目的系统评价顺铂与卡铂对比治疗晚期三阴性乳腺癌(TNBC)的疗效及安全性。方法检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普、万方、Clinical Trials、PubMed、EmBase、Ovid、Web of Science、Scopus及Cochrane Library数据...目的系统评价顺铂与卡铂对比治疗晚期三阴性乳腺癌(TNBC)的疗效及安全性。方法检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普、万方、Clinical Trials、PubMed、EmBase、Ovid、Web of Science、Scopus及Cochrane Library数据库,搜集关于顺铂对比卡铂治疗晚期TNBC疗效及安全性的随机对照试验(RCT),检索时间为自建库至2021年12月,提取数据后采用RevMan5.4统计软件进行Meta分析。结果最终纳入9项RCT,共632例晚期TNBC患者。结果显示,顺铂组与卡铂组在客观缓解率(ORR)、2年生存率方面差异无统计学意义(OR=1.12,95%CI:0.80~1.57,P=0.49;OR=1.22,95%CI:0.60~2.48,P=0.59);不良反应(ADR)分析显示,试验组恶心、呕吐发生率高于对照组,差异有统计学意义(OR=2.56,95%CI:1.56~4.20,P<0.05),试验组中性粒细胞减少、血小板减少发生率低于对照组,差异有统计学意义(OR=0.46,95%CI:0.27~0.79,P<0.05;OR=0.27,95%CI:0.16~0.47,P<0.05);试验组与对照组在肾毒性、白细胞减少、贫血方面差异无统计学意义(OR=1.46,95%CI:0.22~9.47,P=0.69;OR=0.86,95%CI:0.28~2.60,P=0.78;OR=0.94,95%CI:0.35~2.51,P=0.91)。结论顺铂与卡铂治疗晚期TNBC疾病的ORR相似,2年生存率对比无明显差异,而顺铂消化道反应发生率较高,卡铂血液毒性反应发生率较高。展开更多
The tribological properties of isostatic graphite and carbon graphite under dry sliding and water lubricated conditions were studied.The friction test was conducted by using a pin-on-disc tribometer.The friction coeff...The tribological properties of isostatic graphite and carbon graphite under dry sliding and water lubricated conditions were studied.The friction test was conducted by using a pin-on-disc tribometer.The friction coefficient and the wear rate were employed to evaluate the tribological performances of the two materials,and wear morphology was used to analyze the wear mechanism.The results show that the friction coefficient of the isostatic graphite is larger than that of the carbon graphite under the dry sliding condition,and the wear rate is lower than that of the carbon graphite.Under the water lubricated condition,the friction coefficients and the wear rates of the isostatic graphite decrease obviously.The main wear form of the isostatic graphite is abrasive wear,while the main wear form of the carbon graphite is spalling wear.Finally,the tribological mechanism of the isostatic graphite under dry sliding and water lubricated conditions were systematically analyzed.展开更多
In current research about nanofluid convection heat transfer, random motion of nanoparticles in the liquid distribution problem mostly was not considered. In order to study on the distribution of nanoparticles in liqu...In current research about nanofluid convection heat transfer, random motion of nanoparticles in the liquid distribution problem mostly was not considered. In order to study on the distribution of nanoparticles in liquid, nanofluid transport model in pipe is established by using the continuity equation, momentum equation and Fokker-Planck equation. The velocity distribution and the nanoparticles distribution in liquid are obtained by numerical calculation, and the effect of particle size and particle volume fraction on convection heat transfer coefficient of nanofluids is analyzed. The result shows that in high volume fraction （ 0 _-- 0.8% ）, the velocity distribution of nanofluids characterizes as a ＂cork-shaped＂ structure, which is significantly different from viscous fluid with a parabolic distribution. The convection heat transfer coefficient increases while the particle size of nanoparticle in nanofluids decreases. And the convection heat transfer coefficient of nanofluids is in good agreement with the experimental result both in low （0 ~〈 0.1% ） and high （ q = 0.6% ） volume fractions. In presented model, Brown motion, the effect of interactions between nanoparticles and fluid coupling, is also considered, but any phenomenological parameter is not introduced. Nanoparticles in liquid transport distribution can be quantitatively calculated by this model.展开更多
