two different water masses under the effects of tides and runoff.(3) To the southwest of Hong Kong, temperature inversion occurred due to the interaction of upwelling and the salinity front.展开更多
In this paper, we focus on the power allocation of Integrated Sensing and Communication(ISAC) with orthogonal frequency division multiplexing(OFDM) waveform. In order to improve the spectrum utilization efficiency in ...In this paper, we focus on the power allocation of Integrated Sensing and Communication(ISAC) with orthogonal frequency division multiplexing(OFDM) waveform. In order to improve the spectrum utilization efficiency in ISAC, we propose a design scheme based on spectrum sharing, that is,to maximize the mutual information(MI) of radar sensing while ensuring certain communication rate and transmission power constraints. In the proposed scheme, three cases are considered for the scattering off the target due to the communication signals,as negligible signal, beneficial signal, and interference signal to radar sensing, respectively, thus requiring three power allocation schemes. However,the corresponding power allocation schemes are nonconvex and their closed-form solutions are unavailable as a consequence. Motivated by this, alternating optimization(AO), sequence convex programming(SCP) and Lagrange multiplier are individually combined for three suboptimal solutions corresponding with three power allocation schemes. By combining the three algorithms, we transform the non-convex problem which is difficult to deal with into a convex problem which is easy to solve and obtain the suboptimal solution of the corresponding optimization problem. Numerical results show that, compared with the allocation results of the existing algorithms, the proposed joint design algorithm significantly improves the radar performance.展开更多
Background:To investigate the pharmacological effects of Fangshi Jiangtang decoction(FSJT)on type 2 diabetes mellitus(T2DM)model rats and explore its mechanism of action from the perspective of mitochondrial autophagy...Background:To investigate the pharmacological effects of Fangshi Jiangtang decoction(FSJT)on type 2 diabetes mellitus(T2DM)model rats and explore its mechanism of action from the perspective of mitochondrial autophagy.Methods:Sixty Sprague Dawley rats were randomly divided into six groups after one week of adaptive feeding:Control group,T2DM model group,metformin group(0.2 g/kg by gavage),and FSJT low,medium,and high dose groups(9.5,19,38 g/kg by gavage).Except for the Control group,the other five groups were given a high-fat diet.The treatment lasted for 8 weeks,and blood glucose levels were measured weekly.Eight weeks later,blood samples were collected from the rats,and serum was separated for the determination of HbA1c,oral glucose tolerance test,and homeostatic model assessment for insulin resistance index.The pancreas of the rats was collected,weighed,and fixed.The same part of the pancreas was used for hematoxylin-eosin.Kits were used to detect triglycerides,total cholesterol,interleukin-1β,interleukin-6,tumor necrosis factor-α,malondialdehyde,glutathione peroxidase,and superoxide dismutase in pancreatic tissue to assess the effects of FSJT on inflammation and oxidative stress in T2DM rats.Western blot analysis was performed to detect the expression of VDAC1,TOM20,COXⅣ,PINK1,Parkin,beclin1,light chain 3,and selective autophagy adaptor protein P62 to evaluate the effects of FSJT on mitochondrial autophagy in T2DM model rats.Results:Compared with the T2DM model group,FSJT intervention significantly reduced blood glucose,HbA1c,oral glucose tolerance test,and homeostatic model assessment for insulin resistance index in T2DM model rats,alleviated pancreatic tissue lesions,reduced levels of total cholesterol,triglycerides,interleukin-1β,interleukin-6,tumor necrosis factor-α,and malondialdehyde,increased glutathione peroxidase and superoxide dismutase activities,downregulated the expression of VDAC1,TOM20,COXⅣ,and P62 proteins,and upregulated the expression of PINK1,Parkin,Beclin1,and light chain 3 proteins.Conclusion:FSJT can improve insulin resistance in T2DM by promoting the activation of mitochondrial autophagy.展开更多
Video captioning aims at automatically generating a natural language caption to describe the content of a video.However,most of the existing methods in the video captioning task ignore the relationship between objects...Video captioning aims at automatically generating a natural language caption to describe the content of a video.However,most of the existing methods in the video captioning task ignore the relationship between objects in the video and the correlation between multimodal features,and they also ignore the effect of caption length on the task.This study proposes a novel video captioning framework(ORMF)based on the object relation graph and multimodal feature fusion.ORMF uses the similarity and Spatio-temporal relationship of objects in video to construct object relation features graph and introduce graph convolution network(GCN)to encode the object relation.At the same time,ORMF also constructs a multimodal features fusion network to learn the relationship between different modal features.The multimodal feature fusion network is used to fuse the features of different modals.Furthermore,the proposed model calculates the length loss of the caption,making the caption get richer information.The experimental results on two public datasets(Microsoft video captioning corpus[MSVD]and Microsoft research-video to text[MSR-VTT])demonstrate the effectiveness of our method.展开更多
