Indian plate blocked by the thickened Eurasian crust in the middle of the continental collision zone of southern Tibet

The relationship of the crustal contact between the Indian and Eurasian plates is a key issue in understanding crustal thickening and the subduction of the Indian lithosphere beneath the Qinghai-Tibetan Plateau. Across the middle of the Yarlung-Zangbo Suture(YZS), we deployed an ~450-km-long SN-trending wide-angle reflection/refraction profile to observe the P-wave velocity(vP) structure beneath the northern Himalaya and the southern plateau. Our results show that, 1. the high vP(~7.1 km/s) indicates that the Indian lower crust extends no more than 50 km north of the YZS. 2. The lower crust beneath the southern part of the plateau features an extremely low vP(<6.7 ± 0.2 km/s). 3. Compared with the velocities of several typical crustal lithologies in different temperature regimes, the low vPin the lower crust can be explained by felsic-intermediate granulite, which has prevented the lower crust from further eclogitization. We propose that the dip angle of the Indian lithospheric slab beneath the YZS is partly controlled by the composition of the lower crust of the plateau. In the northern middle YZS, the crust of the southern plateau is too thick and blocks the northward advancement of the Indian lower crust, resulting in the subduction of the Indian lithospheric slab into the upper mantle. The lower crust in western and eastern Lhasa is dominated by a mafic composition, and it was delaminated after eclogitization before the Miocene. The void zone generated by delamination favors the flattening and underthrusting of the Indian lower crust.

31.38 Gb/s GaN-based LED array visible light communication system enhanced with V-pit and sidewall quantum well structure

Although the 5G wireless network has made significant advances,it is not enough to accommodate the rapidly rising requirement for broader bandwidth in post-5G and 6G eras.As a result,emerging technologies in higher frequencies including visible light communication(VLC),are becoming a hot topic.In particular,LED-based VLC is foreseen as a key enabler for achieving data rates at the Tb/s level in indoor scenarios using multi-color LED arrays with wavelength division multiplexing(WDM)technology.This paper proposes an optimized multi-color LED array chip for high-speed VLC systems.Its long-wavelength GaN-based LED units are remarkably enhanced by V-pit structure in their efficiency,especially in the“yellow gap”region,and it achieves significant improvement in data rate compared with earlier research.This work investigates the V-pit structure and tries to provide insight by introducing a new equivalent circuit model,which provides an explanation of the simulation and experiment results.In the final test using a laboratory communication system,the data rates of eight channels from short to long wavelength are 3.91 Gb/s,3.77 Gb/s,3.67 Gb/s,4.40 Gb/s,3.78 Gb/s,3.18 Gb/s,4.31 Gb/s,and 4.35 Gb/s(31.38 Gb/s in total),with advanced digital signal processing(DSP)techniques including digital equalization technique and bit-power loading discrete multitone(DMT)modulation format.

Effect of preparation methods on the structure and catalytic performance of Fe–Zn/K catalysts for CO2 hydrogenation to light olefins

