Flow characteristics and hot workability of a typical low-alloy high-strength steel during multi-pass deformation

Heavy components of low-alloy high-strength(LAHS) steels are generally formed by multi-pass forging. It is necessary to explore the flow characteristics and hot workability of LAHS steels during the multi-pass forging process, which is beneficial to the formulation of actual processing parameters. In the study, the multi-pass hot compression experiments of a typical LAHS steel are carried out at a wide range of deformation temperatures and strain rates. It is found that the work hardening rate of the experimental material depends on deformation parameters and deformation passes, which is ascribed to the impacts of static and dynamic softening behaviors. A new model is established to describe the flow characteristics at various deformation passes. Compared to the classical Arrhenius model and modified Zerilli and Armstrong model, the newly proposed model shows higher prediction accuracy with a confidence level of 0.98565. Furthermore, the connection between power dissipation efficiency(PDE) and deformation parameters is revealed by analyzing the microstructures. The PDE cannot be utilized to reflect the efficiency of energy dissipation for microstructure evolution during the entire deformation process, but only to assess the efficiency of energy dissipation for microstructure evolution in a specific deformation parameter state.As a result, an integrated processing map is proposed to better study the hot workability of the LAHS steel, which considers the effects of instability factor(IF), PDE, and distribution and size of grains. The optimized processing parameters for the multi-pass deformation process are the deformation parameters of 1223–1318 K and 0.01–0.08 s^(-1). Complete dynamic recrystallization occurs within the optimized processing parameters with an average grain size of 18.36–42.3 μm. This study will guide the optimization of the forging process of heavy components.

The Mechanism of Cornus officinalis Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

Objective: To investigate effects of Cornus officinalis Total Glycosides (COTG) and Cornus Polysaccharide (CP) on myocardial protection and on expression of mitochondria biogenesis related gene of acute myocardial infarction (AMI) rats, Materials and Methods: Ninety-six SD rats of SPF level were randomly divided into 5 groups: sham operation group, model group, preventive treatment group, COTG treatment group, CP treatment group, and there were 12 cases in each one. By legating the left anterior descending branch of coronary artery method, acute myocardial infarction model was established. The rat of sham operation group and model group was intragastric administered with physiological saline;other groups were given with corresponding drugs. The cardiac function, the myocardial infarct area, the expression of mitochondrial biogenesis genes such as PGC-1α, PGC-1β, NRF-1mRNA and GSK-3β mRNA, GSK-3β Protein Expression were analyzed. Results: The results revealed that compared with model group, myocardial infarction size, LVDs, LVDd, LVESV, LVEDP, and -dp/dt decreased;LVSP increased in preventive treatment group, COTG treatment group, and CP treatment group (p < 0.05);LVEDV increased in preventive treatment group (p < 0.05), PGC 1 alpha, and PGC 1 beta;the NRF-1 mRNA expression increased in preventive treatment group, COTG treatment group, and CP treatment group (p < 0.05). Compared with CP and COTG treatment group, PGClpha, beta PGC 1, the NRF-1 mRNA expression increased in preventive treatment group (p < 0.05). Compared with the sham operation group, GSK-3 beta mRNA and protein expression increased in model group, preventive treatment group, COTG treatment group, and CP treatment group (p < 0.05). Compared with model group, GSK-3 beta mRNA expression reduced in preventive treatment group, COTG treatment group, and CP treatment group (p Cornus officinalis total glycosides and Cornus polysaccharides can effectively protect myocardial mitochondria of acute myocardial infarction rats by activating GSK-3β signaling pathways, and reduce the myocardial infarct size, which has great significance for improving cardiac function.

Effects of Cangfudaotan Tang on Expression of Organic Anion Transporting Polypeptide (oatp2b1) in Liver and Kidney Tissues of Rats with Phlegm Dampness Type Polycystic Ovary Syndrome (PCOS)

Objective: To explore the effect of Cangfudaotan Tang on phlegm dampness type of PCOS and the role of oatp2b1 in transportation and transformation of phlegm dampness. Methods: 36 SD female rats were randomly divided into three groups: blank control group, model group and Cangfudaotan Tang group, 12 cases in each one. After PCOS rat models were made, rats of Cangfudaotan Tang group were treated with Cangfudaotan Tang (1.42 g/kg/d) by intragastric administration for 14 days;blank control and model group were given with isodose saline. The expression of oatp2b1 mRNA/Protein in liver and kidney tissues was measured and the level of testosterone (T), follicle stimulating hormone(FSH), estradiol (E2), luteinizing hormone(LH), Serum total cholesterol (TG), Triacylglycerols (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were detected at the same time. Results: Compared with blank control group, the expression of oatp2b1 mRNA and the level of TC, TG, LDL, LH, FSH, T in model group were significantly increased (P < 0. 05), while the level of HDL was significantly decreased (P < 0. 05);compared with model group, the expression of oatp2b1 mRNA and the level of TC, TG, LDL in Cangfudaotan Tang group were significantly lowered (P < 0.05);the level of HDL was significantly higher;the oatp2b1 protein in kidney and liver tissues had different degrees of expression, while there was no statistical significance among the three groups. Conclusions: Oatp2b1 might be one of the material bases participating in transportation and transformation of phlegmy dampness. The mechanism of Cangfudaotan Tang treating phlegm dampness type of PCOS may be achieved by regulating the expression of oatp2b1.