Recent text generation methods frequently learn node representations from graph‐based data via global or local aggregation,such as knowledge graphs.Since all nodes are connected directly,node global representation en...Recent text generation methods frequently learn node representations from graph‐based data via global or local aggregation,such as knowledge graphs.Since all nodes are connected directly,node global representation encoding enables direct communication between two distant nodes while disregarding graph topology.Node local representation encoding,which captures the graph structure,considers the connections between nearby nodes but misses out onlong‐range relations.A quantum‐like approach to learning bettercontextualised node embeddings is proposed using a fusion model that combines both encoding strategies.Our methods significantly improve on two graph‐to‐text datasets compared to state‐of‐the‐art models in various experiments.展开更多
The classification of the springtime water mass has an important influence on the hydrography,regional climate change and fishery in the Taiwan Strait.Based on 58 stations of CTD profiling data collected in the wester...The classification of the springtime water mass has an important influence on the hydrography,regional climate change and fishery in the Taiwan Strait.Based on 58 stations of CTD profiling data collected in the western and southwestern Taiwan Strait during the spring cruise of 2019,we analyze the spatial distributions of temperature(T)and salinity(S)in the investigation area.Then by using the fuzzy cluster method combined with the T-S similarity number,we classify the investigation area into 5 water masses:the Minzhe Coastal Water(MZCW),the Taiwan Strait Mixed Water(TSMW),the South China Sea Surface Water(SCSSW),the South China Sea Subsurface Water(SCSUW)and the Kuroshio Branch Water(KBW).The MZCW appears in the near surface layer along the western coast of Taiwan Strait,showing low-salinity(<32.0)tongues near the Minjiang River Estuary and the Xiamen Bay mouth.The TSMW covers most upper layer of the investigation area.The SCSSW is mainly distributed in the upper layer of the southwestern Taiwan Strait,beneath which is the SCSUW.The KBW is a high temperature(core value of 26.36℃)and high salinity(core value of 34.62)water mass located southeast of the Taiwan Bank and partially in the central Taiwan Strait.展开更多
In this paper,we investigate the system performance of a heterogeneous cellular network consisting of a macro cell and a small cell,where each cell has one user and one base station with multiple antennas.The macro ba...In this paper,we investigate the system performance of a heterogeneous cellular network consisting of a macro cell and a small cell,where each cell has one user and one base station with multiple antennas.The macro base station(MBS)and the small base station(SBS)transmit their confidential messages to the macro user(MU)and the small user(SU)over their shared spectrum respectively.To enhance the system sum rate(SSR)of MBS-MU and SBS-SU transmission,we propose joint antenna selection combined with optimal power allocation(JAS-OPA)scheme and independent antenna selection combined with optimal power allocation(IAS-OPA)scheme.The JAS-OPA scheme requires to know the channel state information(CSI)of transmission channels and interference channels,while the IAS-OPA scheme only needs to know the CSI of transmission channels.In addition,we carry out the analysis for conventional round-robin antenna selection combined with optimal power allocation(RR-OPA)as a benchmark scheme.We formulate the SSR maximization problem through the power allocation between MBS and SBS and propose iterative OPA algorithms for JAS-OPA,IAS-OPA and RR-OPA schemes,respectively.The results show that the OPA schemes outperform the equal power allocation in terms of SSR.Moreover,we provide the closed-form expression of the system outage probability(SOP)for IAS scheme and RR scheme,it shows the SOP performance can be significantly improved by our proposed IAS scheme compared with RR scheme.展开更多
Interfacial solar steam generation(ISSG)is a novel and potential solution to global freshwater crisis.Here,based on a facile sol-gel fabrication process,we demonstrate a highly scalable Janus aramid nanofiber aerogel(...Interfacial solar steam generation(ISSG)is a novel and potential solution to global freshwater crisis.Here,based on a facile sol-gel fabrication process,we demonstrate a highly scalable Janus aramid nanofiber aerogel(JANA)as a high-efficiency ISSG device.JANA performs near-perfect broadband optical absorption,rapid photothermal conversion and effective water transportation.Owning to these features,efficient desalination of salty water and purification of municipal sewage are successfully demonstrated using JANA.In addition,benefiting from the mechanical property and chemical stability of constituent aramid nanofibers,JANA not only possesses outstanding flexibility and fire-resistance properties,but its solar steaming efficiency is also free from the influences of elastic deformations and fire treatments.We envision JANA provides a promising platform for mass-production of high-efficiency ISSG devices with supplementary capabilities of convenient transportation and long-term storage,which could further promote the realistic applications of ISSG technology.展开更多