Potassium promoted iron–zinc catalysts prepared by co-precipitation method(C–Fe–Zn/K),solvothermal method(S–Fe–Zn/K)and hydrothermal method(H–Fe–Zn/K)could selectively convert CO_2to light olefins,respectively.The physicochemical properties of the obtained catalysts were determined by SEM,N_2physisorption,XRD,H_2-TPR,CO_2-TPD and XPS measurements.The results demonstrated that preparation methods had great influences on the morphology,phase structures,reduction and adsorption behavior,and hence the catalytic performance of the catalysts.The samples prepared by hydrothermal and co-precipitation method generated small uniform particles and led to lower specific surface area.In contrast,microspheres with larger specific surface area were formed by self-assembly of nanosheets using solvothermal method.ZnFe_2O_4was the only detectable phase in the fresh C–2Fe–1Zn/K,S–3Fe–1Zn/K and S–2Fe–1Zn/K samples.ZnFe_2O_4and ZnO co-existed with increasing Zncontent in S–1Fe–1Zn/K sample,while ZnO and Fe_2O_3could be observed over H–2Fe–1Zn/K sample.All the used samples contained Fe_3O_4,ZnO and Fe_5C_2.The peak intensity of ZnO was strong in the AR-H–2Fe–1Zn/K sample while it was the lowest in the AR-C–2Fe–1Zn/K sample after reaction.The formation of ZnFe_2O_4increased the interaction between iron and zinc for C–2Fe–1Zn/K and S–Fe–Zn/K samples,causing easier reduction of Fe_2O_3to Fe_3O_4.The surface basicity of the sample prepared by co-precipitation method was much more than that of the other two methods.During CO_2hydrogenation,all the catalysts showed good activity and olefin selectivity.The CO selectivity was increased with increasing Zncontent over S–Fe–Zn/K samples.H–2Fe–1Zn/K catalyst preferred to the production of C_5^+hydrocarbons.CO_2conversion of 54.76%and C_2~=–C_4~=contents of 57.38%were obtained on C–2Fe–1Zn/K sample,respectively.

Study on Water Conservation Capacity of Litter from Different Types of Forest in Caohai Basin

[Objective]The research aimed to understand water conservation capacity of litter from different forest types in Caohai basin. [Method] Current storage amount,water holding capacity and precipitation interception ability of litter from 4 types of forest were investigated and studied. [Result]The order of exist litter amount was grass slope ＆gt;shrub forest ＆gt;mixed broad leaf-conifer forest ＆gt;coniferous forest. The order of natural water holding capacity was mixed broad leafconifer forest ＆gt; coniferous forest ＆gt; grass slope ＆gt; shrub forest. The relevance between water holding capacity of litter and soaking time was in line with this formula： y = kln（ x） ＋ b. During 0-120 min of litter soaking,water holding capacity increased rapidly. After 120 min,the increasing trend remained flat until closing to the maximum water holding capacity. The relevance between water absorption rate of litter and soaking time was in line with this formula： y = a ＋ bx-1. In the beginning of soaking,water absorption rates of litter from different woodlands showed great difference. As soaking time went by,water absorption rates of litter from different woodlands all declined sharply. During 0-120 min,declining velocity of water absorption rate was quicker. After 120 min,the declining trend tended to be slow. The maximum water holding capacity of litter presented the order of shrub forest ＆gt; mixed broad leafconifer forest ＆gt; grass slope ＆gt; coniferous forest. The maximum precipitation interception amount of litter presented the order of shrub forest ＆gt; grass slope ＆gt; mixed broad leafconifer forest ＆gt; coniferous forest. Effective impounding capacity of litter presented the order of shrub forest ＆gt; mixed broad leafconifer forest ＆gt; grass slope ＆gt; coniferous forest. [Conclusion]The research could provide support for the construction of water conservation forest in Caohai basin.

Comparative study of the stoichiometric characteristics of karst and non-karst forests in Guizhou, China

Carbon (C), nitrogen (N), and phosphorous (P) levels and their stoichiometry in plant components (leaves, branch trunks, roots) of trees in a karst forest and non-karst forest are compared. The results show that the C contents, C:N and C:P ratios of dominant species in the karst forest were lower than those in the non-karst forest, but the N and P and the N:P ratio were higher;C:N:P ratios in plant organs of trees in the karst forest were in the order of trunks>roots>branches>leaves. However, C:N:P ratio in the non-karst forest trees were trunks>branches>roots>leaves. Moreover, ratio of C:N:P in trunks was highest and lowest in leaves in both forests. In non-karst forest trees, N:P was in the order of leaves> roots>branches>trunks. There were no significant differences in the ratio of N:P in different plant components of trees in the karst forest. However, in karst and non-karst forest trees, the ratio of N:P in leaves was highest;positive correlations between N and P contents, and N and N:P ratios were observed in both karst and non-karst forests (p<0.001). Negative correlations between P and N:P ratios (p<0.05) were observed in karst forest trees, while positive correlations were observed in non-karst forest trees.

