雌激素预处理在拮抗剂方案中的作用-Meta分析

目的:评价拮抗剂方案中不同卵巢反应患者雌激素预处理的效果。方法:检索数据库(PubMed、Web of Science、中国知网、万方数据库)中关于雌激素预处理在拮抗剂方案中作用的研究进行meta分析。结果:纳入7篇随机临床对照研究、2篇回顾性研究。为了进一步探索异质性的来源,采用亚组分析,主要根据研究实际纳入人群的卵巢反应性进行亚组分析,分为低反应、非低反应、混合反应组;在促性腺激素(gonadotropin hormone,Gn)天数研究时根据用药方式分为洗脱组(停用雌激素预处理5~6 d后开始促排卵)及非洗脱组(雌激素预处理用至促排卵启动前一日)进行分析。在非洗脱组中[WMD=1.07,95%CI(0.83,1.31),I2=66%]预处理后Gn天数显著增加。在洗脱组中[WMD=-0.12,95%CI(-0.45,0.21),I2=0%]Gn天数无明显变化。预处理在低反应亚组中均不影响获卵数[WMD=0.46,95%CI(-0.23,1.16),I2=81%]、临床妊娠率[RR=0.77,95%CI(0.55,1.06),I2=73%]及周期取消率[RR=0.80,95%CI(0.40,1.61),I2=83%];在非低反应组中均不影响获卵数[WMD=0.21,95%CI(-0.69,1.11),I2=22%]、临床妊娠率[RR=0.94,95%CI(0.77,1.14),I2=41%]、活产率[RR=0.82,95%CI(0.62,1.08),I2=0%]及周期取消率[RR=0.89,95%CI(0.54,1.47),I2=2%]。结论:拮抗剂方案中雌激素预处理(非洗脱)会增加Gn天数,不改善非低反应及低反应者体外受精结局。雌激素预处理的应用还需谨慎对待。

Effect of estrogen pretreatment in GnRH antagonist protocol-Meta-analysis

Objective:To evaluate the effect of estrogen pre-treatment in patients with different ovarian response in antagonist protocol.Methods:Randomized controlled trials(RCTs)and retrospective studies about the effect of estrogen pre-treatment in antagonist prorocol were searched in PubMed,Web of Science,China National Knowledge Infrastructure,Wanfang Database.R software was used for meta-analysis.Results:Seven RCTs and two retrospective studies were included.In order to explore the source of heterogeneity,subgroup analysis was used,which was mainly conducted according to the ovarian response of the included population,which were divided into low responders,non-low responders and mixed responders.In the study about gonadotropin hormone(Gn)days,patients were divided into wash-out subgroup and non-wash-out subgroup according to drug use-pattern.Meta-results showed that the number of Gn days increased significantly in the non-wash-out subgroup(WMD=1.07,95%CI[0.83;1.31],I2=66%).The number of Gn days in the wash-out subgroup were not affected(WMD=-0.12,95%CI[-0.45;0.21],I2=0%).In the low-response subgroup,the number of oocytes retrieved(WMD=0.46,95%CI[-0.23;1.16],I2=81%),the fresh cycle clinical pregnancy rate(RR=0.77,95%CI[0.55;1.06],I2=73%)and the cycle cancellation rate(RR=0.80,95%CI[0.40;1.61],I2=83%)were not significantly changed with estrogen pre-treatment.In the non-low-response subgroup,the number of oocytes obtained(WMD=0.21,95%CI[-0.69;1.11],I2=2%),fresh cycle clinical pregnancy rate(RR=0.94,95%CI[0.77;1.14],I2=41%),live birth rate(RR=0.82,95%CI[0.62;1.08],I2=0%)and cycle cancellation rate(RR=0.89,95%CI[0.54;1.47],I2=2%)were not significantly changed with estrogen pre-treatment.Conclusions:Estrogen pre-treatment(with non-wash-out period)in antagonist protocol increases Gn days,dose not improve IVF outcomes in non-low responders and low responders.

黑米总黄酮提取工艺优化及其对茶叶脂肪氧合酶的抑制

以黑米为原料,采用超声波辅助提取黄酮类化合物,用正交试验对提取工艺进行优化。考察了提取物总黄酮对毛尖茶叶脂肪氧合酶(LOX)的抑制作用。结果表明:超声波辅助提取总黄酮的优化条件为乙醇体积分数50%、料液比1∶40(g/mL)、提取温度30℃、超声时间50 min,优化条件下黑米总黄酮提取率为1.98%。黑米中黄酮类化合物对毛尖茶叶脂氧合酶有一定的抑制作用,IC 50为28.14μg/mL。

一种可重构的空间开/闭链6R移动并联机构的设计与分析

移动并联机构的结构和运动模式对其移动性能的影响较大,而传统移动并联机构无法通过切换运动模式来适应复杂的地形环境。为提高移动并联机构的地形适应能力,以平面开/闭链6R(转动副)机构为基本单元,设计了一种可重构的空间开/闭链6R移动并联机构。通过控制单环6R机构的打开与闭合,该可重构移动并联机构可实现3种运动模式。其中,折叠模式时用于携带与储运;足式越障模式时可通过调节转动副角度来适应地面行走;滚动模式时可通过杆件的交替铺展支撑来实现在平面、凹凸或松软地面上的滚动。通过对可重构的空间开/闭链6R移动并联机构进行自由度分析和驱动配置,建立了该机构的运动学模型,并对其足式越障性能以及滚动模式在多种地形下的可行性进行分析。最后通过仿真分析来验证该机构的结构设计及其运动学模型的正确性。结果表明,可重构的空间开/闭链6R移动并联机构的3种运动模式均具有可行性和有效性,其稳定性和环境适应能力较为优良。研究结果为可重构移动机构的设计提供了参考。

An Effective Method of Synthesis and Purification of Organic Nonlinear Salt

A novel organic nonlinear material 4-dimethylamino-N-methyl-4-stilbazolium tosylate which was designed to have a donor/π-conjugated/acceptor structure was synthesized via an effective method.By this method,we have raised yields of every step.Red product with metal luster surface is obtained after repeated purification.The purification process was effective and less-product-lost.Nuclear magnetic resonance study and FTIR were performed to identify the molecular.