Using the fuzzy cluster analysis and the temperature-salinity(T-S) similarity number analysis of cruise conductivity-temperature-depth(CTD) data in the upper layer(0–300 m) of the northern South China Sea(NSCS), we c...Using the fuzzy cluster analysis and the temperature-salinity(T-S) similarity number analysis of cruise conductivity-temperature-depth(CTD) data in the upper layer(0–300 m) of the northern South China Sea(NSCS), we classify the upper layer water of the NSCS into six water masses: diluted water(D), surface water(SS),the SCS subsurface water mass(U_S), the Pacific Ocean subsurface water mass(U_P), surface-subsurface mixed water(SU) and subsurface-intermediate mixed water(UI). A new stacked stereogram is used to illustrate the water mass distribution, and to examine the source and the distribution of U_P, combining with the sea surface height data and geostrophic current field. The results show that water mass U_P exists in all four seasons with the maximum range in spring and the minimum range in summer. In spring and winter, the U_P intrudes into the Luzon Strait and the southwest of Taiwan Island via the northern Luzon Strait in the form of nonlinear Rossby eddies, and forms a high temperature and high salinity zone east of the Dongsha Islands. In summer, the U_P is sporadically distributed in the study area. In autumn, the U_P is located in the upper 200 m layer east of Hainan Island.展开更多
Introduction: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neur...Introduction: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South China.Methods: In this retrospective case?based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in Sun Yat?sen University Cancer Center between January 2004 and May 2013 were included. The incidence, risk factors, and survival status of these patients were reviewed and analyzed.Results: Of the 106 patients, 11(10.4%) developed brain metastasis, accounting for 20.0% of 55 patients with relapse or progression. The age at initial diagnosis of the 11 patients ranged from 2 to 10 years(median 4 years), which was younger than that of the patients without brain metastasis(median 5 years, range 1–10 years, P = 0.073). The male to female ratio of the 11 patients was 8:3, which was not signiicantly diferent from that of the patients with?out brain metastasis(P = 0.86). Patients with brain metastasis had higher lactate dehydrogenase levels than those without brain metastasis, but the diferences were not signiicant(P initial diagnosis to the develo= 0.076). Eight patients died, and 3 patients survived. The median interval from thepment of brain metastasis was 18 months(range 6–32 months). The median survival was 4 months(range 1 day to 29 months) after the diagnosis of brain metastasis. The median interval from the manifestation of brain metastasis to death was 3 months(range 1 day to 11 months).Conclusions: High?risk factors for brain metastasis in cases of neuroblastoma include bone marrow involvement and a younger age at initial diagnosis. Nevertheless, multiple treatment modalities can improve disease?free survival.展开更多
For children with stage II testicular malignant germ cell tumors(MGCT), the survival is good with surgery and adjuvant chemotherapy. However, there is limited data on surgical results for cases in which there was no i...For children with stage II testicular malignant germ cell tumors(MGCT), the survival is good with surgery and adjuvant chemotherapy. However, there is limited data on surgical results for cases in which there was no imaging or pathologic evidence of residual tumor, but in which serum tumor markers either increased or failed to normalize after an appropriate period of half-life time post-surgery. To determine the use of chemotherapy for children with stage II germ cell tumors, we analyzed the outcomes(relapse rate and overall survival) of patients who were treated at the Sun Yat-sen University Cancer Center between January 1990 and May 2013. Twenty-four pediatric patients with a median age of 20 months(range, 4 months to 17 years) were enrolled in this study. In 20 cases(83.3%), the tumors had yolk sac histology. For definitive treatment, 21 patients underwent surgery alone, and 3 patients received surgery and adjuvant chemotherapy. No relapse was observed in the 3 patients who received adjuvant chemotherapy, whereas relapse occurred in 16 of the 21 patients(76.2%) treated with surgery alone. There were a total of 2 deaths. Treatment was stopped for 1 patient, who died 3 months later due to the tumor. The other patient achieved complete response after salvage treatment, but developed lung and pelvic metastases 7 months later and died of the tumor after stopping treatment. For children treated with surgery alone and surgery combined with adjuvant chemotherapy, the 3-year event-free survival rates were 23.8% and 100%, respectively(P = 0.042), and the 3-year overall survival rates were 90.5% and 100%, respectively(P = 0.588). These results suggest that adjuvant chemotherapy can help to reduce the recurrence rate and increase the survival rate for patients with stage II germ cell tumors.展开更多