Efficacy of Cytidine-5'-diphosp-bocholine Combined with Compound Anisodine in the Treatment of Early Optic Nerve Contusion

Purpose:To investigate the efficacy of anisodine combined with cytidine-5'-diphosp-bocholine (citicoline) in the treatment of early optic nerve contusion.Methods:A total of 33 subjects eligible for inclusion were selected from 105 patients clinically diagnosed with optic nerve contusion.These patients were subsequently divided into the control group (n =16) and the intervention group (n =17).In the control group,the participants received therapy consisting of glucocorticoids,mannitol,vasodilators and vitamin B.The patients in the intervention group additionally received anisodine in combination with citicoline.The visual acuity was graded on a scale from 0 to 8.Results:Prior to treatment,.the 25th,50th and 75th percentiles of visual acuity grade were 3,4 and 6.75 for the controls,and 3,4 and 6.5 for the patients in the intervention group (P=0.97).After treatment,the 25th,50th and 75th percentiles of visual acuity grade were 4,6 and 7.75 in the control group,and 7,7 and 8 in the intervention group (P=0.046).A significant difference was observed in both control (P=0.005) and intervention groups(P=0.001) when comparing presenting visual acuity before and after treatment.Conclusion:The combination of anisodine and citicoline with standard steroid and mannitol therapy appears to be effective in the treatment of early optic nerve contusion.

康复阶梯图护理对脑卒中患者依从性及效果观察

目的探讨康复阶梯图护理对脑卒中患者依从性及效果。方法选择2014年12月-2018年12月我院接收治疗的脑卒中患者总共60例作为本次的研究对象,并按照随机的方法分为两组,即研究组(n=30)与对照组(n=30);其中对照组使用常规的护理方式,研究组使用康复阶梯图的护理方式;观察并比较两组的依从程度以及护理的效果。结果研究组的依从率是100.00%,对照组的依从率是83.33%,研究组显著高于对照组(P<0.05);研究组在护理后的CSS评分显著低于对照组,同时FMA评分显著高于对照组(P<0.05)。结论在对脑卒中患者的护理过程中,结合使用康复阶梯图这种方法可以比较有效地提高患者的依从性,护理的效果也非常理想,在临床治疗中可以广泛使用。

The effects of Er^(3+) ion concentration on 2.0-μm emission performance in Ho^(3+)/Tm^(3+) co-doped Na_(5)Y_(9)F_(32) single crystal under 800-nm excitation

Na_(5)Y_(9)F_(32) single crystals doped with ~0.8-mol% Ho^(3+),~1-mol% Tm^(3+),and various Er^(3+) ion concentrations were prepared by a modified Bridgman method.The effects of Er^(3+)ion concentration on 2.0-μm emission excited by an800-nm laser diode were investigated with the help of their spectroscopic properties.The intensity of 2.0-μm emission reached to maximum when the Er^(3+) ion concentration was ~1 mol%.The energy transfer mechanisms between Er^(3+),Ho^(3+),and Tm^(3+) ions were identified from the change of the absorption spectra,the emission spectra,and the measured decay curves.The maximum 2.0-μm emission cross section of the Er^(3+)/Ho^(3+)/Tm^(3+)tri-doped Na_(5)Y_(9)F_(32) single crystal reached 5.26 × 10^(-21) cm^(2).The gain cross section spectra were calculated according to the absorption and emission cross section spectra.The cross section for ~2.0-μm emission became a positive gain once the inversion level of population was reached 30%.The energy transfer efficiency was further increased by 11.81% through the incorporation of Er^(3+) ion into Ho^(3+)/Tm^(3+) system estimated from the measured lifetimes of Ho^(3+)/Tm^(3+)-and Er^(3+)/Ho^(3+)/Tm^(3+)-doped Na_(5)Y_(9)F_(32)single crystals.The present results illustrated that the Er^(3+)/Ho^(3+)/Tm^(3+)tri-doped Na_(5)Y_(9)F_(32) single crystals can be used as promising candidate for 2.0-μm laser.

