In recent years, target tracking has been considered one of the most important applications of wireless sensornetwork (WSN). Optimizing target tracking performance and prolonging network lifetime are two equally criti...In recent years, target tracking has been considered one of the most important applications of wireless sensornetwork (WSN). Optimizing target tracking performance and prolonging network lifetime are two equally criticalobjectives in this scenario. The existing mechanisms still have weaknesses in balancing the two demands. Theproposed heuristic multi-node collaborative scheduling mechanism (HMNCS) comprises cluster head (CH)election, pre-selection, and task set selectionmechanisms, where the latter two kinds of selections forma two-layerselection mechanism. The CH election innovatively introduces the movement trend of the target and establishesa scoring mechanism to determine the optimal CH, which can delay the CH rotation and thus reduce energyconsumption. The pre-selection mechanism adaptively filters out suitable nodes as the candidate task set to applyfor tracking tasks, which can reduce the application consumption and the overhead of the following task setselection. Finally, the task node selection is mathematically transformed into an optimization problem and thegenetic algorithm is adopted to form a final task set in the task set selection mechanism. Simulation results showthat HMNCS outperforms other compared mechanisms in the tracking accuracy and the network lifetime.展开更多
The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal properties.However,the mechanisms underlying betulin biosynthesis responding to climate change remain unc...The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal properties.However,the mechanisms underlying betulin biosynthesis responding to climate change remain unclear.In this study,the role of epigenetic modification(DNA methylation) in betulin biosynthesis was examined and how climatic factors influence it.Whole-genome bisulfite sequencing was performed for greenhouse-grown Chinese white birch(Betula platyphylla Sukaczev) treated with DNA methylation inhibitor zebularine(ZEB) and a natural birch population in Northeast China.ZEB treatment significantly affected the CHH methylation level of transposable elements and betulin content in a hormesis dose-dependent manner.The methylation and expression of bHLH9,a key transcriptional factor controlling betulin biosynthesis,were also consistently affected by ZEB treatment as a hormetic dose-response.In the natural population,there was a positive correlation between promoter methylation of bHLH9 and summer precipitation,while winter temperature was negatively correlated.Thus climate-dependent methylation of bHLH9 regulates the expression of downstream genes involved in betulin biosynthesis.This study highlights the role of environmental signals to induce epigenetic changes that result in betulin production,possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production.展开更多
It has been demonstrated that heat absorption method by using the inorganic material rod to cool the molten steel can significantly reduce the macrosegregation level of the large steel ingot.However,owing to the opaci...It has been demonstrated that heat absorption method by using the inorganic material rod to cool the molten steel can significantly reduce the macrosegregation level of the large steel ingot.However,owing to the opacity of the molten steel,the physical mechanism of the heat absorption method is not clear.In this work,a transparent hydraulic physical model with water and paraffin wax was built to simulate the melting and floating processes of inorganic materials in the molten steel.A mathematical simulation was also carried out to analyze the connection between the actual ingot and the physical model.Results show that it is feasible to simulate the molten steel and inorganic materials with water and paraffin wax.With the help of the physical model,the process of the melting of paraffin wax and its floating to the surface of water were clearly observed,during which the temperature of water at some characteristic positions in the mold was recorded.The visualization findings demonstrate that the melting and floating processes of paraffin wax can help to bring the heat from the center of the mold to the top surface more quickly,which reduces the superheat and significantly accelerates the cooling rate of water.The experimental results show that for the water with a certain superheat,the use of a larger mass of paraffin wax can accelerate the cooling of the water,but there is a risk of incomplete melting of the paraffin wax.A higher superheat of water will lead to a quicker melting rate for a given mass of paraffin wax,while a lower superheat leads to the incomplete melting of paraffin wax as well.展开更多