Primary central nervous system germ cell tumors(CNS-GCTs) in children and adolescents have unique clinical features and methods of treatment compared with those in adults. There is little information about Chinese chi...Primary central nervous system germ cell tumors(CNS-GCTs) in children and adolescents have unique clinical features and methods of treatment compared with those in adults. There is little information about Chinese children and adolescents with CNS-GCTs. Therefore, in this study we retrospectively analyzed the clinical features and treatment outcome of Chinese children and adolescents with primary CNS-GCTs. Between January 2002 and December 2012, 57 untreated patients from a single institution were enrolled. They were diagnosed with CNS-GCTs after pathologic or clinical assessment. Of the 57 patients, 41 were males and 16 were females, with a median age of 12.8 years(range, 2.7 to 18.0 years) at diagnosis; 43(75.4%) had non-germinomatous germ cell tumors(NGGCTs) and 14(24.6%) had germinomas; 44(77.2%) had localized disease and 13(22.8%) had extensive lesions. Fifty-three patients completed the prescribed treatment, of which 18 underwent monotherapy of surgery, radiotherapy, or chemotherapy, and 35 underwent multimodality therapies that included radiotherapy combined with chemotherapy or surgery combined with chemotherapy and/or radiotherapy. PEB(cisplatin, etoposide, and bleomycin) protocol was the major chemotherapy regimen. The median follow-up time was 32.3 months(range, 1.2 to 139 months). Fourteen patients died of relapse or disease progression. The 3-year event-free survival(EFS) and overall survival rates for all patients were 72.2% and 73.8%, respectively. The 3-year EFS was 92.9% for germinomas and 64.8% for NGGCTs(P = 0.064). The 3-year EFS rates for patients with NGGCTs who underwent monotherapy and multimodality therapies were 50.6% and 73.5%, respectively(P = 0.042). Our results indicate that multimodality therapies including chemotherapy plus radiotherapy were better treatment option for children and adolescents with CNS-GCTs.展开更多
Directed at the problem of occlusion in target tracking,a new improved algorithm based on the Meanshift algorithm and Kalman filter is proposed.The algorithm effectively combines the Meanshift algorithm with the Kalma...Directed at the problem of occlusion in target tracking,a new improved algorithm based on the Meanshift algorithm and Kalman filter is proposed.The algorithm effectively combines the Meanshift algorithm with the Kalman filtering algorithm to determine the position of the target centroid and subsequently adjust the current search window adaptively according to the target centroid position and the previous frame search window boundary.The derived search window is more closely matched to the location of the target,which improves the accuracy and reliability of tracking.The environmental influence and other influencing factors on the algorithm are also reduced.Through comparison and analysis of the experiments,the modified algorithm demonstrates good stability and adaptability,and can effectively solve the problem of large area occlusion and similar interference.展开更多
The grain surfaces(film surface and grain boundary)of polycrystalline perovskite films are vulnerable sites in solar cells since they pose a high defect density and initiate the degradation of perovskite absorber.Achi...The grain surfaces(film surface and grain boundary)of polycrystalline perovskite films are vulnerable sites in solar cells since they pose a high defect density and initiate the degradation of perovskite absorber.Achieving simultaneously defect passivation and grain protection from moisture is crucial for the viability of perovskite solar cells.Here,an in situ cross-linked grain encapsulation(CLGE)strategy that improves both device stability and defect passivation is reported.Cross-linkable semiconducting small molecules are mixed into the antisolvent to uniformly form a compact and conducting cross-linked layer over the grain surfaces.This cross-linked coating layer not only passivates trap states and facilitates hole extraction,but also enhances the device stability by preventing moisture diffusion.Using the CLGE strategy,a high power conversion efficiency(PCE)of 22.7%is obtained in 1.55-eV bandgap planar perovskite solar cells.The unencapsulated devices with CLGE exhibit significantly enhanced device stability again moisture and maintain>90%of their initial PCE after shelf storage under ambient condition for over10,000 h.展开更多
基金supported by National Natural Science Foundation of China,Youth Science Fund Project(82104820)Zhejiang Natural Science Foundation Project(LTGY23H270009)+1 种基金Applied Basic Research Project of Jiaxing Science and Technology Bureau(2023AY11035)Applied Basic Research Project of Jiaxing Science and Technology Bureau(2023AD11047).
文摘Objective:To investigate the effects of Jiangan Xiaozhi Formula(JGXZ)on oxidative stress and inflammatory factors in patients with non-alcoholic fatty liver disease(NAFLD).Methods:Between September 2022 and December 2023,our hospital admitted a total of 58 patients with NAFLD.These patients were split into two groups at random:one for experimentation and the other for control.There were 27 patients in the experimental group at the end,compared to 26 in the control group,reasonable exercise,weight management,lipid regulation,and oral polyene phosphatidylcholine capsules(PPC).The experimental group received JGXZ in addition to the above treatments for 12 consecutive weeks.Changes in Traditional Chinese Medicine(TCM)syndrome scores,blood lipids,liver function indicators,the levels of oxidative stress markers,such as malondialdehyde(MDA),glutathione peroxidase(GSH-Px),and superoxide dismutase(SOD),as well as serum inflammatory factors,such as interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α),were measured both before and after treatment.Results:After treatment,both groups showed significant reductions in TCM syndrome scores(P<0.05)and improvements in blood lipids,liver function indicators,inflammatory factors,and oxidative stress markers(P<0.05).Improvements were noticeably better in the experimental group than in the control group.(P<0.05).Conclusion:JGXZ can significantly improve clinical symptoms,regulate blood lipids,and protect liver function in patients with NAFLD.Its mechanism may be related to inhibiting inflammatory responses and regulating the balance of the oxidation-antioxidation system.