Flexible 2 × 2 multiple access visible light communication system based on an integrated parallel GaN/InGaN micro-photodetector array module

In recent studies, visible light communication(VLC) has been predicted to be a prospective technique in the future 6G communication systems. To suit the trend of exponentially growing connectivity, researchers have intensively studied techniques that enable multiple access(MA) in VLC systems, such as the MIMO system based on LED devices to support potential applications in the Internet of Things(IoT) or edge computing in the nextgeneration access network. However, their transmission rate is limited due to the intrinsic bandwidth of LED.Unfortunately, the majority of visible light laser communication (VLLC) research with beyond 10 Gb/s data rates concentrates on point-to-point links, or using discrete photodetector(PD) devices instead of an integrated array PD. In this paper, we demonstrated an integrated PD array device fabricated with a Si-substrated GaN/InGaN multiple-quantum-well(MQW) structure, which has a 4 × 4 array of 50 μm × 50 μm micro-PD units with a common cathode and anode. This single-integrated array successfully provides access for two different transmitters simultaneously in the experiment, implementing a 2 × 2 MIMO-VLLC link at 405 nm. The highest data rate achieved is 13.2 Gb/s, and the corresponding net data rate(NDR) achieved is 12.27 Gb/s after deducing the FEC overhead, using 2.2 GHz bandwidth and superposed PAM signals. Furthermore, we assess the Huffman-coded coding scheme, which brings a fine-grain adjustment in access capacity and enhances the overall data throughput when the user signal power varies drastically due to distance, weather, or other challenges in the channel condition. As far as we know, this is the first demonstration of multiple visible light laser source access based on a single integrated GaN/InGaN receiver module.

Self-swelling derived frameworks with rigidity and flexibility enabling high-reversible silicon anodes

Silicon is recognized as the most advantageous next-generation anode material for LIBs in terms of its extremely high theoretical capacity and appropriate operating voltage.However,the application of Si anode is limited by huge volume expansion emerging with cycling,which in turn induces the collapse of the electrode structure,resulting in rapid capacity decay.Here,we report a strategy using self-swelling artificial laponite to prepare a laponite/MXene/CNT composite framework with both rigidity and flexibility,which can excellently address these challenges of Si anode.The self-swelling artificial laponite participates in the construction of hierarchical and porous structures,providing sufficient buffer space to mitigate the volume expansion of the LixSi alloying reaction.Meanwhile,tough and tightly cross-linked silicate nanosheets can improve the mechanical strength of the framework for strong structural stability.More importantly,the negative charge between the layers of artificial laponite can effectively promote fast Li-ion transport in the electrode.This free-standing silicon anode enables the preparation of high areal capacity electrodes to further enhance the energy density of LIBs and a higher reversible capacity of 2381.8 mAh/g at 0.1 C after 50 cycles with an initial coulombic of 85.6%.This work provides a simple and practical fabrication strategy for developing high-performance Si-based batteries,which can speed up their commercialization.

祝融号火星车在轨高精度视觉定位与地形重建

祝融号火星车在火星表面巡视移动3个月周期内,火星车精准定位与摄站周围精细地形重建是一项非常重要的任务,可为后续的路径规划、机构运动和科学探测提供基础信息.利用摄站点间具有重叠区域的立体地形导航全景相机图像,采用图像区域网平差模型实现火星车的连续相对定位,可有效地降低车轮滑移和惯导系统误差累计对定位精度的影响.同时,根据单个摄站的立体地形导航全景相机序列图像,采用闭合区域网平差模型和立体匹配技术实现数字高程模型(digital elevation model,DEM)和数字正射影像图(digital orthophoto map,DOM)的制作.依据祝融号火星车的地面实验,视觉定位精度优于2%,3 m内的地形重建精度优于5 mm,并有效支持祝融号火星车高精度视觉定位、地形重建、快速全局定位、在轨驶离、路径规划、科学目标点位置测量等在轨任务.

