A Large-Scale Group Decision Making Model Based on Trust Relationship and Social Network Updating

With the development of big data and social computing,large-scale group decisionmaking(LGDM)is nowmerging with social networks.Using social network analysis(SNA),this study proposes an LGDM consensus model that considers the trust relationship among decisionmakers(DMs).In the process of consensusmeasurement:the social network is constructed according to the social relationship among DMs,and the Louvain method is introduced to classify social networks to form subgroups.In this study,the weights of each decision maker and each subgroup are computed by comprehensive network weights and trust weights.In the process of consensus improvement:A feedback mechanism with four identification and two direction rules is designed to guide the consensus of the improvement process.Based on the trust relationship among DMs,the preferences are modified,and the corresponding social network is updated to accelerate the consensus.Compared with the previous research,the proposedmodel not only allows the subgroups to be reconstructed and updated during the adjustment process,but also improves the accuracy of the adjustment by the feedbackmechanism.Finally,an example analysis is conducted to verify the effectiveness and flexibility of the proposed method.Moreover,compared with previous studies,the superiority of the proposed method in solving the LGDM problem is highlighted.

Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and FGF21.Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also expressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly understood.Here,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in mice.Mechanistically,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col II.Intra-articular injection of r Fap significantly accelerated Col II degradation and OA progression.In contrast,Oln is expressed in the superficial layer of articular cartilage and is significantly downregulated in OA.Genetic deletion of Oln significantly exacerbated OA progression,which was partially rescued by Fap deletion or inhibition.Intra-articular injection of r Oln significantly ameliorated OA progression.Taken together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation.

Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold

Photothermal agents with strong light absorption in the second near-infrared(NIR-II)region(1000-1350 nm)are strongly desired for successful photothermal therapy(PTT).In this work,titania-coated Au nanobipyramids(NBP@TiO2)with a strong plasmon resonance in the NIR-II window were synthesized.The NBP@TiO2 nanostructures have a high photothermal conversion efficiency of(93.3±5.2)%under 1064-nm laser irradiation.They are also capable for loading an anticancer drug combretastatin A-4 phosphate(CA4P).In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P.Moreover,the CA4P-loaded NBP@TiO2 nanostructures combined with PTT induce a synergistic antiangiogenesis effect.In vivo studies show that such CA4Ploaded NBP@TiO2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm?2,which is lower than the skin tolerance threshold value,exhibit a superior antitumor effect.This work presents not only the development of the NBP@TiO2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.

Common traditional Chinese medicine therapies for diarrhea-predominant irritable bowel syndrome: An overview of systematic reviews

Objective: To critically evaluate and summarize the methodological quality of systematic reviews(SRs)and present objective and important outcomes on the effectiveness of traditional Chinese medicine(TCM) therapies, including Chinese herbal medicine(CHM), acupuncture, and moxibustion, for diarrheapredominant irritable bowel syndrome(IBS-D).Methods: We conducted a comprehensive literature search for SRs in 7 databases until April 16, 2022.Two reviewers independently extracted data and assessed the methodological quality of the reviews according to the Assessing the Methodological Quality of Systematic Reviews 2(AMSTAR-2), the Risk of Bias in Systematic reviews(ROBIS) tool, and the Preferred Reporting Item for Systematic Review and Meta-analysis(PRISMA) statement. The Grading of Recommendations, Assessment, Development, and Evaluation(GRADE) was used to rate the quality of evidence.Results: IBS-D patients included in 12 reviews were diagnosed in accordance with the Rome criteria, 9 reviews focused on CHM, 2 articles observed moxibustion and heat-sensitive moxibustion, 1 article studied acupuncture and CHM. The outcomes of the SRs were the effectiveness rate, the total effectiveness rate,global symptom improvement, and adverse effects. Based on AMSTAR-2, which measures the quality of methodology, all of the included studies were of low or critically low quality. According to the ROBIS tool, 10 SRs(83.33%) had a high risk of bias. With the PRISMA checklist, only 3 SRs reached over 90% compliance.Based on GRADE, most evidence was of low quality, and there was a moderate quality of evidence that the effectiveness rate of modified-Tongxie Yaofang was superior to Western medicine in the treatment of IBS-D.Conclusion: Given the suboptimal reporting and methodological quality of existing SRs, more studies are needed to clarify whether TCM therapies are more effective or safe than pharmacological medicine.Future studies should combine evidence-based medicine with TCM research according to the characteristics of TCM.