基金The National Basic Research Program of China under contract No.2015CB954004the National Natural Science Foundation of China under contract Nos 41776027,41606009 and U1405233
文摘This study investigates the temperature inversion phenomenon in the Zhujiang(Pearl) River Estuary(ZRE) using hydrological data collected in a summer cruise during July 6–17, 2015. The results suggest that temperature inversion occurred primarily near the salinity front, with an average temperature difference(ΔT) of 0.42°C between the inversion layer and the underlying water. The inversion layer was approximately 4 m thick on average, with an upper boundary at a depth of 1–6 m and a lower boundary at a depth of 3–10 m. Different mechanisms and dynamic processes were responsible for temperature inversion in different parts of the study area.(1) At the salinity front in the west of the ZRE, the measurements collected by CTD(conductivity,temperature, and depth) showed that the low-salinity water mass on the inner side of the front was approximately2°C cooler than the high-salinity water mass on the outer side. Temperature inversion occurred when the cooler low-salinity water overlapped the warmer high-salinity water near the front due to the driving force of the background flow.(2) Inversion layers occurred at the mouth of the Taiping waterway as a result of varying horizontal flow between two different water masses under the effects of tides and runoff.(3) To the southwest of Hong Kong, temperature inversion occurred due to the interaction of upwelling and the salinity front.
文摘In this paper, we focus on the power allocation of Integrated Sensing and Communication(ISAC) with orthogonal frequency division multiplexing(OFDM) waveform. In order to improve the spectrum utilization efficiency in ISAC, we propose a design scheme based on spectrum sharing, that is,to maximize the mutual information(MI) of radar sensing while ensuring certain communication rate and transmission power constraints. In the proposed scheme, three cases are considered for the scattering off the target due to the communication signals,as negligible signal, beneficial signal, and interference signal to radar sensing, respectively, thus requiring three power allocation schemes. However,the corresponding power allocation schemes are nonconvex and their closed-form solutions are unavailable as a consequence. Motivated by this, alternating optimization(AO), sequence convex programming(SCP) and Lagrange multiplier are individually combined for three suboptimal solutions corresponding with three power allocation schemes. By combining the three algorithms, we transform the non-convex problem which is difficult to deal with into a convex problem which is easy to solve and obtain the suboptimal solution of the corresponding optimization problem. Numerical results show that, compared with the allocation results of the existing algorithms, the proposed joint design algorithm significantly improves the radar performance.
基金supported by Applied Basic Research Project of Jiaxing Science and Technology Bureau(2023AD11047)the Joint Project of Yunnan Provincial Science and Technology Department and Yunnan University of Chinese Medicine(202101AZ070001-064).
文摘Background:To investigate the pharmacological effects of Fangshi Jiangtang decoction(FSJT)on type 2 diabetes mellitus(T2DM)model rats and explore its mechanism of action from the perspective of mitochondrial autophagy.Methods:Sixty Sprague Dawley rats were randomly divided into six groups after one week of adaptive feeding:Control group,T2DM model group,metformin group(0.2 g/kg by gavage),and FSJT low,medium,and high dose groups(9.5,19,38 g/kg by gavage).Except for the Control group,the other five groups were given a high-fat diet.The treatment lasted for 8 weeks,and blood glucose levels were measured weekly.Eight weeks later,blood samples were collected from the rats,and serum was separated for the determination of HbA1c,oral glucose tolerance test,and homeostatic model assessment for insulin resistance index.The pancreas of the rats was collected,weighed,and fixed.The same part of the pancreas was used for hematoxylin-eosin.Kits were used to detect triglycerides,total cholesterol,interleukin-1β,interleukin-6,tumor necrosis factor-α,malondialdehyde,glutathione peroxidase,and superoxide dismutase in pancreatic tissue to assess the effects of FSJT on inflammation and oxidative stress in T2DM rats.Western blot analysis was performed to detect the expression of VDAC1,TOM20,COXⅣ,PINK1,Parkin,beclin1,light chain 3,and selective autophagy adaptor protein P62 to evaluate the effects of FSJT on mitochondrial autophagy in T2DM model rats.Results:Compared with the T2DM model group,FSJT intervention significantly reduced blood glucose,HbA1c,oral glucose tolerance test,and homeostatic model assessment for insulin resistance index in T2DM model rats,alleviated pancreatic tissue lesions,reduced levels of total cholesterol,triglycerides,interleukin-1β,interleukin-6,tumor necrosis factor-α,and malondialdehyde,increased glutathione peroxidase and superoxide dismutase activities,downregulated the expression of VDAC1,TOM20,COXⅣ,and P62 proteins,and upregulated the expression of PINK1,Parkin,Beclin1,and light chain 3 proteins.Conclusion:FSJT can improve insulin resistance in T2DM by promoting the activation of mitochondrial autophagy.