天问一号火星探测器着陆点快速精确定位

为实现天问一号着陆点快速精确定位,规划火星车行驶路径,并将火星车后续数据纳入统一的地理坐标系,本研究利用着陆初期有限数据(天问一号环绕器获取的遥感影像、一幅悬停避障缓速下降阶段的GNC(guidance,navigation and control)避障敏感器拍摄的降落影像和导航相机在着陆平台的环拍立体像对)完成定位任务.首先,通过导航相机的环拍影像生成着陆点周围陨石坑、沙丘、火山口、山梁之间的拓扑关系.然后,以根据环绕器的遥感影像生成的数字正射影像图(digital orthophoto map,DOM)为底图,将导航相机生成的陨石坑、沙丘、火山口、山梁之间的拓扑关系与底图预着陆区的陨石坑、沙丘、火山口、山梁之间的拓扑关系进行模糊匹配,以确定疑似着陆点,并结合降落影像在疑似着陆点中确定着陆点的粗略位置.最后,根据导航相机影像多像空间后方交会解算着陆点的精确位置为109.925°E,25.066°N.

Effects of dietary yeast nucleotides on growth, non-specific immunity intestine growth and intestinal microbiota of juvenile hybrid tilapia Oreochromis niloticus ♀ × Oreochromis aureus ♂

This study investigated the effect of dietary supplementation of yeast nucleotides on the growth, nonspecific immunity, intestine growth and intestinal microbiota of juvenile hybrid tilapia. Tilapia(initial average weight of 8.02 g) was fed test diets supplemented with a yeast-originated nucleotide mixture(0,0.15, 0.30, 0.60, and 1.20 g/100 g diet) for 8 weeks. Fish fed the diet with 0.60% nucleotide had significantly higher weight gain than the control group(P < 0.05). Feed efficiency was improved in the fish fed 0.60 and 1.20% nucleotide compared with that in the control group. The optimal doses of nucleotides supplementation for growth and feed efficiency of fish were determined as 0.63 and 0.81%, respectively.Intestinal growth was improved in the 0.30 and 0.60% groups, as indicated by significant increase in intestine length. The fish fed 0.60 and 1.20% nucleotide showed higher super oxide dismutase(SOD)activity and lower malondialdehyde(MDA) level in the liver than the control fish, indicating enhancement of the anti-oxidant status. Serum lysozyme activity was significantly increased in the 0.15 and 0.3%nucleotide supplementation groups, suggesting an enhancement effect on the non-specific immune response. Lastly, dietary nucleotides supplementation exerted moderate influence on the intestinal microbiota of hybrid tilapia. A reduction in the cumulative abundance of putative butyrate-producing species was observed in the intestinal microbiota of fish fed diets with 0.60% nucleotide compared with the control, implying an interaction between dietary nucleotides and butyrate production. Briefly, dietary supplementation with 0.60% nucleotide improve the growth performance, immune activity and intestine growth in tilapia.

Efficient InGaN-based yellow-light-emitting diodes

Realization of efficient yellow-light-emitting diodes(LEDs) has always been a challenge in solid-state lighting.Great effort has been made, but only slight advancements have occurred in the past few decades. After comprehensive work on InGaN-based yellow LEDs on Si substrate, we successfully made a breakthrough and pushed the wall-plug efficiency of 565-nm-yellow LEDs to 24.3% at 20 A∕cm^2 and 33.7% at 3 A∕cm^2. The success of yellow LEDs can be credited to the improved material quality and reduced compressive strain of InGaN quantum wells by a prestrained layer and substrate, as well as enhanced hole injection by a 3 D pn junction with V-pits.

