目的:人类免疫缺陷病毒(human immunodeficiency virus,HIV)和丙型肝炎病毒(hepatitis C virus,HCV)合并感染是临床常见问题之一。本文通过数据挖掘探讨HIV/HCV合并感染者中医证候分布规律,以期为临床诊治及研究提供依据。方法:采集480...目的:人类免疫缺陷病毒(human immunodeficiency virus,HIV)和丙型肝炎病毒(hepatitis C virus,HCV)合并感染是临床常见问题之一。本文通过数据挖掘探讨HIV/HCV合并感染者中医证候分布规律,以期为临床诊治及研究提供依据。方法:采集480例HIV/HCV合并感染者的症状体征信息,将每一个症状体征作为一个统计变量,有赋值为1,无赋值为0,计算症状体征的频数并通过因子分析提取公因子,以公因子作为变量进行聚类分析。结果:因子分析共得到14个公因子,经聚类分析并经专家讨论后共得到4类证型,分别为脾虚痰瘀、肝郁脾虚、肝肾阴虚、气血亏虚。结论:通过对HIV/HCV合并感染的数据挖掘并归纳出常见的4种证型,可为HIV/HCV合并感染中医药临床诊治提供依据。展开更多
Objective： To analyze the effect of Chinese medicine （CM） on mortality and quality of life （QOL） of acquired immunodeficiency syndrome （AIDS） patients treated with combined antiretroviral therapy （cART）. Meth...Objective： To analyze the effect of Chinese medicine （CM） on mortality and quality of life （QOL） of acquired immunodeficiency syndrome （AIDS） patients treated with combined antiretroviral therapy （cART）. Methods： A random sample of AIDS patients enrolled in the National Chinese Medicine Treatment Trial Program （NCMTP） that met the inclusion criteria was included in this study. NCMTP patients were included as the CM＋cART group, and those not in the NCMTP were included as the cART group. Survival from September 2004 to September 2012 was analyzed by retrospective cohort study. QOL was analyzed by cross-sectional study. Results： The retrospective cohort study included 528 AIDS patients, 322 in the CM＋cART group and 206 in the cART group. After 8 years, the mortality in the CM＋cART group was 3.3/100 person-years, which was lower than the cART group of 5.3/100 person-years （P〈0.05）. The hazard ratio （HR） for mortality in the cART group was 1.6 times that of the CM＋cART group by Cox proportional hazard model analysis. After controlling for gender, age, marital status, education, and CD4＋ T-cell count, the HR was 1.9 times higher in the cART group compared with the CM＋cART group （P〈0.05）. The cross-sectional study investigated 275 AIDS patients. The mean scores of all QOL domains except spirituality/personal beliefs were higher in the CM＋cART group than in the cART group （P〈0.05）. Conclusions： For AIDS patients, CM could help to prolong life, decrease mortality, and improve QOL. However, there were limitations in the study, so prospective studies should be carded out to confirm our primary results.展开更多
文摘目的:人类免疫缺陷病毒(human immunodeficiency virus,HIV)和丙型肝炎病毒(hepatitis C virus,HCV)合并感染是临床常见问题之一。本文通过数据挖掘探讨HIV/HCV合并感染者中医证候分布规律,以期为临床诊治及研究提供依据。方法:采集480例HIV/HCV合并感染者的症状体征信息,将每一个症状体征作为一个统计变量,有赋值为1,无赋值为0,计算症状体征的频数并通过因子分析提取公因子,以公因子作为变量进行聚类分析。结果:因子分析共得到14个公因子,经聚类分析并经专家讨论后共得到4类证型,分别为脾虚痰瘀、肝郁脾虚、肝肾阴虚、气血亏虚。结论:通过对HIV/HCV合并感染的数据挖掘并归纳出常见的4种证型,可为HIV/HCV合并感染中医药临床诊治提供依据。
基金Supported by the National Natural Science Foundation of China(No.81403342 and No.U1604287)the Science and Technology Program of Henan Province(No.172102310325,No.172102310199,No.142102310511)+1 种基金the National Special Science and Technology Program on Major Infectious Diseases of China(2012ZX10005010-001)Special of Scientific Research of Traditional Chinese Medicine of Henan Province in China(No.2015ZY02097,No.2016ZY2036,and No.2015ZY01004)
文摘Objective： To analyze the effect of Chinese medicine （CM） on mortality and quality of life （QOL） of acquired immunodeficiency syndrome （AIDS） patients treated with combined antiretroviral therapy （cART）. Methods： A random sample of AIDS patients enrolled in the National Chinese Medicine Treatment Trial Program （NCMTP） that met the inclusion criteria was included in this study. NCMTP patients were included as the CM＋cART group, and those not in the NCMTP were included as the cART group. Survival from September 2004 to September 2012 was analyzed by retrospective cohort study. QOL was analyzed by cross-sectional study. Results： The retrospective cohort study included 528 AIDS patients, 322 in the CM＋cART group and 206 in the cART group. After 8 years, the mortality in the CM＋cART group was 3.3/100 person-years, which was lower than the cART group of 5.3/100 person-years （P〈0.05）. The hazard ratio （HR） for mortality in the cART group was 1.6 times that of the CM＋cART group by Cox proportional hazard model analysis. After controlling for gender, age, marital status, education, and CD4＋ T-cell count, the HR was 1.9 times higher in the cART group compared with the CM＋cART group （P〈0.05）. The cross-sectional study investigated 275 AIDS patients. The mean scores of all QOL domains except spirituality/personal beliefs were higher in the CM＋cART group than in the cART group （P〈0.05）. Conclusions： For AIDS patients, CM could help to prolong life, decrease mortality, and improve QOL. However, there were limitations in the study, so prospective studies should be carded out to confirm our primary results.