Sodium-ion hybrid capacitor(SIHC)is one of the most promising alternatives for large-scale energy storage due to its high energy and power densities,natural abundance,and low cost.However,overcoming the imbalance betw...Sodium-ion hybrid capacitor(SIHC)is one of the most promising alternatives for large-scale energy storage due to its high energy and power densities,natural abundance,and low cost.However,overcoming the imbalance between slow Na^(+)reaction kinetics of battery-type anodes and rapid ion adsorption/desorption of capacitive cathodes is a significant challenge.Here,we propose the high-rate-performance NiS_(2)@OMGC anode material composed of monodispersed NiS_(2) nanocrystals(8.8±1.7 nm in size)and N,S-co-doped graphenic carbon(GC).The NiS_(2)@OMGC material has a three-dimensionally ordered macroporous(3DOM)morphology,and numerous NiS_(2) nanocrystals are uniformly embedded in GC,forming a core-shell structure in the local area.Ultrafine NiS_(2) nanocrystals and their nano-microstructure demonstrate high pseudocapacitive Na-storage capability and thus excellent rate performance(355.7 mAh/g at 20.0 A/g).A SIHC device fabricated using NiS_(2)@OMGC and commercial activated carbon(AC)cathode exhibits ultrahigh energy densities(197.4 Wh/kg at 398.8 W/kg)and power densities(43.9 kW/kg at 41.3 Wh/kg),together with a long life span.This outcome exemplifies the rational architecture and composition design of this type of anode material.This strategy can be extended to the design and synthesis of a wide range of high-performance electrode materials for energy storage applications.展开更多
The statistics of the number of rapeseed seedlings are very important for breeders and planters to conduct seed quality testing,field crop management and yield estimation.Calculating the number of seedlings is ineffic...The statistics of the number of rapeseed seedlings are very important for breeders and planters to conduct seed quality testing,field crop management and yield estimation.Calculating the number of seedlings is inefficient and cumbersome in the traditional method.In this study,a method was proposed for efficient detection and calculation of rapeseed seedling number based on improved you only look once version 5(YOLOv5)to identify objects and deep-sort to perform object tracking for rapeseed seedling video.Coordinated attention(CA)mechanism was added to the trunk of the improved YOLOv5s,which made the model more effective in identifying shaded,dense and small rapeseed seedlings.Also,the use of the GSConv module replaced the standard convolution at the neck,reduced model parameters and enabled it better able to be equipped for mobile devices.The accuracy and recall rate of using improved YOLOv5s on the test set by 1.9%and 3.7%compared to 96.2%and 93.7%of YOLOv5s,respectively.The experimental results showed that the average error of monitoring the number of seedlings by unmanned aerial vehicles(UAV)video of rapeseed seedlings based on improved YOLOv5s combined with depth-sort method was 4.3%.The presented approach can realize rapid statistics of the number of rapeseed seedlings in the field based on UAV remote sensing,provide a reference for variety selection and precise management of rapeseed.展开更多
Distribution networks denote important public infrastructure necessary for people’s livelihoods.However,extreme natural disasters,such as earthquakes,typhoons,and mudslides,severely threaten the safe and stable opera...Distribution networks denote important public infrastructure necessary for people’s livelihoods.However,extreme natural disasters,such as earthquakes,typhoons,and mudslides,severely threaten the safe and stable operation of distribution networks and power supplies needed for daily life.Therefore,considering the requirements for distribution network disaster prevention and mitigation,there is an urgent need for in-depth research on risk assessment methods of distribution networks under extreme natural disaster conditions.This paper accessesmultisource data,presents the data quality improvement methods of distribution networks,and conducts data-driven active fault diagnosis and disaster damage analysis and evaluation using data-driven theory.Furthermore,the paper realizes real-time,accurate access to distribution network disaster information.The proposed approach performs an accurate and rapid assessment of cross-sectional risk through case study.The minimal average annual outage time can be reduced to 3 h/a in the ring network through case study.The approach proposed in this paper can provide technical support to the further improvement of the ability of distribution networks to cope with extreme natural disasters.展开更多
