After removal of the caries or diseased teeth,the alveolar ridge will undergo absorption and atrophy.When the amount of alveolar bone is insufficient,it will cause an inability to perform effective dental implant rest...After removal of the caries or diseased teeth,the alveolar ridge will undergo absorption and atrophy.When the amount of alveolar bone is insufficient,it will cause an inability to perform effective dental implant restoration.In order to control the absorption and promote the repair and regeneration of alveolar ridge,a method of implanting guided bone regeneration(GBR)membranes at the extraction site is often used.In this study,silk fibroin(SF)and poly-L-lactide lactone(PLCL)were used to prepare bilayered guided bone regeneration membranes,and its morphology,hydrophilicity,surface roughness and mechanical properties were studied.At the same time,the drug release behaviors and cell compatibility of the bilayered membranes were studied.The results showed that SF/PLCL bi-layered membranes had good mechanical properties and surface hydrophilicity,and the drug-loaded bi-layered membranes had good cell compatibility.The bilayered membranes fabricated in this study are of potential for applying in the oral health field to promote bone regeneration.展开更多
目的评价光学相干断层扫描血管成像(OCTA)技术在慢性阻塞性肺疾病(慢阻肺)中的应用价值。方法计算机检索PubMed、Embase、Cochrane、Web of science等数据库,检索日期为建库至2024年2月,利用Revman 5.4软件进行meta分析。由2名研究人员...目的评价光学相干断层扫描血管成像(OCTA)技术在慢性阻塞性肺疾病(慢阻肺)中的应用价值。方法计算机检索PubMed、Embase、Cochrane、Web of science等数据库,检索日期为建库至2024年2月,利用Revman 5.4软件进行meta分析。由2名研究人员背对背筛选文献、资料提取、并进行核对,如有分歧则通过讨论或第三人仲裁解决,从而确定最终纳入文献。采用AHRQ量表进行偏倚风险评价。结果初检33篇文献,经过筛选最终纳入6篇符合标准的文献,meta分析结果显示,慢阻肺患者视网膜浅层毛细血管丛密度低于健康组,差异有统计学意义(MD=-1.40,95%CI:-2.33~-0.47,Z=2.96,P=0.003),以凹旁区最为显著(MD=-0.95,95%CI:-1.88~-0.02,Z=2.01,P=0.040)。慢阻肺患者视网膜深层毛细血管丛密度低于健康组,差异有统计学意义(MD=-2.65,95%CI:-4.44~-0.86,Z=2.91,P=0.004),以凹旁区、凹周区为显著[(MD=-2.17,95%CI:-3.44~-0.91,Z=3.37,P<0.001);(MD=-3.33,95%CI:-5.89~-0.77,Z=2.55,P=0.010)]。慢阻肺患者放射状视乳头周围毛细血管丛全区、上半区、下半区、视盘区、盘周区密度均低于健康组,差异均有统计学意义[(MD=-1.51,95%CI:-2.21~-0.81,Z=4.23,P<0.0001);(MD=-1.79,95%CI:-2.95~-0.63,Z=3.01,P=0.003);(MD=-1.92,95%CI:-2.69~-1.16,Z=4.91,P<0.001);(MD=-2.10,95%CI:-3.67~-0.53,Z=2.61,P=0.009);(MD=-1.83,95%CI:-2.91~-0.76,Z=3.34,P<0.001)]。结论OCTA相关眼部生物学指标与慢阻肺的发生可能存在相关性,其在慢阻肺的诊疗中可能具有潜在应用价值。展开更多
为评价长时间冷冻贮藏对刺梨汁的风味品质影响,本研究采用感官评价、电子鼻和顶空固相微萃取气相色谱-质谱分析刺梨汁(Headspace solid phase microextraction gas chromatography-mass spectrometry,HS-SPME-GC-MS)在-20℃冷冻条件下...为评价长时间冷冻贮藏对刺梨汁的风味品质影响,本研究采用感官评价、电子鼻和顶空固相微萃取气相色谱-质谱分析刺梨汁(Headspace solid phase microextraction gas chromatography-mass spectrometry,HS-SPME-GC-MS)在-20℃冷冻条件下不同贮藏时间(0、2、4、6、8 M)的感官特性和香气特征的动态变化。结果表明,共鉴定出127种挥发性化合物,以醇类(31种)、烃类(34种)和酯类(24种)为主。正己醇、叶醇、1-辛烯-3-醇、芳樟醇、正辛醇、α-蒎烯、正己酸乙酯、辛酸乙酯及甲基丁香酚的含量随冷冻贮藏时间的延长呈显著下降趋势(P<0.05),表明青草香、果味和花香味可能会逐渐减弱。壬醛的含量显著增加(P<0.05),由贮藏前3.65μg/100 g增加至贮藏后10.87μg/100 g,导致刺激性不良气味积累。贮藏前刺梨汁的特征香气显著,在贮藏后期,特征香气降低或损失,而松木和刺激气味尤为突出。基于相对气味活性值(ROAV)分析得到鲜刺梨汁的挥发性特征成分(ROAV>1)有12种,特征成分的含量在贮藏结束后减少了60%~90%。基于偏最小二乘法判别(Partial least squares discriminant analysis,PLS-DA)和变量重要性投影值(Variable importance in the projection,VIP),确定了贮藏8个月是刺梨汁中挥发性化合物高度变化的分界点,筛选出10种挥发性化合物可作为区分刺梨汁在特定冷冻储存不同时间条件下的重要标记物。本研究结果为判别刺梨汁冷冻贮藏过程中的品质监测和贮藏条件优化提供依据。展开更多
基金Natural Science Foundation for Key Program of the Jiangsu Higher Education Institutions,China(No.19KJA610004)Natural Science Foundation of Jiangsu Province,China(No.BK20161254)+1 种基金China Postdoctoral Science Foundation(No.2019M651947)Mandatory Projects of Nantong Municipal Science and Technology Plan,China(No.JC2018004)
文摘After removal of the caries or diseased teeth,the alveolar ridge will undergo absorption and atrophy.When the amount of alveolar bone is insufficient,it will cause an inability to perform effective dental implant restoration.In order to control the absorption and promote the repair and regeneration of alveolar ridge,a method of implanting guided bone regeneration(GBR)membranes at the extraction site is often used.In this study,silk fibroin(SF)and poly-L-lactide lactone(PLCL)were used to prepare bilayered guided bone regeneration membranes,and its morphology,hydrophilicity,surface roughness and mechanical properties were studied.At the same time,the drug release behaviors and cell compatibility of the bilayered membranes were studied.The results showed that SF/PLCL bi-layered membranes had good mechanical properties and surface hydrophilicity,and the drug-loaded bi-layered membranes had good cell compatibility.The bilayered membranes fabricated in this study are of potential for applying in the oral health field to promote bone regeneration.