Effects of Ginsenoside Rb1 Babu Agent on the Amplitude of Microvascular Vasomotion

[Objectives] To study the effects of ginsenoside Rbl Babu agent on the amplitude of microvascular vasomotion. [Methods]The in vitro transdermal permeation of ginsenoside Rbl Babu agent was performed by using intelligent transdermal apparatus,and the percutaneous fluid was collected and analyzed by using high performance liquid chromatography( HPLC). The Babu agent was stuck on the skin of acupoint area,determined by Laser Doppler Flowmeter,and amplitude of microvascular vasomotion of acupoint area was recorded. [Results] With the extension of transdermal time,the cumulative permeation rate of ginsenoside Rbl increased. The amplitude of microvascular vasomotion could be significantly increased with the application of ginsenoside Rbl Babu agent( P < 0. 01). [Conclusions]The drug delivery system of ginsenoside Rbl Babu agent can release the drug into the acupoint,increase the amplitude of microvascular vasomotion,and achieve the effect of acupuncture. Therefore,ginsenoside Rbl Babu agent can replace the acupuncture clinically to treat diseases.

Biomarkers of aging

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

Achieving robust nitritation in a modified continuous-flow reactor: From micro-granule cultivation to nitrite-oxidizing bacteria elimination

In this study,a modified continuous-flow nitrifying reactor was successfully operated for rapid cultivation of micro-granules and achieving robust nitritation.Results showed that sludge granulation with mean size of ca.100μm was achieved within three weeks by gradually increasing settling velocity-based selection pressure from 0.48 to 0.9 m/hr.Though Nitrospira like nitrite-oxidizing bacteria(NOB)were enriched in the micro-granules with a ratio between ammonia-oxidizing bacteria(AOB)and NOB of 5.7%/6.5% on day 21,fast nitritation was achieved within one-week by gradually increasing of influent ammonium concentration(from 50 to 200 mg/L).Maintaining ammonium in-excess was the key for repressing NOB in the micro-granules.Interestingly,when the influent ammonium concentration switched back to 50 mg/L still with the residual ammonium of 15–25 mg/L,the nitrite accumulation efficiency increased from 90%to 98%.Experimental results suggested that the NOB repression was intensified by both oxygen and nitrite unavailability in the inner layers of micro-granules.Unexpectedly,continuous operation with ammonium in excess resulted in overproduction of extracellular polysaccharides and overgrowth of some bacteria(e.g.,Nitrosomonas,Arenimonas,and Flavobacterium),which deteriorated the micro-granule stability and drove the micro-granules aggregation into larger ones with irregular morphology.However,efficient nitritation was stably maintained with extremely high ammonium oxidation potential(>50 mg/g VSS/hr)and nearly complete washout of NOB was obtained.This suggested that smooth and spherical granule was not a prerequisite for achieving NOB wash-out and maintaining effective nitritation in the granular reactor.Overall,the microgranules exhibited a great practical potential for high-rate nitritation.

Highly efficient electrocatalytic nitrogen fixation enabled by the bridging effect of Ru in plasmonic nanoparticles

Plasmon-generated hot electrons show great potential for driving chemical reactions.The utilization efficiency of hot electrons is highly dependent on the interaction of the electronic states at the interfaces between plasmonic nanoparticles and other materials/molecules.Strong interaction can produce new hybridized electron states,which permit direct hot-electron transfer,a more efficient transfer mechanism.However,Au usually has very weak interaction with most molecules because of its inertness,which makes direct hot-electron transfer impossible.Herein,the improvement of the hot-electron transfer efficiency from Au to N_(2)is demonstrated by introducing a Ru bridging layer.Both the N_(2)fixation rate and Faradic efficiency(FE)are enhanced by the excitation of plasmons.The enhancement of the N_(2)fixation rate is found to arise from plasmon-generated hot electrons.Theoretical calculations show that the strong interaction of the Ru electronic states with the N_(2)molecular orbitals produces new hybridized electronic states,and the Ru d electrons also strongly couple with the Au sp electrons.Such a bridging role of Ru makes direct hot-electron transfer from Au to N_(2)possible,improving the FE of nitrogen fixation.Our findings demonstrate a new approach to increasing the utilization efficiency of plasmonic hot electrons for chemical reactions and will be helpful to the design of plasmonic catalysts in the future.