Hepatocellular carcinoma(HCC)is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths.The progression and metastasis of HCC are closely associated with altered mitochondrial m...Hepatocellular carcinoma(HCC)is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths.The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism,including mitochondrial stress response.Mitokines,soluble proteins produced and secreted in response to mitochondrial stress,play an essential immunomodulatory role.Immunotherapy has emerged as a crucial treatment option for HCC.However,a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment.Therefore,exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy.This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function.In addition,a systematic review of mitokines-mediated immunomodulation in HCC is presented.Finally,the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized.Recent progress in mitokine research represents a new prospect for mitochondrial therapy.Considering the potential of mitokines to regulate immune function,investigating them as a relevant mole cular target holds great promise for the diagnosis and treatment of HCC.展开更多
Developing novel cancer therapies that exploit programmed cell death pathways holds promise for advancing cancer treatment.According to a recently published study in Science,copper death(cuproptosis)occurs when intrac...Developing novel cancer therapies that exploit programmed cell death pathways holds promise for advancing cancer treatment.According to a recently published study in Science,copper death(cuproptosis)occurs when intracellular copper is overloaded,triggering aggregation of lipidated mitochondrial proteins and Fe–S cluster proteins.This intriguing phenomenon is triggered by the instability of copper ions.Understanding the molecular mechanisms behind cuproptosis and its associated genes,as identified by Tsvetkov,including ferredoxin 1,lipoic acid synthase,lipoyltransferase 1,dihydrolipid amide dehydrogenase,dihydrolipoamide transacetylase,pyruvate dehydrogenaseα1,pyruvate dehydrogenaseβ,metallothionein,glutaminase,and cyclin-dependent kinase inhibitor 2A,may open new avenues for cancer therapy.Here,we provide a new understanding of the role of copper death and related genes in cancer.展开更多
基金the Project Program of Science and Technology on Micro-System Laboratory,No.6142804220101.
文摘In recent years, target tracking has been considered one of the most important applications of wireless sensornetwork (WSN). Optimizing target tracking performance and prolonging network lifetime are two equally criticalobjectives in this scenario. The existing mechanisms still have weaknesses in balancing the two demands. Theproposed heuristic multi-node collaborative scheduling mechanism (HMNCS) comprises cluster head (CH)election, pre-selection, and task set selectionmechanisms, where the latter two kinds of selections forma two-layerselection mechanism. The CH election innovatively introduces the movement trend of the target and establishesa scoring mechanism to determine the optimal CH, which can delay the CH rotation and thus reduce energyconsumption. The pre-selection mechanism adaptively filters out suitable nodes as the candidate task set to applyfor tracking tasks, which can reduce the application consumption and the overhead of the following task setselection. Finally, the task node selection is mathematically transformed into an optimization problem and thegenetic algorithm is adopted to form a final task set in the task set selection mechanism. Simulation results showthat HMNCS outperforms other compared mechanisms in the tracking accuracy and the network lifetime.
基金the National Non-profi t Institute Research Grant of the Chinese Academy of Forestry(CAFYBB2019ZY003)the National Natural Science Foundation of China(31871220 and 31801444)+2 种基金the Innovation Project of State Key Laboratory of Tree Genetics andBreeding(Northeast Forestry University)(2013A06)the Fundamental Research Funds for the Central Universities(2572017DA06 and 2572020DP01)Heilongjiang Provincial Natural Science Foundation of China(LH2021C005).