基金The National Natural Science Foundation of China under Grant,Grant/Award Number:62077015National Natural Science Foundation of ChinaZhejiang Normal University。
文摘Video captioning aims at automatically generating a natural language caption to describe the content of a video.However,most of the existing methods in the video captioning task ignore the relationship between objects in the video and the correlation between multimodal features,and they also ignore the effect of caption length on the task.This study proposes a novel video captioning framework(ORMF)based on the object relation graph and multimodal feature fusion.ORMF uses the similarity and Spatio-temporal relationship of objects in video to construct object relation features graph and introduce graph convolution network(GCN)to encode the object relation.At the same time,ORMF also constructs a multimodal features fusion network to learn the relationship between different modal features.The multimodal feature fusion network is used to fuse the features of different modals.Furthermore,the proposed model calculates the length loss of the caption,making the caption get richer information.The experimental results on two public datasets(Microsoft video captioning corpus[MSVD]and Microsoft research-video to text[MSR-VTT])demonstrate the effectiveness of our method.
基金supported by the National Natural Science Foundation of China under Grant(62077015)the Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province,Zhejiang Normal University,Zhejiang,China,the Key Research and Development Program of Zhejiang Province(No.2021C03141)the National Key R&D Program of China under Grant(2022YFC3303600).
文摘Recent text generation methods frequently learn node representations from graph‐based data via global or local aggregation,such as knowledge graphs.Since all nodes are connected directly,node global representation encoding enables direct communication between two distant nodes while disregarding graph topology.Node local representation encoding,which captures the graph structure,considers the connections between nearby nodes but misses out onlong‐range relations.A quantum‐like approach to learning bettercontextualised node embeddings is proposed using a fusion model that combines both encoding strategies.Our methods significantly improve on two graph‐to‐text datasets compared to state‐of‐the‐art models in various experiments.
基金The National Natural Science Foundation of China under contract Nos 42106005,91958203,41676131,41876155.
文摘The classification of the springtime water mass has an important influence on the hydrography,regional climate change and fishery in the Taiwan Strait.Based on 58 stations of CTD profiling data collected in the western and southwestern Taiwan Strait during the spring cruise of 2019,we analyze the spatial distributions of temperature(T)and salinity(S)in the investigation area.Then by using the fuzzy cluster method combined with the T-S similarity number,we classify the investigation area into 5 water masses:the Minzhe Coastal Water(MZCW),the Taiwan Strait Mixed Water(TSMW),the South China Sea Surface Water(SCSSW),the South China Sea Subsurface Water(SCSUW)and the Kuroshio Branch Water(KBW).The MZCW appears in the near surface layer along the western coast of Taiwan Strait,showing low-salinity(<32.0)tongues near the Minjiang River Estuary and the Xiamen Bay mouth.The TSMW covers most upper layer of the investigation area.The SCSSW is mainly distributed in the upper layer of the southwestern Taiwan Strait,beneath which is the SCSUW.The KBW is a high temperature(core value of 26.36℃)and high salinity(core value of 34.62)water mass located southeast of the Taiwan Bank and partially in the central Taiwan Strait.
基金supported by National Natural Science Foundation of China(No.62071253)Postgraduate Research and Practice Innovation Program of Jiangsu Province(KYCX210747).
文摘In this paper,we investigate the system performance of a heterogeneous cellular network consisting of a macro cell and a small cell,where each cell has one user and one base station with multiple antennas.The macro base station(MBS)and the small base station(SBS)transmit their confidential messages to the macro user(MU)and the small user(SU)over their shared spectrum respectively.To enhance the system sum rate(SSR)of MBS-MU and SBS-SU transmission,we propose joint antenna selection combined with optimal power allocation(JAS-OPA)scheme and independent antenna selection combined with optimal power allocation(IAS-OPA)scheme.The JAS-OPA scheme requires to know the channel state information(CSI)of transmission channels and interference channels,while the IAS-OPA scheme only needs to know the CSI of transmission channels.In addition,we carry out the analysis for conventional round-robin antenna selection combined with optimal power allocation(RR-OPA)as a benchmark scheme.We formulate the SSR maximization problem through the power allocation between MBS and SBS and propose iterative OPA algorithms for JAS-OPA,IAS-OPA and RR-OPA schemes,respectively.The results show that the OPA schemes outperform the equal power allocation in terms of SSR.Moreover,we provide the closed-form expression of the system outage probability(SOP)for IAS scheme and RR scheme,it shows the SOP performance can be significantly improved by our proposed IAS scheme compared with RR scheme.