Efficient emission of InGaN-based light-emitting diodes:toward orange and red

Indium gallium nitride(InGaN)-based light-emitting diodes(LEDs)are considered a promising candidate for red-green-blue(RGB)micro displays.Currently,the blue and green LEDs are efficient,while the red ones are inefficient for such applications.This paper reports our work of creating efficient InGaN-based orange and red LEDs on silicon(111)substrates at low current density.Based on the structure of InGaN yellow LEDs,by simply reducing the growth temperature of all the yellow quantum wells(QWs),we obtained 599 nm orange LEDs with peak wall-plug efficiency(WPE)of 18.1%at 2 A/cm^2.An optimized QW structure was proposed that changed two of the nine yellow QWs to orange ones.Compared with the sample containing nine orange QWs,the sample with two orange QWs and seven yellow QWs showed similar emission spectra but a much higher peak WPE up to 24.0%at 0.8 A/cm^2 with a wavelength of 608 nm.The improvement of peak WPE can be attributed to the improved QW quality and the reduced active recombination volume.Subsequently,a series of efficient InGaN-based orange and red LEDs was demonstrated.With further development,the InGaN-based red LEDs are believed to be attainable and can be used in micro LED displays.

Si-substrate vertical-structure InGaN/GaN micro-LED-based photodetector for beyond 10 Gbps visible light communication

Visible light communication(VLC)has emerged as a promising communication method in 6G.However,the development of receiving devices is much slower than that of transmitting devices,limited by materials,structures,and fabrication.In this paper,we propose and fabricate an InGaN/GaN multiple-quantum-well-based vertical-structure micro-LED-based photodetector(μPD)on a Si substrate.A comprehensive comparison of the photoelectrical performance and communication performance of three sizes ofμPDs,10,50,and 100μm,is presented.The peak responsivity of all threeμPDs is achieved at 400 nm,while the passband full-widths at half maxima are 87,72,and 78 nm for 10,50,and 100μmμPDs,respectively.The−20 dB cutoff bandwidth is up to 822 MHz for 50μmμPD.A data rate of 10.14 Gbps is experimentally demonstrated by bit and power loading discrete multitone modulation and the proposed digital pre-equalizer algorithm over 1 m free space utilizing the self-designed 4×450μmμPD array as a receiver and a 450 nm laser diode as a transmitter.This is the first time a more than 10 Gbps VLC system has been achieved utilizing a GaN-based micro-PD,to the best of our knowledge.The investigation fully demonstrates the superiority of Si substrates and vertical structures in InGaN/GaNμPDs and shows its great potential for high-speed VLC links beyond 10 Gbps.

Ordered mesoporous NiFe_2O_4 with ultrathin framework for low-ppb toluene sensing

Highly sensitive and selective detection against specific target gases,especially at low-ppb(part per billion)level,remain a great number of challenges in gas sensor applications.In this paper,we first present an ordered mesoporous NiFe_2O_4 for highly sensitive and selective detection against low-ppb toluene.A series of mesoporous NiFe_2O_4 materials were synthesized by templating from mesoporous silica KIT-6 and its framework thickness was reduced from 8.5 to 5 nm by varying the pore size of KIT-6 from 9.4 to 5.6 nm,accompanied with the increase of the specific surface area from 134 to 216 m^2g^(-1).The ordered mesoporous NiFe_2O_4 with both ultrathin framework of 5 nm and large specific surface area of up to 216 m^2g^(-1)exhibits a highest response(R_(gas)/R_(air)-1=77.3)toward 1,000 ppb toluene at 230℃ and is nearly 7.3 and 76.7 times higher than those for the NiFe_2O_4 replica with thick framework and its bulk counterpart respectively,which also possesses a quite low limit of detection(<2 ppb),and good selectivity.