文摘The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal properties.However,the mechanisms underlying betulin biosynthesis responding to climate change remain unclear.In this study,the role of epigenetic modification(DNA methylation) in betulin biosynthesis was examined and how climatic factors influence it.Whole-genome bisulfite sequencing was performed for greenhouse-grown Chinese white birch(Betula platyphylla Sukaczev) treated with DNA methylation inhibitor zebularine(ZEB) and a natural birch population in Northeast China.ZEB treatment significantly affected the CHH methylation level of transposable elements and betulin content in a hormesis dose-dependent manner.The methylation and expression of bHLH9,a key transcriptional factor controlling betulin biosynthesis,were also consistently affected by ZEB treatment as a hormetic dose-response.In the natural population,there was a positive correlation between promoter methylation of bHLH9 and summer precipitation,while winter temperature was negatively correlated.Thus climate-dependent methylation of bHLH9 regulates the expression of downstream genes involved in betulin biosynthesis.This study highlights the role of environmental signals to induce epigenetic changes that result in betulin production,possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production.
基金supported by the National Key Research and Development Program of China(No.2019YFA0705300)Shanghai Rising-Star Program,China(Nos.20QA1403800,21QC1401500)Shanghai Science and Technology Committee,China(Nos.21511103600,20511107700,19DZ1100704)。
基金supported by Shanghai Post-doctoral Excellence Program of China(No.2021166)Shanghai Rising-Star Program(Nos.20QA1403800 and 21QC1401500)Shanghai Science and Technology Committee(No.21511103600).
文摘It has been demonstrated that heat absorption method by using the inorganic material rod to cool the molten steel can significantly reduce the macrosegregation level of the large steel ingot.However,owing to the opacity of the molten steel,the physical mechanism of the heat absorption method is not clear.In this work,a transparent hydraulic physical model with water and paraffin wax was built to simulate the melting and floating processes of inorganic materials in the molten steel.A mathematical simulation was also carried out to analyze the connection between the actual ingot and the physical model.Results show that it is feasible to simulate the molten steel and inorganic materials with water and paraffin wax.With the help of the physical model,the process of the melting of paraffin wax and its floating to the surface of water were clearly observed,during which the temperature of water at some characteristic positions in the mold was recorded.The visualization findings demonstrate that the melting and floating processes of paraffin wax can help to bring the heat from the center of the mold to the top surface more quickly,which reduces the superheat and significantly accelerates the cooling rate of water.The experimental results show that for the water with a certain superheat,the use of a larger mass of paraffin wax can accelerate the cooling of the water,but there is a risk of incomplete melting of the paraffin wax.A higher superheat of water will lead to a quicker melting rate for a given mass of paraffin wax,while a lower superheat leads to the incomplete melting of paraffin wax as well.
基金supported by the National Natural Science Foundation of Tianjin(No.20JCQNJC01280)the National Natural Science Foundation of China(No.21905201)+1 种基金the support of the scientifi c research project from China Three Gorges Corporation(No.202103406)supported by Tohoku University and JSPS KAKENHI(No.JP16J06828).
文摘Sodium-ion hybrid capacitor(SIHC)is one of the most promising alternatives for large-scale energy storage due to its high energy and power densities,natural abundance,and low cost.However,overcoming the imbalance between slow Na^(+)reaction kinetics of battery-type anodes and rapid ion adsorption/desorption of capacitive cathodes is a significant challenge.Here,we propose the high-rate-performance NiS_(2)@OMGC anode material composed of monodispersed NiS_(2) nanocrystals(8.8±1.7 nm in size)and N,S-co-doped graphenic carbon(GC).The NiS_(2)@OMGC material has a three-dimensionally ordered macroporous(3DOM)morphology,and numerous NiS_(2) nanocrystals are uniformly embedded in GC,forming a core-shell structure in the local area.Ultrafine NiS_(2) nanocrystals and their nano-microstructure demonstrate high pseudocapacitive Na-storage capability and thus excellent rate performance(355.7 mAh/g at 20.0 A/g).A SIHC device fabricated using NiS_(2)@OMGC and commercial activated carbon(AC)cathode exhibits ultrahigh energy densities(197.4 Wh/kg at 398.8 W/kg)and power densities(43.9 kW/kg at 41.3 Wh/kg),together with a long life span.This outcome exemplifies the rational architecture and composition design of this type of anode material.This strategy can be extended to the design and synthesis of a wide range of high-performance electrode materials for energy storage applications.