Isostatic graphite materials with 8%porosity and 14%porosity were prepared by the cold isostatic pressing process.Cavitation erosion resistance of the isostatic graphite was evaluated through cavitation tests in an ul...Isostatic graphite materials with 8%porosity and 14%porosity were prepared by the cold isostatic pressing process.Cavitation erosion resistance of the isostatic graphite was evaluated through cavitation tests in an ultrasonic vibration system.The volume loss and erosion morphology of the isostatic graphite were adopted to investigate the cavitation erosion resistance of the isostatic graphite.The cavitation test results show that after ultrasonic vibration of 14 h,the volume loss of the isostatic graphite materials with 8%porosity and 14%porosity are 35%and 46%of the carbon graphite material,respectively.The isostatic graphite material with 8%porosity exhibits an outstanding capability to resist cavitation erosion damage,and the cavitation erosion resistance of the isostatic graphite enhances with the decrease in porosity.The damage mechanism of isostatic graphite is brittle fracture attributed to the shock wave and micro jet.The isostatic graphite with low porosity exhibits excellent cavitation erosion resistance due to its fine graphite particles,homogeneous structure and high degree of hardness.展开更多
文摘目的系统评价顺铂与卡铂对比治疗晚期三阴性乳腺癌(TNBC)的疗效及安全性。方法检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普、万方、Clinical Trials、PubMed、EmBase、Ovid、Web of Science、Scopus及Cochrane Library数据库,搜集关于顺铂对比卡铂治疗晚期TNBC疗效及安全性的随机对照试验(RCT),检索时间为自建库至2021年12月,提取数据后采用RevMan5.4统计软件进行Meta分析。结果最终纳入9项RCT,共632例晚期TNBC患者。结果显示,顺铂组与卡铂组在客观缓解率(ORR)、2年生存率方面差异无统计学意义(OR=1.12,95%CI:0.80~1.57,P=0.49;OR=1.22,95%CI:0.60~2.48,P=0.59);不良反应(ADR)分析显示,试验组恶心、呕吐发生率高于对照组,差异有统计学意义(OR=2.56,95%CI:1.56~4.20,P<0.05),试验组中性粒细胞减少、血小板减少发生率低于对照组,差异有统计学意义(OR=0.46,95%CI:0.27~0.79,P<0.05;OR=0.27,95%CI:0.16~0.47,P<0.05);试验组与对照组在肾毒性、白细胞减少、贫血方面差异无统计学意义(OR=1.46,95%CI:0.22~9.47,P=0.69;OR=0.86,95%CI:0.28~2.60,P=0.78;OR=0.94,95%CI:0.35~2.51,P=0.91)。结论顺铂与卡铂治疗晚期TNBC疾病的ORR相似,2年生存率对比无明显差异,而顺铂消化道反应发生率较高,卡铂血液毒性反应发生率较高。
文摘目的探讨R-spondin3(RSPO3)在乳腺癌中的表达及预后价值。方法应用TIMER、癌症基因组图谱(The Cancer Genome Atlas,TCGA)、基因表达谱数据动态分析(gene expression profilling in-teractive analysis 2,GEPIA2)、人类蛋白质表达图谱(Human Protein Atlas,HPA)等数据库分析RSPO3在乳腺癌组织和癌周正常组织中的差异表达,并分析其表达水平与乳腺癌病理学参数之间的相关性;GEPIA2数据库探讨RSPO3转录本在乳腺癌中的表达及其结构特征;Kaplan-Meier Plotter绘制RSPO3与乳腺癌患者的预后生存曲线;运用基因本体论(gene ontology,GO)和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)等对其进行基因功能富集分析和代谢通路分析;应用TIMER数据库分析RSPO3的表达水平与肿瘤微环境中免疫细胞浸润的相关性。结果RSPO3在乳腺癌中呈低表达,且其表达水平与乳腺癌患者的年龄、肿瘤最大径、分子分型相关,在乳腺癌中低表达的RSPO3与患者的预后不良相关;GO功能富集分析显示,RSPO3相互作用的基因主要富集于免疫细胞及其受体等参与的生物学过程;免疫细胞浸润分析结果显示,RSPO3在乳腺癌组织中的表达水平与CD8^(+)T细胞、CD4^(+)T细胞、CD4^(+)记忆T细胞、巨噬细胞、B细胞等的浸润水平呈正相关,而与调节性T细胞(Treg细胞)的浸润水平呈负相关;KEGG代谢通路分析显示,RSPO3可能参与Wnt/β-catenin通路。结论在乳腺癌中低表达的RSPO3与患者的不良预后相关,其可能通过抑制免疫细胞浸润及活化Wnt/β-catenin通路参与乳腺癌的进展。
基金The National Natural Science Foundation of China(No.51635004,11472078)。