Photoluminescence properties of Tm^(3+)/Tb^(3+)/Sm^(3+) tri-doped Na_(5)Y_(9)F_(32) single crystal with high thermal stability for white light-emitting diodes

A novel Tm^(3+)/Tb^(3+)/Sm^(3+)tri-doped Na_(5)Y_(9)F_(32)single crystal was synthesized by a modified Bridgman method for the propose of white light emitting diodes.The fluorescence spectra of various Sm^(3+)ion concentrations and fixed 0.4 mol%Tm^(3+)and 0.5 mol%Tb^(3+)were measured and studied systematically excited by near-ultraviolet light of 355 nm.The Sm3+ion concentration takes apparent effect on the relative intensity of peaks in the visible region and the color coordinate combining from these emission bands.A near pure white light emission with color coordinates(0.3295,0.3057)and color temperature(5657 K)can be obtained when the concentrations of Tm^(3+),Tb^(3+)and Sm^(3+)ions are 0.4 mol%,0.5 mol%and 0.8 mol%,respectively.Furthermore,the practical down-conversion internal quantum yield was measured by integrating spheres at about 14.39%.The tri-doped Na_(5)Y_(9)F_(32)single crystal shows a high thermal stability inferring from the temperature dependent emission in which the integrated emission intensities are reduced only by^3%with the increase of temperature from 280 to 450 K.The present results demonstrate that the Tm^(3+)/Tb^(3+)/Sm^(3+)tri-doped Na_(5)Y_(9)F_(32)single crystal may provide a promising candidate for white light-emitting diodes,luminescent materials and fluorescent display devices.

Si-substrate LEDs with multiple superlattice interlayers for beyond 24 Gbps visible light communication

High-speed visible light communication(VLC)using light-emitting diodes(LEDs)is a potential complementary technology for beyond-5 G wireless communication networks.The speed of VLC systems significantly depends on the quality of LEDs,and thus various novel LEDs with enhanced VLC performance increasingly emerge.Among them,In Ga N/Ga N-based LEDs on a Si-substrate are a promising LED transmitter that has enabled VLC data rates beyond 10 Gbps.The optimization on the period number of superlattice interlayer(SL),which is a stressrelief epitaxial layer in a Si-substrate LED,has been demonstrated to be an effective method to improve Si-substrate LED’s luminescence properties.However,this method to improve LED’s VLC properties is barely investigated.Hence,we for the first time experimentally studied the impact of SL period number on VLC performance.Accordingly,we designed and fabricated an integrated 4×4 multichromatic Si-substrate wavelength-divisionmultiplexing LED array chip with optimal SL period number.This chip allows up to 24.25 Gbps/1.2 m VLC transmission using eight wavelengths,which is the highest VLC data rate for an In Ga N/Ga N LED-based VLC system to the best of our knowledge.Additionally,a record-breaking data rate of 2.02 Gbps over a 20-m VLC link is achieved using a blue Si-substrate LED with the optimal SL period number.These results validate the effectiveness of Si-substrate LEDs for both high-speed and long-distance VLC and pave the way for Si-substrate LED design specially for high-speed VLC applications.

Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride by liquid chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry

Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride for doping control purpose were developed.Liquid–liquid extraction was adopted for the sample preparation.Analytes were detected by positive electrospray ionization in single quadrupole and triple quadrupole mass spectrometer.In the screening method,selected ion monitoring(SIM)mode was used to monitor m/z 403 for carboxy-finasteride.In the confirmation method,product ion mode was used to monitor the precursor ion m/z 403.The limit of detection was below 2 ng/mL for the screening method.Good linearity was obtained in the range 10.0–500.0 ng/mL.The intra-run and inter-run precision calculated from quality control(QC)samples was less than 5.3%.The accuracy as determined from QC samples was within ±6.6%.The screening method was applied for the analysis of excretion samples,allowing the detection of carboxy-finasteride for up to 49 h in urine specimen collected after an oral administration of 5 mg of finasteride.