文摘The statistics of the number of rapeseed seedlings are very important for breeders and planters to conduct seed quality testing,field crop management and yield estimation.Calculating the number of seedlings is inefficient and cumbersome in the traditional method.In this study,a method was proposed for efficient detection and calculation of rapeseed seedling number based on improved you only look once version 5(YOLOv5)to identify objects and deep-sort to perform object tracking for rapeseed seedling video.Coordinated attention(CA)mechanism was added to the trunk of the improved YOLOv5s,which made the model more effective in identifying shaded,dense and small rapeseed seedlings.Also,the use of the GSConv module replaced the standard convolution at the neck,reduced model parameters and enabled it better able to be equipped for mobile devices.The accuracy and recall rate of using improved YOLOv5s on the test set by 1.9%and 3.7%compared to 96.2%and 93.7%of YOLOv5s,respectively.The experimental results showed that the average error of monitoring the number of seedlings by unmanned aerial vehicles(UAV)video of rapeseed seedlings based on improved YOLOv5s combined with depth-sort method was 4.3%.The presented approach can realize rapid statistics of the number of rapeseed seedlings in the field based on UAV remote sensing,provide a reference for variety selection and precise management of rapeseed.
文摘Distribution networks denote important public infrastructure necessary for people’s livelihoods.However,extreme natural disasters,such as earthquakes,typhoons,and mudslides,severely threaten the safe and stable operation of distribution networks and power supplies needed for daily life.Therefore,considering the requirements for distribution network disaster prevention and mitigation,there is an urgent need for in-depth research on risk assessment methods of distribution networks under extreme natural disaster conditions.This paper accessesmultisource data,presents the data quality improvement methods of distribution networks,and conducts data-driven active fault diagnosis and disaster damage analysis and evaluation using data-driven theory.Furthermore,the paper realizes real-time,accurate access to distribution network disaster information.The proposed approach performs an accurate and rapid assessment of cross-sectional risk through case study.The minimal average annual outage time can be reduced to 3 h/a in the ring network through case study.The approach proposed in this paper can provide technical support to the further improvement of the ability of distribution networks to cope with extreme natural disasters.
文摘Hepatocellular carcinoma(HCC)is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths.The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism,including mitochondrial stress response.Mitokines,soluble proteins produced and secreted in response to mitochondrial stress,play an essential immunomodulatory role.Immunotherapy has emerged as a crucial treatment option for HCC.However,a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment.Therefore,exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy.This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function.In addition,a systematic review of mitokines-mediated immunomodulation in HCC is presented.Finally,the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized.Recent progress in mitokine research represents a new prospect for mitochondrial therapy.Considering the potential of mitokines to regulate immune function,investigating them as a relevant mole cular target holds great promise for the diagnosis and treatment of HCC.
基金Supported by Scientific Research Project of Hunan Education Department,No.21A0054.
文摘Developing novel cancer therapies that exploit programmed cell death pathways holds promise for advancing cancer treatment.According to a recently published study in Science,copper death(cuproptosis)occurs when intracellular copper is overloaded,triggering aggregation of lipidated mitochondrial proteins and Fe–S cluster proteins.This intriguing phenomenon is triggered by the instability of copper ions.Understanding the molecular mechanisms behind cuproptosis and its associated genes,as identified by Tsvetkov,including ferredoxin 1,lipoic acid synthase,lipoyltransferase 1,dihydrolipid amide dehydrogenase,dihydrolipoamide transacetylase,pyruvate dehydrogenaseα1,pyruvate dehydrogenaseβ,metallothionein,glutaminase,and cyclin-dependent kinase inhibitor 2A,may open new avenues for cancer therapy.Here,we provide a new understanding of the role of copper death and related genes in cancer.