Giant two-photon absorption of anatase TiO_(2) in Au/TiO_(2) core-shell nanoparticles

We report on deep-to-near-UV transient absorption spectra of core-shell Au∕SiO_(2) and Au∕TiO_(2) nanoparticles(NPs) excited at the surface plasmon resonance of the Au core, and of UV-excited bare anatase TiO_(2) NPs. The bleaching of the first excitonic transition of anatase TiO_(2) at ~3.8 e V is a signature of the presence of electrons/holes in the conduction band(CB)/valence band(VB) of the material. We find that while in bare anatase TiO_(2) NPs, two-photon excitation does not occur up to the highest used fluences(1.34 mJ∕cm^(2)), it takes place in the TiO_(2) shell at moderate fluences(0.18 mJ∕cm^(2)) in Au∕TiO_(2) core-shell NPs, as a result of an enhancement due to the plasmon resonance. We estimate the enhancement factor to be of the order of ~10~8–10~9. Remarkably, we observe that the bleach of the 3.8 eV band of TiO_(2) lives significantly longer than in bare TiO_(2), suggesting that the excess electrons/holes in the conduction/valence band are stored longer in this material.

新型冠状病毒肺炎疫情防控期核医学诊疗工作的防护建议

2019年12月以来,新型冠状病毒肺炎(COVID-19)被发现并迅速蔓延。疫情防控期核医学诊疗工作中如何进行防护显得尤为重要。核医学诊疗工作涉及门诊、影像检查、检验和放射性核素病房治疗等,环节较多,流程相对复杂。因此,对核医学诊疗过程中各个环节工作人员和患者的管理、防护以及工作场所的环境消毒等的要求应更为严格。笔者根据国家相关指南和实际工作状况,提出了COVID-19疫情防控期核医学诊疗工作的防护建议,旨在加强核医学诊疗工作中的防控,并保障医患安全。

Mechanism on minimization of excess sludge in oxic-settling- anaerobic (OSA) process

The oxic-settling-anaerobic(OSA)process is a promising wastewater treatment technique for efficiently reducing sludge production and improving the stability of process operation.In this paper,the possible factors of sludge reduction such as sludge decay,uncoupled metabol-ism,and anaerobic oxidation with low sludge production were discussed in the OSA process.It has been confirmed that sludge decay is the decisive cause in the OSA process,accounting for 66.7%of sludge production reduction.Sludge decay includes hydrolysis and acidogenesis of dead microorganisms and particle organic carbon adsorbed in sludge floc and endogenous metabolism.By batch experi-ments,it has been proven that there is energetic uncoupling in the OSA system since microorganisms were exposed to alternative anaerobic and aerobic environment.It accounts for about 7.5%of sludge production reduction.Soluble chemical oxygen demand(SCOD)released from the anaerobic sludge tank in the OSA process was used as the substrate for cryptic growth.The substrate was used for anoxic denitrifying,anaerobic phosphorus release,sulfate reduction,and methane production.These anaerobic reactions in the sludge anaerobic tank have lower sludge production than in the aerobic oxidation when equivalent SCOD is consumed,which may lead to approximately 23%of sludge reduction in the OSA process.It has been concluded that multiple causes resulted in the minimization of excess sludge in the OSA system.The microbial community structure and diversity of sludge samples from the CAS(conventional activated sludge)and OSA systems were investigated by 16 SrDNA PCR-DG-DGGE(poly-merase chain reaction-double gradient-denaturing gradient gel electrophoresis).DGGE profile and cluster analysis showed more abundant species in the OSA system contrasting to microbial communities in the CAS system.