文摘目的评价光学相干断层扫描血管成像(OCTA)技术在慢性阻塞性肺疾病(慢阻肺)中的应用价值。方法计算机检索PubMed、Embase、Cochrane、Web of science等数据库,检索日期为建库至2024年2月,利用Revman 5.4软件进行meta分析。由2名研究人员背对背筛选文献、资料提取、并进行核对,如有分歧则通过讨论或第三人仲裁解决,从而确定最终纳入文献。采用AHRQ量表进行偏倚风险评价。结果初检33篇文献,经过筛选最终纳入6篇符合标准的文献,meta分析结果显示,慢阻肺患者视网膜浅层毛细血管丛密度低于健康组,差异有统计学意义(MD=-1.40,95%CI:-2.33~-0.47,Z=2.96,P=0.003),以凹旁区最为显著(MD=-0.95,95%CI:-1.88~-0.02,Z=2.01,P=0.040)。慢阻肺患者视网膜深层毛细血管丛密度低于健康组,差异有统计学意义(MD=-2.65,95%CI:-4.44~-0.86,Z=2.91,P=0.004),以凹旁区、凹周区为显著[(MD=-2.17,95%CI:-3.44~-0.91,Z=3.37,P<0.001);(MD=-3.33,95%CI:-5.89~-0.77,Z=2.55,P=0.010)]。慢阻肺患者放射状视乳头周围毛细血管丛全区、上半区、下半区、视盘区、盘周区密度均低于健康组,差异均有统计学意义[(MD=-1.51,95%CI:-2.21~-0.81,Z=4.23,P<0.0001);(MD=-1.79,95%CI:-2.95~-0.63,Z=3.01,P=0.003);(MD=-1.92,95%CI:-2.69~-1.16,Z=4.91,P<0.001);(MD=-2.10,95%CI:-3.67~-0.53,Z=2.61,P=0.009);(MD=-1.83,95%CI:-2.91~-0.76,Z=3.34,P<0.001)]。结论OCTA相关眼部生物学指标与慢阻肺的发生可能存在相关性,其在慢阻肺的诊疗中可能具有潜在应用价值。
文摘为评价长时间冷冻贮藏对刺梨汁的风味品质影响,本研究采用感官评价、电子鼻和顶空固相微萃取气相色谱-质谱分析刺梨汁(Headspace solid phase microextraction gas chromatography-mass spectrometry,HS-SPME-GC-MS)在-20℃冷冻条件下不同贮藏时间(0、2、4、6、8 M)的感官特性和香气特征的动态变化。结果表明,共鉴定出127种挥发性化合物,以醇类(31种)、烃类(34种)和酯类(24种)为主。正己醇、叶醇、1-辛烯-3-醇、芳樟醇、正辛醇、α-蒎烯、正己酸乙酯、辛酸乙酯及甲基丁香酚的含量随冷冻贮藏时间的延长呈显著下降趋势(P<0.05),表明青草香、果味和花香味可能会逐渐减弱。壬醛的含量显著增加(P<0.05),由贮藏前3.65μg/100 g增加至贮藏后10.87μg/100 g,导致刺激性不良气味积累。贮藏前刺梨汁的特征香气显著,在贮藏后期,特征香气降低或损失,而松木和刺激气味尤为突出。基于相对气味活性值(ROAV)分析得到鲜刺梨汁的挥发性特征成分(ROAV>1)有12种,特征成分的含量在贮藏结束后减少了60%~90%。基于偏最小二乘法判别(Partial least squares discriminant analysis,PLS-DA)和变量重要性投影值(Variable importance in the projection,VIP),确定了贮藏8个月是刺梨汁中挥发性化合物高度变化的分界点,筛选出10种挥发性化合物可作为区分刺梨汁在特定冷冻储存不同时间条件下的重要标记物。本研究结果为判别刺梨汁冷冻贮藏过程中的品质监测和贮藏条件优化提供依据。