基金jointly supported by the National Natural Science Foundation of China (no. 62105142)Natural Science Foundation of Jiangsu Province (BK20220068)+1 种基金the Center Fundamental Research Funds for the Central UniversitiesEntrepreneurship and Innovation Program of Jiangsu Province (JSSCBS20210002)。
文摘Interfacial solar steam generation(ISSG)is a novel and potential solution to global freshwater crisis.Here,based on a facile sol-gel fabrication process,we demonstrate a highly scalable Janus aramid nanofiber aerogel(JANA)as a high-efficiency ISSG device.JANA performs near-perfect broadband optical absorption,rapid photothermal conversion and effective water transportation.Owning to these features,efficient desalination of salty water and purification of municipal sewage are successfully demonstrated using JANA.In addition,benefiting from the mechanical property and chemical stability of constituent aramid nanofibers,JANA not only possesses outstanding flexibility and fire-resistance properties,but its solar steaming efficiency is also free from the influences of elastic deformations and fire treatments.We envision JANA provides a promising platform for mass-production of high-efficiency ISSG devices with supplementary capabilities of convenient transportation and long-term storage,which could further promote the realistic applications of ISSG technology.
基金The National Natural Science Foundation of China under contract No.41776027the National Basic Research Program of China under contract Nos 2015CB954004 and 2009CB421208the Open Fund of the Key Laboratory of Ocean Circulation and Waves,Chinese Academy of Sciences under contract No.KLOCW1808
文摘Using the fuzzy cluster analysis and the temperature-salinity(T-S) similarity number analysis of cruise conductivity-temperature-depth(CTD) data in the upper layer(0–300 m) of the northern South China Sea(NSCS), we classify the upper layer water of the NSCS into six water masses: diluted water(D), surface water(SS),the SCS subsurface water mass(U_S), the Pacific Ocean subsurface water mass(U_P), surface-subsurface mixed water(SU) and subsurface-intermediate mixed water(UI). A new stacked stereogram is used to illustrate the water mass distribution, and to examine the source and the distribution of U_P, combining with the sea surface height data and geostrophic current field. The results show that water mass U_P exists in all four seasons with the maximum range in spring and the minimum range in summer. In spring and winter, the U_P intrudes into the Luzon Strait and the southwest of Taiwan Island via the northern Luzon Strait in the form of nonlinear Rossby eddies, and forms a high temperature and high salinity zone east of the Dongsha Islands. In summer, the U_P is sporadically distributed in the study area. In autumn, the U_P is located in the upper 200 m layer east of Hainan Island.
文摘Introduction: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South China.Methods: In this retrospective case?based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in Sun Yat?sen University Cancer Center between January 2004 and May 2013 were included. The incidence, risk factors, and survival status of these patients were reviewed and analyzed.Results: Of the 106 patients, 11(10.4%) developed brain metastasis, accounting for 20.0% of 55 patients with relapse or progression. The age at initial diagnosis of the 11 patients ranged from 2 to 10 years(median 4 years), which was younger than that of the patients without brain metastasis(median 5 years, range 1–10 years, P = 0.073). The male to female ratio of the 11 patients was 8:3, which was not signiicantly diferent from that of the patients with?out brain metastasis(P = 0.86). Patients with brain metastasis had higher lactate dehydrogenase levels than those without brain metastasis, but the diferences were not signiicant(P initial diagnosis to the develo= 0.076). Eight patients died, and 3 patients survived. The median interval from thepment of brain metastasis was 18 months(range 6–32 months). The median survival was 4 months(range 1 day to 29 months) after the diagnosis of brain metastasis. The median interval from the manifestation of brain metastasis to death was 3 months(range 1 day to 11 months).Conclusions: High?risk factors for brain metastasis in cases of neuroblastoma include bone marrow involvement and a younger age at initial diagnosis. Nevertheless, multiple treatment modalities can improve disease?free survival.