Pd films on soft substrates:a visual,high-contrast and low-cost optical hydrogen sensor

For the rapid development of the hydrogen economy,a reliable and low-cost hydrogen sensor appears to be extremely important.Here,we first show that a palladium film deposited on polydimethylsiloxane(PDMS)can obtain an exceedingly high-reflectance contrast of 25.78 over the entire visible band upon exposure to 4 vol% hydrogen gas(H2)mixed with nitrogen gas.This high-reflectance contrast results from the surface deformation induced by the volume inflation after exposure to H2,leading to the transition of the near-specular surface to a diffusing surface.In addition,a change in brightness is readable by naked eye upon exposure to H2 with various concentrations from 0.6 to 1 vol% under the illumination of a fluorescent tube.Furthermore,this sensor possesses an excellent recyclability and quick response time of a few seconds.Compared with Pd nanostructure-based hydrogen sensors,this visual,high-contrast and low-cost sensor is of great potential for practical hydrogen sensing.

(Metal yolk)/(porous ceria shell)nanostructures for high-performance plasmonic photocatalysis under visible light

We describe a route to the preparation of(metal yolk)/(porous ceria shell)nanostructures through the heterogeneous growth of ceria on porous metal nanoparticles followed by the calcination-induced shrinkage of the nanoparticles.The approach allows for the control of the ceria shell thickness,the metal yolk composition and size,which is difficult to realize through common templating approaches.The yolk/shell nanostructures with monometallic Pt and bimetallic PtAg yolks featuring plasmon-induced broadband light absorption in the visible region are rationally designed and constructed.The superior photocatalytic activities of the obtained nanostructures are demonstrated by the selective oxidation of benzyl alcohol under visible light.The excellent activities are ascribed to the synergistic effects of the metal yolk and the ceria shell on the light absorption,electron-hole separation and efficient mass transfer.Our synthesis of the(metal yolk)/(porous ceria shell)nanostructures points out a way to the creation of sophisticated heteronanostructures for high-performance photocatalysis.

Edge-face chromatic number of Halin-graphs

Definition 1. Assume that G（V, E, F）is a 3-connected plane graph. Remove all edges on the boundary of a face f0 whose degree of all vertices of $ V（f-0）$ is 3 such that G becomes a tree T whose degree of all vertices except those of V（f0） is at least 3. Then G is called a Halin-graph, f0

Colour routing with single silver nanorods

Elongated plasmonic nanoparticles have been extensively explored over the past two decades.However,in comparison with the dipolar plasmon mode that has attracted the most interest,much less attention has been paid to multipolar plasmon modes because they are usually thought to be“dark modes”,which are unable to interact with farfield light efficiently.Herein,we report on an intriguing far-field scattering phenomenon,colour routing,based on longitudinal multipolar plasmon modes supported by high-aspect-ratio single Ag nanorods.Taking advantage of the distinct far-field behaviours of the odd and even multipolar plasmon modes,we demonstrate two types of colour routing,where the incident white light can be scattered into several beams with different colours as well as different propagation directions.Because of the narrow linewidths of the longitudinal multipolar plasmon modes,there is little spectral overlap between the adjacent peaks,giving rise to outstanding colour selectivity.Our experimental results and theoretical model provide a simple yet effective picture for understanding the far-field behaviour of the longitudinal multipolar plasmon modes and the resultant colour routing phenomenon.Moreover,the outstanding colour routing capability of the high-aspect-ratio Ag nanorods enables nanoscale optical components with simple geometries for controlling the propagation of light below the diffraction limit of light.

Chirality-selective transparency induced by lattice resonance in bilayer metasurfaces

Chiral optical responses of bilayer metasurfaces made of twisted metallic nanorods are investigated in detail with focus on the collective effect due to lattice resonance(LR).Using an analytical approach based on the coupled dipole method(supported by full wave simulation),we find optical chirality is dramatically increased by the coupling between localized surface plasmon resonances and LR.The collective effect results in significant chiral signal even for metasurfaces made of achiral unit cells.The interlayer coupling generally destroys the Wood’s anomaly and the associated transparency.While making use of Pancharatnam–Berry(PB)phase and propagation phase,one can modulate the optical activity effectively and achieve chirality-selective transparency induced by LR in a designed structure with a g-factor of absorption as high as 1.99(close to the upper limit of 2).Our studies not only reveal a new mechanism of modulating chiral optical response by combination effects from PB phase,propagation phase,and LR,but also give a quantitative relationship between the geometry configuration and chiral optical properties,thus providing helpful guidance for device design.