Insight into the spoilage heterogeneity of meat-borne bacteria isolates with high-producing collagenase

Chilled chicken is inevitably contaminated by microorganisms during slaughtering and processing,resulting in spoilage.Cutting parts of chilled chicken,especially wings,feet,and other skin-on products,are abundant in collagen,which may be the primary target for degradation by spoilage microorganisms.In this work,a total of 17 isolates of spoilage bacteria that could secrete both collagenase and lipase were determined by raw-chicken juice agar(RJA)method,and the results showed that 7 strains of Serratia,Aeromonas,and Pseudomonas could significantly decompose the collagen ingredients.The gelatin zymography showed that Serratia liquefaciens(F5)and(G7)had apparent degradation bands around 50 kDa,and Aeromonas veronii(G8)and Aeromonas salmonicida(H8)had a band around.65 and 95 kDa,respectively.The lipase and collagenase activities were detected isolate-by-isolate,with F5 showing the highest collagenase activity.For spoilage ability on meat in situ,F5 performed strongest in spoilage ability,indicated by the total viable counts,total volatile basic nitrogen content,sensory scores,lipase,and collagenase activity.This study provides a theoretical basis for spoilage heterogeneity of strains with high-producing collagenase in meat.

The lactylation index predicts the immune microenvironment and prognosis of pan-cancer patients

Background:Protein lactylation is a new way for the“metabolic waste”lactic acid to perform novel functions.Nevertheless,our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains imited.The construction of a scoring system for lactylation to predict the prognosis of pancancer patients and to evaluate the tumor immune microenvironment(TIME)would improve our understanding of the clinical significance of lactylation.Methods:Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma(PAAD)patients.Subsequently,a scoring system was developed using the least absolute shrinkage and selection operator(LASSO)regression.Internal validation and external validation were both conducted to assess and confirm the predictive accuracy of the scoring system.Finally,leucine rich repeat containing 1(LRRC1),a newly discovered lactylation-related gene,was analyzed in PAAD in vitro.Results:Utilizing the profiles of 332 lactylation-related genes,a total of 177 patients with PAAD were segregated into two distinct groups.LacCluster^(high) patients had a poorer prognosis than LacCluster^(low) patients.Through the differential analysis between the LacCluster^(high) and LacCluster^(low) groups,we identified additional genes associated with lactylation.These genes were then integrated to construct the LacCluster-enhanced system,which enabled more accurate prognosis prediction for patients with PAAD.Then,a lactylation index containing three genes(LacI-3)was constructed using LASSO regression.This was done to enhance the usability of the LacCluster-enhanced system in the clinic.Compared to those in the LacI-3^(high) subgroup,patients in the LacI-3^(low) subgroup exhibited increased expression of immune checkpoint-related genes,more immune cell infiltration,lower tumor mutation burdens,and better prognoses,indicating a“hot tumor”phenotype.Moreover,knocking down the expression of LRRC1,the hub gene in the LacI-3 scoring system,inhibited PAAD cell invasion,migration,and proliferation in vitro.Ultimately,the significance of LacI-3 across cancers was confirmed.Conclusion:Our findings strongly imply that protein lactylation may represent a new approach to diagnosing and treating malignant tumors.

Geometric Mean Decomposition Based Hybrid Precoding for Millimeter-Wave Massive MIMO

Hybrid precoding can reduce the number of required radio frequency(RF)chains in millimeter-Wave(mmWave) massive MIMO systems. However, existing hybrid precoding based on singular value decomposition(SVD) requires the complicated bit allocation to match the different signal-to-noise-ratios(SNRs) of different sub-channels. In this paper,we propose a geometric mean decomposition(GMD)-based hybrid precoding to avoid the complicated bit allocation. Specifically,we seek a pair of analog and digital precoders sufficiently close to the unconstrained fully digital GMD precoder. To achieve this, we fix the analog precoder to design the digital precoder, and vice versa. The analog precoder is designed based on the orthogonal matching pursuit(OMP) algorithm, while GMD is used to obtain the digital precoder. Simulations show that the proposed GMD-based hybrid precoding achieves better performance than the conventional SVD-based hybrid precoding with only a slight increase in complexity.