文摘For children with stage II testicular malignant germ cell tumors(MGCT), the survival is good with surgery and adjuvant chemotherapy. However, there is limited data on surgical results for cases in which there was no imaging or pathologic evidence of residual tumor, but in which serum tumor markers either increased or failed to normalize after an appropriate period of half-life time post-surgery. To determine the use of chemotherapy for children with stage II germ cell tumors, we analyzed the outcomes(relapse rate and overall survival) of patients who were treated at the Sun Yat-sen University Cancer Center between January 1990 and May 2013. Twenty-four pediatric patients with a median age of 20 months(range, 4 months to 17 years) were enrolled in this study. In 20 cases(83.3%), the tumors had yolk sac histology. For definitive treatment, 21 patients underwent surgery alone, and 3 patients received surgery and adjuvant chemotherapy. No relapse was observed in the 3 patients who received adjuvant chemotherapy, whereas relapse occurred in 16 of the 21 patients(76.2%) treated with surgery alone. There were a total of 2 deaths. Treatment was stopped for 1 patient, who died 3 months later due to the tumor. The other patient achieved complete response after salvage treatment, but developed lung and pelvic metastases 7 months later and died of the tumor after stopping treatment. For children treated with surgery alone and surgery combined with adjuvant chemotherapy, the 3-year event-free survival rates were 23.8% and 100%, respectively(P = 0.042), and the 3-year overall survival rates were 90.5% and 100%, respectively(P = 0.588). These results suggest that adjuvant chemotherapy can help to reduce the recurrence rate and increase the survival rate for patients with stage II germ cell tumors.
文摘Primary central nervous system germ cell tumors(CNS-GCTs) in children and adolescents have unique clinical features and methods of treatment compared with those in adults. There is little information about Chinese children and adolescents with CNS-GCTs. Therefore, in this study we retrospectively analyzed the clinical features and treatment outcome of Chinese children and adolescents with primary CNS-GCTs. Between January 2002 and December 2012, 57 untreated patients from a single institution were enrolled. They were diagnosed with CNS-GCTs after pathologic or clinical assessment. Of the 57 patients, 41 were males and 16 were females, with a median age of 12.8 years(range, 2.7 to 18.0 years) at diagnosis; 43(75.4%) had non-germinomatous germ cell tumors(NGGCTs) and 14(24.6%) had germinomas; 44(77.2%) had localized disease and 13(22.8%) had extensive lesions. Fifty-three patients completed the prescribed treatment, of which 18 underwent monotherapy of surgery, radiotherapy, or chemotherapy, and 35 underwent multimodality therapies that included radiotherapy combined with chemotherapy or surgery combined with chemotherapy and/or radiotherapy. PEB(cisplatin, etoposide, and bleomycin) protocol was the major chemotherapy regimen. The median follow-up time was 32.3 months(range, 1.2 to 139 months). Fourteen patients died of relapse or disease progression. The 3-year event-free survival(EFS) and overall survival rates for all patients were 72.2% and 73.8%, respectively. The 3-year EFS was 92.9% for germinomas and 64.8% for NGGCTs(P = 0.064). The 3-year EFS rates for patients with NGGCTs who underwent monotherapy and multimodality therapies were 50.6% and 73.5%, respectively(P = 0.042). Our results indicate that multimodality therapies including chemotherapy plus radiotherapy were better treatment option for children and adolescents with CNS-GCTs.
基金Supported by the Scholarship of China Scholarship Council(CSC)(201606935043)
文摘Directed at the problem of occlusion in target tracking,a new improved algorithm based on the Meanshift algorithm and Kalman filter is proposed.The algorithm effectively combines the Meanshift algorithm with the Kalman filtering algorithm to determine the position of the target centroid and subsequently adjust the current search window adaptively according to the target centroid position and the previous frame search window boundary.The derived search window is more closely matched to the location of the target,which improves the accuracy and reliability of tracking.The environmental influence and other influencing factors on the algorithm are also reduced.Through comparison and analysis of the experiments,the modified algorithm demonstrates good stability and adaptability,and can effectively solve the problem of large area occlusion and similar interference.
基金financially supported by the National Key R&D Program of China(2018YFB1500102,2018YFB2200101)the National Natural Science Foundation of China(61974063,61921005)+3 种基金Natural Science Foundation of Jiangsu Province(BK20190315)the Fundamental Research Funds for the Central Universities(14380168)the Thousand Talent Program for Young Outstanding Scientists in ChinaProgram for Innovative Talents and Entrepreneur in Jiangsu。
文摘The grain surfaces(film surface and grain boundary)of polycrystalline perovskite films are vulnerable sites in solar cells since they pose a high defect density and initiate the degradation of perovskite absorber.Achieving simultaneously defect passivation and grain protection from moisture is crucial for the viability of perovskite solar cells.Here,an in situ cross-linked grain encapsulation(CLGE)strategy that improves both device stability and defect passivation is reported.Cross-linkable semiconducting small molecules are mixed into the antisolvent to uniformly form a compact and conducting cross-linked layer over the grain surfaces.This cross-linked coating layer not only passivates trap states and facilitates hole extraction,but also enhances the device stability by preventing moisture diffusion.Using the CLGE strategy,a high power conversion efficiency(PCE)of 22.7%is obtained in 1.55-eV bandgap planar perovskite solar cells.The unencapsulated devices with CLGE exhibit significantly enhanced device stability again moisture and maintain>90%of their initial PCE after shelf storage under ambient condition for over10,000 h.