文摘The tribological properties of isostatic graphite and carbon graphite under dry sliding and water lubricated conditions were studied.The friction test was conducted by using a pin-on-disc tribometer.The friction coefficient and the wear rate were employed to evaluate the tribological performances of the two materials,and wear morphology was used to analyze the wear mechanism.The results show that the friction coefficient of the isostatic graphite is larger than that of the carbon graphite under the dry sliding condition,and the wear rate is lower than that of the carbon graphite.Under the water lubricated condition,the friction coefficients and the wear rates of the isostatic graphite decrease obviously.The main wear form of the isostatic graphite is abrasive wear,while the main wear form of the carbon graphite is spalling wear.Finally,the tribological mechanism of the isostatic graphite under dry sliding and water lubricated conditions were systematically analyzed.
基金supported by National Natural Science Foundation of China(Grant No.51375090)
文摘In current research about nanofluid convection heat transfer, random motion of nanoparticles in the liquid distribution problem mostly was not considered. In order to study on the distribution of nanoparticles in liquid, nanofluid transport model in pipe is established by using the continuity equation, momentum equation and Fokker-Planck equation. The velocity distribution and the nanoparticles distribution in liquid are obtained by numerical calculation, and the effect of particle size and particle volume fraction on convection heat transfer coefficient of nanofluids is analyzed. The result shows that in high volume fraction （ 0 _-- 0.8% ）, the velocity distribution of nanofluids characterizes as a ＂cork-shaped＂ structure, which is significantly different from viscous fluid with a parabolic distribution. The convection heat transfer coefficient increases while the particle size of nanoparticle in nanofluids decreases. And the convection heat transfer coefficient of nanofluids is in good agreement with the experimental result both in low （0 ~〈 0.1% ） and high （ q = 0.6% ） volume fractions. In presented model, Brown motion, the effect of interactions between nanoparticles and fluid coupling, is also considered, but any phenomenological parameter is not introduced. Nanoparticles in liquid transport distribution can be quantitatively calculated by this model.
基金The National Natural Science Foundation of China(No.51635004,11472078)。
文摘Isostatic graphite materials with 8%porosity and 14%porosity were prepared by the cold isostatic pressing process.Cavitation erosion resistance of the isostatic graphite was evaluated through cavitation tests in an ultrasonic vibration system.The volume loss and erosion morphology of the isostatic graphite were adopted to investigate the cavitation erosion resistance of the isostatic graphite.The cavitation test results show that after ultrasonic vibration of 14 h,the volume loss of the isostatic graphite materials with 8%porosity and 14%porosity are 35%and 46%of the carbon graphite material,respectively.The isostatic graphite material with 8%porosity exhibits an outstanding capability to resist cavitation erosion damage,and the cavitation erosion resistance of the isostatic graphite enhances with the decrease in porosity.The damage mechanism of isostatic graphite is brittle fracture attributed to the shock wave and micro jet.The isostatic graphite with low porosity exhibits excellent cavitation erosion resistance due to its fine graphite particles,homogeneous structure and high degree of hardness.