Umbilical cord-derived mesenchymal stem cells retain immunomodulatory and anti-oxidative activities after neural induction

The immunomodulatory and anti-oxidative activities of differentiated mesenchymal stem cells contribute to their therapeutic efficacy in cell-replacement therapy. Mesenchymal stem cells were isolated from human umbilical cord and induced to differentiate with basic fibroblast growth factor, nerve growth factor, epidermal growth factor, brain-derived neurotrophic factor and forskolin. The mesenchymal stem cells became rounded with long processes and expressed the neural markers, Tujl, neurofilament 200, microtubule-associated protein-2 and neuron-specific enolase. Nestin expression was significantly reduced after neural induction. The expression of immunoregulatory and anti-oxidative genes was largely unchanged prior to and after neural induction in mesenchymal stem cells. There was no significant difference in the effects of control and induced mesenchymal stem cells on lymphocyte proliferation in co-culture experiments. However, the expression of human leukocyte antigen-G decreased significantly in induced neuron-like cells. These results suggest that growth factor-based methods enable the differentiation of mesenchymal stem cell toward immature neuronal-like cells, which retain their immunomodulatory and anti-oxidative activities.

Hydrophobicity changes of polluted silicone rubber introduced by spatial and dose distribution of plasma jet

The hydrophobicity of polluted silicone rubber was improved rapidly under plasma jet treatment.It is an important phenomenon of the interaction between the plasma jet and the porous surface,and shows a wide application prospect in the power system.In this process,the spatial characteristics and dose of plasma jet are very important.Therefore,the variation of hydrophobicity of polluted silicone rubber under plasma jet treatment was studied,and the spatial characteristics and dose of plasma jet on polluted silicone rubber were also investigated in the work.The results show that the surface property(hydrophilic or hydrophobic)depended on the dose of plasma applied to the surface.The effective treated area was a circle,and the contact angles changed along the radial direction of the circle.This was attributable to the diffusion of plasma bullets on the surface and the distribution of plasma species.The plasma dose could be characterized by the energy density of the plasma applied on the surface.With the increase of plasma dose,the surface contact angles first increased rapidly and then decreased gradually.

Clinical,biochemical and genetic characteristics of familial hypercholesterolemia with and without type 2 diabetes

Background Though type 2 diabetes mellitus(T2DM)is an important and independent risk factor for coronary artery disease(CAD)in general population,whether this feature also exists in patients with familial hypercholesterolemia(FH)is less determined.The current study aims to characterize the clinical,laboratory,coronary and genetic characteristics of the FH patients with T2DM compared with FH alone.

Non-obstructive coronary artery disease and cardiovascular events in patients with angina-like chest pain detected by coronary angiography:a Chinese cohort study

Objective The utility of non-obstructive coronary artery diseases(NOCAD) in cardiovascular events (CVE) among Chinese patients has less been evaluated. Our objective was to investigate the prognostic value of NOCAD in patients with angina-like chest pain detected by coronary angiography (CAG) in a large Chinese cohort study.

Effect of chemical ordering annealing on superelasticity of Ni-Mn-Ga-Fe ferromagnetic shape memory alloy microwires

Ni50Mn25Ga20Fe5 ferromagnetic shape memory alloy microwires with diameters of^30-50μm and grain sizes of^2-5μm were prepared by melt-extraction technique.A step-wise chemical ordering annealing was carried out to improve the superelasticity strain and recovery ratio which were hampered by the internal stress,compositional inhomogeneity,and high-density defects in the as-extracted Ni50Mn25Ga20Fe5 microwires.The annealed microwires exhibited enhanced atomic ordering degree,narrow thermal hysteresis,and high saturation magnetization under a low magnetic field.As a result,the annealed microwire showed decreased superelastic critical stress,improved reversibility,and a high superelastic strain(1.9%)with a large recovery ratio(>96%).This kind of filamentous material with superior superelastic effects may be promising materials for minor-devices.

Analysis of the therapeutic effect of transhepatic arterial embolization combined with microwave ablation for hepatic epithelioid hemangioendothelioma

Objective:To analyze the imaging results of hepatic epithelioid hemangioendothelioma(HEHE)and the effect of transhepatic arterial embolization(TAE)combined with microwave ablation(MWA)in the treatment of HEHE.Methods:A retrospective analysis of four patients with HEHE diagnosed by pathological diagnosis of liver biopsy was performed.

The MRI manifestations of intramedullary germinoma of the spinal cord:a case report and review of the literature

Primary germinoma in the spinal cord is very rare. Preoperative diagnosis is important because germinomas are sensitive to radiation therapy and chemotherapy so that treatment trends and prognosis differ from other intramedullary spinal cord tumors. Preoperative radiologic diagnosis is very difficult because of this rarity. In this case a 22-year-old woman with a 4-month history of gradual numbness and weakness of both lower extremities was found to have a solid tumor in the thoracic cord between the T9 and T11 vertebral bodies. No other neoplastic lesion was found inside or outside the central nervous system. The patient underwent surgery, and the intrarnedullary lesion was almost totally resected. Serum HCG was elevated postoperatively without pregnancy. The pathological diagnosis was conclusively that of a germinoma. The previous 23 cases of primary spinal cord germinoma were reviewed for comparison.

Application of diffusion tensor imaging in spinal cord injury

Diffusion tensor imaging(DTI)technique can detect the dispersion of water molecules in the white matter of the spinal cord,the integrity of the spinal fiber bundle,and the pathological changes after injury.Clinically,DTI is sensitive to acute and chronic spinal cord injuries,and is most commonly used for the diagnosis of cervical spondylotic myelopathy,multiple sclerosis,secondary brain damage after spinal cord injury,and spinal nerve root damage.In animal studies involving rats,monkeys,cattle,cats,pigs,dogs,etc.,DTI could quantitatively analyze the microstructural and pathological changes of the injured spinal cord and provide a powerful auxiliary diagnosis for behavioral evaluation.

Effect of the Cladding Layer Cavity on the Efficiency of 650 nm Resonant Cavity Light Emitting Diodes

High efficiency 650 nm resonant cavity light emitting diodes (RCLEDs) with a cladding layer cavity are reported. The epitaxial structure is grown with a metal-organic chemical vapor deposition (MOCVD) system. Al 0.5Ga 0.5 As/Al As is used for the distributed Bragg reflectors (DBRs), and GaInP/AlGaInP multiple-quantum wells for the active region. Two RCLED samples have been fabricated, one with a cladding layer cavity and the other without. Experimental results show that the cladding layer cavity can improve the internal quantum efficiency effectively, so that an external quantum efficiency of 7.4% at 20 mA is reached. Meanwhile, the sample with cladding layer cavity also shows a spectral stability as the injected current changing from 20 mA to 100 mA.

Expert Recommendation in Community Question Answering via Heterogeneous Content Network Embedding

ExpertRecommendation(ER)aims to identify domain experts with high expertise and willingness to provide answers to questions in Community Question Answering(CQA)web services.How to model questions and users in the heterogeneous content network is critical to this task.Most traditional methods focus on modeling questions and users based on the textual content left in the community while ignoring the structural properties of heterogeneous CQA networks and always suffering from textual data sparsity issues.Recent approaches take advantage of structural proximities between nodes and attempt to fuse the textual content of nodes for modeling.However,they often fail to distinguish the nodes’personalized preferences and only consider the textual content of a part of the nodes in network embedding learning,while ignoring the semantic relevance of nodes.In this paper,we propose a novel framework that jointly considers the structural proximity relations and textual semantic relevance to model users and questions more comprehensively.Specifically,we learn topology-based embeddings through a hierarchical attentive network learning strategy,in which the proximity information and the personalized preference of nodes are encoded and preserved.Meanwhile,we utilize the node’s textual content and the text correlation between adjacent nodes to build the content-based embedding through a meta-context-aware skip-gram model.In addition,the user’s relative answer quality is incorporated to promote the ranking performance.Experimental results show that our proposed framework consistently and significantly outperforms the state-of-the-art baselines on three real-world datasets by taking the deep semantic understanding and structural feature learning together.The performance of the proposed work is analyzed in terms of MRR,P@K,and MAP and is proven to be more advanced than the existing methodologies.

LDL-C rebound after long-term evolocumab treatment and intravascular imaging evidence in a familial hypercholesterolemia patient with early-onset myocardial infarction

Patients with familial hypercholesterolemia(FH)have elevated low-density lipoprotein cholesterol(LDL-C)levels and are at high risk of premature cardiovascular disease.1 Heterozygous FH(HeFH)is one of the commonest genetic disorders,and is more frequent among those with ischemic heart disease(IHD),atherosclerotic cardiovascular disease(ASCVD)and premature IHD.

High Wall-Plug Efficiency 1060 nm High Power Semiconductor Laser

By analyzing the factors which affect the wall-plug efficiency of semiconductor Laser Diodes (LDs), a high efficiency 1060 nm LD was designed, including active region, waveguide layers, and cladding layers. The simulation result shows that the component of In in InGaAs in the active region cannot be too small, otherwise the thickness of InGaAs active layer will exceed the critical thickness, meanwhile the asymmetric large optical cavity can decrease the cavity loss effectively. The epitaxial structure was grown by MOCVD, experimental results of varying cavity length showed that the internal quantum efficiency reached 98.57%, and the cavity loss was only 0.273 cm?1. Devices with 4 mm-cavity-length and 100 μm-strip-width were fabricated, 47.4% wall-plug efficiency was reached under QCW pulse condition at room temperature, and the peak wavelength was 1059.4 nm.